Epilepsy Exam Cram Flashcards
What kind of seizure?
3Hz spike wave
Absence
What kind of seizure?
Centrotemporal sharp waves
Benign epilepsy with centrotemporal spikes / Benign Rolanic Epilepsy
What kind of seizure?
Frequent right occipital spikes
Occipital epilepsy of childhood (Gastaut type)
What kind of seizure?
High amplitude sharp and slow complexes mostly occipital?
Benign Occipital Epilepsy (Panayiotopoulos type)
What kind of seizure?
Hypsarrhythmia
Infantile spasm
What kind of seizure?
Burst suppression
Normal in preterm infant
Late pre-term baby, apgars 9,9 with focal seizure with apnoea day 5 of life. No further seizures since. Normal neuro exam. Normal labs, CSF & neuroimaging. What kind of epilepsy?
Benign neonatal seizures
Neonate with multifocal clonic or tonic seziures in first week of life. FHx of neonatal seizures. What kind of epilepsy?
Benign familial neonatal seizures
Mutation causing benign familial neonatal seizures?
KCNQ2 and KCNQ3
Encephalopathic ex-term baby with erratic myoclonus. EEG shows burst suppression mostly during sleep. What epilepsy?
Early myoclonic epilepsy
2-3mo baby with dev delay, soasticity and focal motor seizures. MRIB shows structural brain abnormality. What epilepsy?
Early infantile epileptic encephalopathy
50% death, 50% severe neurological impairment
Ex prem baby.Normal neuro exam. Milestones not delayed for corrected age. EEG shows burst suppression. What epilepsy?
Normal baby.
Burst suppression normal variant in pre-term babies.
6mo with epileptic spasms usually after waking and developmental regression. EEG shows hypsarrhythmia. What kind of epilepsy?
Infantile spasms / West Syndrome
Most common cause of infantile spasms?
Focal cortical dysplasia
Other aetiologies:
TS / neurocutaneous disorders
T21 / chromosomal disorders
Inborn errors of metabolism
Peri/post-natal insults
Investigations of choice for infantile spasms?
EEG
MRIB
Metabolic workup
Treatment of choice for infantile spasms?
ACTH
Corticosteroids
Vigabatrin (first line in TS)
<18mth infant presenting with febrile status epilepticus, parents reporting developmental regression/plateau?
Dravet Syndrome
Mutation in Dravet Syndrome?
SCN1A
Treatment of choice for Dravet syndrome?
Drugs to avoid?
Valproate
Adjunctive clobazam
AVOID sodium channel blockers in carbamazepine
Afebrile seizures in infancy, ceasing by age 2 with no developmental concerns?
Benign familial epilepsy if FHX
Benign focal epilepsy
8 year old presenting w generalised tonic-clonic seizure during sleep, also has seizures involving the face/tongue/upper limb. EEG demonstrates centrotemporal spikes activated by sleep. What epilepsy?
Benign epilepsy with centrotemporal spikes / Rolandic epilepsy
Management of Rolandic / BECTS ?
No need for AEDs if seizures non-compromising
First line valproate