Gastric carcinoma Flashcards
1
Q
How does it spread + what is prognosis + what type
A
Locally, blood, transcoelomic (ovaries)
- prognosis poor
- Adenocarcinoma at GOJ
2
Q
Who does it affect
A
M>F (2:1)
3
Q
What are the RFs
A
Pernicious anaemia H.pylori Atrophic gastritis Adenomatous polyps Lower social class Smoking Diet (high nitrate, high salt, low vit C) E.cadherin abnormalities
4
Q
What are the symptoms
A
- Dyspepsia
- Weight loss
- Vomiting
- Dysphagia
- Anaemia
5
Q
What are the signs
A
- Epigastric mass
- Hepatomegaly
- Jaundice
- Ascites
- Large L supraclavicular node (Virchow’s)
- Acanthosis nigrans
6
Q
What investigations
A
- Gastroscopy
- Ulcer edge biopsies
7
Q
What treatments
A
Surgery, chemo
- Use cisplatin drug
