Gastric motility and Pancreatic function Flashcards
Where does most contraction happen in stomach, why and how
Where does most contraction happen in stomach, why and how
what produces gastric peristaltic waves
peristaltic rhythm
slow waves
what is peristaltic rhythm generated by
pacemaker cells in longitudinal muscle layer, only 3/min
what are slow waves
spontaneous depolarisation/repolarisation, slow wave rhythm is basic electrical rhythm, 3/min
depolarisation sub-threshhold - require further depolarisation to induce AP → contraction
what are slow waves conducted through
what are slow waves conducted through
What hormone increases contraction
gastrin
WHAT CONTROLS GASTRIC EMPTYING
CHOLECYSTIKININ
what does distention of stomach cause in relation with contraction
long/short reflexes → inc contraction
what inhibits motility
Fat/acid/amino acid/hypertonicity in duodenum
what neutralises acid in duodenum
bicarbonate secretion from brunners gland duct cells (submucosal glands)
what controls duodenal bicarb secretion
acid in d triggers long (vagal) and short (ENS) reflexes → HCO3 secretion
secretin from S cells → HCO3 secretion
secretin → HCO3 secretion from panc and liver
what inhibits secretin release as negative feedback control
acid neutralisation in duodenum
function of pancreas
exocrine function - helps in digestion
endocrine function that regulates blood sugar
what is the purpose of the exocrine pancreas and what does it do
digestive function
secrete bicarbonate by duct cells
secrete digestive enzymes by acinar cells
what are zymogens and their purpose
digestive enzymes stored as inactive granules, prevent autodigestion of pancreas
