gastric ulcers

Question 1

how do gastric ulcers arise

Answer 1

• long term use of NSAIDS or corticosteroids

- can come from gastritis

Question 2

how do they work

Answer 2

what usually happens:

• either muscarinic or histamine (H2) receptors are activated
• this activates proton pumps, increasing acid secretion into the stomach lumen = gastric ulcers

what the drug does
- the activation then of PGE2 receptors inhibits the proton pump, decreasing acid secretion = no stomach lumen = no ulcers

Question 3

medicines used in practice

Answer 3

OMEPRAZOLE

• proton pump inhibitors which are absorbed in small intestine
• IV usually

RANITIDINE
- histamine (H2) antagonists

SUCRALFATE

• histamine (H2) antagonists
• forms as a paste and binds to ulcerated areas

MISOPROSTOL
- PGE1 analogue

ANTACIDS
- used in horses