Gastro Cram Flashcards
Pathogenesis of eosinophilic oesophagitis?
Infiltration of epithelium with eosinophils
T-helper type 2 cytokine mediated
Investigation findings of eosinophilic oesophagitis?
Eosinophilia, high IgE
Endoscopy: longitudinal furrows with white plaques and loss of vascular patterns
Diagnosis of eosinophilic oesophagitis?
> 15 eosinophils on biopsy
Persistence of eosinophilia after PPI trial
Management of eosinophilic oesophagitis?
Elimination diet of allergens - milk & wheat common
PPI
Topical steroid - fluticasone/budesonide
Anti IL-5 agents (mepolizumab)
Complications of eosinophilic oesophagitis?
Stricture
Perforation
Food bolus - needs endoscopic removal
Pathogenesis of GORD?
Transient relaxation of LES -> oesophagitis
Disease = reflux + epithelial change, FTT/asp pneumonia
Peak of physiologic reflux?
4 months, usually settles by 12-18mths
GORD with torticollis / dystonic writhing movements and food refusal?
Sandifer Syndrome
Management of GORD?
Positioning Proper feed technique, volume and frequency Thickened feed Hypoallergenic diet PPI -> reduces acidity and discomfort
SEs of PPIs?
Respiratory infections
C Diff, Candida
Low magnesium and low B12
Interstital nephritis
Indications for fundoplication?
Not responsive to medical therapy Peptic strictures or Barrett's Gastrostomy feeds Respiratory disease Neurological disease
Difference between ulcerative colitis and Crohn’s?
Crohn’s - panenteric; UC - colonic
Crohn’s - skip lesions; UC - confluent
Crohn’s - transmural inflammation; UC - Mucosal
Crohn’s - Granulomas; UC - none
Most common mutation causing Crohn’s?
NOD2
Extra-intestinal manifestations of Crohn’s?
Episcleritis (topical steroids)
Uveitis (systemic steroids)
Acute anterior uveitis (urgent topical/systemic steroids) and secondary glaucoma
Erythema nodosum
Pyoderma gangrenosum (less than UC)
Anal fissures 6 and 12 o’clock
Arthritis (<5 joints HLA-B27; >5 HLA-B44)
Abdo pain, diarrhoea and weight loss?
Crohn’s
Abdo pain, diarrhoea and PR bleeding?
UC
Induction of remission in Crohn’s
- Exclusive enteral nutrition (better for mucosal healing)
- Steroids
- Infliximab
Maintenance therapy in Crohn’s?
Mesalazine/sulfasalazine
Azathioprine (6MP prodrug)
Methotrexate
Infliximab/Adalimumab
Azathioprine SEs?
Hypersensitivity - rash, fever Hepatitis Reduced cell counts - TMPT genotype & monitor Pancreatitis HSV and HPV Hepatosplenic T-cell lymphoma Sun sensitivity
Anti-TNF alpha SEs?
Infliximab (chimeric) /Adalimumab (human)
Hepatosplenic T-cell lymphoma (with AZA)
TB reactivation
Demyelination syndrome
Lupus like syndrome
Indications for surgical management of Crohn’s?
Failure of medical management Recurrent obstruction Perforation FIstula/abscess If terminal ileum ONLY & poor growth Carcinoma
When to start bowel ca screening in IBD?
10 years after colonic disease diagnosed
Extra-intestinal manifestations in UC?
More common than Crohn's Pyoderma gangrenosum Sclerosing cholangitis Hepatitis Ankylosing spondylitis
Child with UC presents with fever, profuse stooling (>5/day), low Hb, low albumin, and high WCC?
Fulminant colitis
DO NOT SCOPE - risk of toxic megacolon and perforation
Induction of remission in UC?
- Steroids
- Cyclosporin
- Infliximab
Maintenance therapy in UC?
Mesalazine/sulfasalazine
Azathioprine/6MP
Probiotics helpful
Indication for surgery in UC?
Haemorrhage
Perforation
Cancer
Refractory acute disease
Methotrexate SEs?
Nausea - 25%, reduce with folate Liver toxicity Bone marrow suppression Infections Pulmonary fibrosis
Pathogenesis of coeliac disease?
T-cell mediated inflammatory disorder
Altered intestinal permeability
Gliadin stimulates IL-15 which activates T-cells with HLA-DQ2,8
Biopsy findings in coeliac?
High intra-epithelial lymphocytes
Villous atrophy
Crypt hyperplasia
Loss of brush border
Disorders associated with coeliac?
T1DM Autoimmune thyroid disease Addison Sjogren Autoimmune cholangitis/hepatitis Primary billiary cirrhosis
if TTg greater than normal but less than 10x normal range?
Proceed to scope
If TTg is >10x normal and positive EMA no scope required
Role of HLA-DQ2,8 typing?
Screening of family members
Excluding coeliac if on a GF diet
Stratification for biopsy need