ATPase dependent K+ channel

Question 1

ATP ase dependent K+ channel

Answer 1

1. octamer
2. from 4 four forming K+ channel: KIR3,2
3. SUR1 times 4: sulfonylurea receptor subunit
4. SUR1 contain 3 TMD and 2 NBD

ER retention signals to make sure correct assembly of the octamer

Question 2

regulation

Answer 2

1. inward rectification and flow out of ion blocked by Mg2+ and polyamines
2. ATP inactivates it by superfusion
3. ADP activates it by superfusion (even when ATP is present) diazoxide
4. Sulfonylurea inhibits the channel

Question 3

Subunits affected

Answer 3

Kir6.2 -> ATP

SUR1 -> sulfonyurea, ADP and K+ channel openers