Gas Transport

Question 1

Oxygen Capacity. Give the equation

Answer 1

The amount of Oz the body could carry if HB was completely saturated.

CA = [HB] g(Oz) / dL(blood) x 1.34 mL(Oz) / g(HB)
= 20. 1 mL(Oz) / dL(blood)

Question 2

What is the total grams of Hb per dL of blood?
How many mL of Oz are in 1 gram of HB?
What is the normal Oxygen Capacity?

Answer 2

15 g(Oz) / dL(blood)
1.34 mL(Oz) / g(HB)
= 20. 1 mL(Oz) / dL(blood)

Question 3

Oxygen Content. Give the equation

Answer 3

The actual amount of Oz in body.

Content = Saturation Hb (%) x Capacity + (solubility * partial pressure of Oz) = mL(Oz) / dL(blood)

Question 4

1 Torr = ______ mmHg

Answer 4

1

Question 5

Polycythemia
Normal
Anemia

These conditions can alter Oz Capacity!! Does not have effect on HB affinity

Answer 5

More RBC, more HB = 20 g(Oz) / dL(blood)
Same RBC, more HB = 15 g(Oz) / dL(blood)
Less RBC, more HB = 10 g(Oz) / dL(blood)

Question 6

What shifts the hemoglobin dissociation curve to the right?

Left?

Answer 6

Increases: cause Oz release

• temp
• COz
• DPG - RBC metabolite
• [H] –> decreased pH - H+ bind to HB reducing Oz affinity

Left: CO

Question 7

carried %’s of COz in blood?

Answer 7

5-10% - Dissolved COz
90% - Bicarbonate (HCO3)
5-10% Carbamino (proteins)

Question 8

Name the enzyme that turns COz into carbonic acid which then rapidly becomes bicarbonate? What is the byproduct of the reaction? What does it do?

Answer 8

carbonic anhydrase

H+ (reduces pH, and binds to HB reducing affinity for Oz)

Question 9

The farther a tissue from a capillary, the less Oz its going to get. If the Capillary partial pressure of Oz is reduced, what are the outcomes? what are they?

Answer 9

Hypoxia - Less that normal Oz reaching tissue
Anoxia - Tissues receives no Oz

*Carbonic anhydrase is ONLY in RBC

Question 10

(4) types of Hypoxia

fio2 - given air

Answer 10

Hypoxic: Different Causes (fio2 will)
Anemia: not enough HB (fio2 won’t help)
Hypo-perfusion - heart not pumping fast enough
Histoxic - Cells can use Oz for metabolism

Question 11

Why is the [Cl-] in venous blood less that arterial blood?

Answer 11

Bicarbonate builds up in RBC, diffuses into blood. Cl- enters cell to help cell maintain neutrality. (occurs in blood with high [COz]. Bicarbonate is higher then in venous blood.

Chloride Shift