Gastric Cancer (2) Flashcards
1
Q
What are its 2 types?
What’s its most important risk factor?
→ What are the other risk factors?
A
➊ • Intestinal adenocarcinoma
‣ Common on lesser curvature of stomach
• Diffuse adenocarcinoma
‣ Associated with Signet cells
➋ Chronic H. pylori infection
→ • EBV infection
• Diet - Mainly food with nitrates or salt-based preservatives (Fresh fruit and vegetable are protective here)
• Smoking, Alcohol
• Autoimmune gastritis
• Inherited syndromes (rare)
2
Q
How does it present?
A
• IDA
• Hx of new-onset Dyspepsia
• Early satiety (anorexia)
• Weight loss
• Progressive dysphagia
3
Q
How is it investigated?
How is it managed?
A
➊ • Endoscopy with biopsy
• Staging CT
➋ Surgery, chemo/radiotherapy, targeted therapy
