gastric acid and pancreatitis lab

Question 0

two most common causes of pancreatitis

Answer 0

alcohol

gall stones

Question 1

acute pancreatitis is characterized by..

Answer 1

the destruction of the pancreas due to the autodigestion of pancreatic tissue by inappropriately activated pancreatic enzymes

Question 2

what is the mnemonic for the causes of pancreatis

Answer 2

I GET SMASHED
idiopathic, gallstones, ethanol, trauma, steroids, mumps, autoimmune, scorpion bite, hypercalcemia/hyperlipidaemia, post-ERCP, drugs

Question 3

what are the components of the gastric juice

Answer 3

salt, water, HCL, pepsin, IF, mucous

Question 4

explain the steps for the production of HCl

Answer 4

1. water in and CO2 in –> H2CO3 –> H+ + HCO3-
2. H+ and K+ cotransported across the luminal membrane (H+ out and K+ in)
3. K+ transported back out into the lumen
4. HCO3 and Cl- cotransported at interstitial membrane (HCO3 into interstitium –> blood and Cl into cell)
5. Cl transported into lumen

Question 5

what is the mechanism of histamine stimulating HCl secretion

Answer 5

binds to H2 R on basement membrane –> AC converts ATP to cAMP. –> PKA stimulates the release of HCl

Question 6

what is the mechanism for ACh stimulating HCl release

Answer 6

binds to M3 R on basal membrane of parietal cell –> initiates Ca influx –> Ca binds to CAM –> stimulates HCl secretion

Question 7

what is the effect of caffeine on HCl production and how does this work

Answer 7

increases HCl secretion as it blocks phosphodiesterase breaking down cAMP to AMP so therefore more cAMP to activate PKA for HCl secretion