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GI > Gastric Secretion > Flashcards

Gastric Secretion Flashcards

1
Q

Main fx of fundus?

A

Storage

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2
Q

Main fx of body?

A

Storage

Mucus, HCl, Pepsinogen, Intrinsic factor

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3
Q

Main fx of Antrum

A

Mixing,

Gastrin

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4
Q

What do mucous neck cells prod?

A

Mucous

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5
Q

What do chief cells prod?

A

Pepsinogen

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6
Q

What do parietal cells prod?

A

HCL and intrinsic factor

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7
Q

What is the emzyme in parietal cells that catalyses the reaction of h2o and co2 to form h2co3?

A

Carbonic Anhydrase

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8
Q

how is HCL increased in secretion?

4 ways

A

Acetylcholine (m3 muscuranic) Gastrin -> inc Ca rise in cell -> stims protein kinases -> increases K/H

HIstamine (G stimulatroy)
Stims G protein -> a cyclase converts ATP to cAMP
-> protein kinase

Prostaglands (G-inhibitory)

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9
Q

What is an ECL cell?

A

Enterochromaffin-like cell

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10
Q

What is the cephalic phase of gastric acid secretion?

A

Stim before swallowing

Vagus nerve and Gastric/ACh

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11
Q

What is the Gastric phase?

A

Phase in which stomach is relaxed.
Stomach distends stims vagus
Peptides in lumen stim G cells to secrete gastrin
gastrin stims ECL to release histamine

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12
Q

What inhibits gastrin?

A

Gastric Phase - Dec pH

Intestinal Phase -
Acid in DD -> splachnic reflex -> Decr gastrin secr an stim of parietal cells
Fat in DD -> GIP release

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13
Q

What hormones are released from DD mucosa?

A

secretin, CCK, GIP

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14
Q

What causes the release of DD hormones?

A

to acid, hypertonic solutions, fatty acids or monoglycerides in duodenum

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15
Q

What are the main 2 fx of DD hormones?

A

Decr Gastric emptying

Decr Gastric Acid Secretion

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16
Q

What is pepsingoen?

A

a zymogen - innactive enzyme

17
Q

What happens to pepsinogen when the pH decreases?

A

The ogen part is dropped off allowing free pepsin to do it’s fx

18
Q

What is the role of gastric mucous?

A 
Prod bt epi cells and mucus neck cells 
Pepsin = denatured at ph7
Cytoprotective role
Prevents pepsin degredation and acid burn
allows for hco3 to have neutal secretion
19
Q

Where is B12complex absorped?

A

ileum

GI (11 decks)

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