GABAergic

Question 1

Type of GABA transporter (GAT)

Answer 1

bidirectional
works againt gaba concentration graidnet
Na+ dependent

GAT1: presynaptic GABAergic terminal
GAT2: extrasynaptic regions
GAT3: on astrocytes process
inhibiting GAT= anticonvulsion

Question 2

GABA Synthesis

Answer 2

Glutamate -> GABA
By glutamate decarboxylase
and PLP

Question 3

GABA transaminase

Answer 3

mitochondrial enzyme
PLP
alphaketo+GABA -> glutamate + succinyl semialdehyde
succinylsemialdehyde -> succinate
enzyme= succinyl semialdehyde dehydrogenase needs water and NAD+ as cofactor

irreversible binding of gamma-viny GABA antiepileptic