GABA pt 2

Question 1

the analgesic effects of intrathecal diazepam in mouse models of inflammatory and neuropathic pain are primarily mediated by what GABAa receptors

Answer 1

alpha2/3GABAa receptors

Question 2

where are alpha2 GABAaRs densely expressed in mouse

Answer 2

lamina II/III dorsal horn neurons
and in primary dorsal root ganglion neurons

Question 3

intrathecal diazepam suppresses the sensitised response to _________evident in both models of both inflammatory (zygomen) and neuropathic (sciatic nerve chronic constriction) pain

Answer 3

heat and mechanical stimulation

Question 4

NAMS of what subtype that bind to the BZ site between the alpha5 gamma2 subunit interface exhibit pro-cognitive properties in mouse models with
huntingtons, alzheimers down syndrome

Answer 4

alpha5beta2

Question 5

NAMs of the alphha5beta2 subtype that bind to the BZ site between the alpha5gamma2 subunit interface exhibit pro-cognitive abilities in mouse models of what mice with what conditions

Answer 5

huntingtons, alzheimers, down syndrome

Question 6

diazepam and flunitrazepam impair cognition when combined with what

Answer 6

alocohol

Question 7

alpha5 GABAaRs are expressed extrasynaptically where

Answer 7

hippocampal CA1 neurons

Question 8

alpha5 GABAaRs are expressed extrasynaptically in hippocampal CA1 neurons where they mediate what kind of current

Answer 8

tonic current

Question 9

the alpha5 knock out exhibits what kind of performance in the water maze spatial learning paradigm

Answer 9

improved

Question 10

why does the alpha5 knockout mouse exhibit a better performance in the water maze spatial learning paradigm

Answer 10

the cognitive effects of diazepam are absent in the alpha 5 knock out mouse

Question 11

NAMS of alpha5 GABAaRs have what effect in mice down syndrome and huntingtons disease

Answer 11

improved cognitive performance and enhances LTP