GABA pt 1 Flashcards
what are the GABAA sub units
alpha 1 and 2
beta 1 and 2
gamma
what do these words describe
anxiolytic, anticonvulsant, analgesic, amnestic, sedative/hypnotic
drugs that enhance the GABAaR
what are types of drugs that enhance the GABAaR function
diazepam
alphaxalone
propofol
babituates
what are benzos used to treat
anxiety and insomnia
induce muscle relaxation
epileptic seizures
how quickly can tolerance develop if using benzos
weeks
what are PAMs known as
positive allosteric modulators
what are used to decrease the function of the GABAaR
NAMs
antagonists
where do benzos bind to on GABAaR
between the alpha and gamma subunit interface
what ion is conducted in the central pore of GABA
cl-
diazepam does not enhace GABA responses mediated by GABAaRs composed of what subunits
alpha1beta1
for high affinity bonding of diazepam the receptor must contain what subunit
gamma2
GABAaRs incorporating the gamma2, and what alpha subunits are diazepam sensitive
alpha1, 2, 3, 5
GABAaRs incorporating the gamma 2 and what alpha subunits are diazepam insensitive
alpha4, 6
alpha, 123and5 have what residue at position 101
H
alpha123and5 have a H residue at position 1010, whereas both alpha4and 6 subunits have what residue at this position
R
autodiaography reveals the alpha 1 mutation to cause a loss of what binding
3H-flumazenil
the sedative effects of diazepam are blunted in what mouse
alpha1H101R
however, the sedative effects are not impaired in what mouse
alpha2H101R
the anxiolytic effects of diazepam are not mediated by what GABAaRs
alpha1betagamma2
the anxiolytic effects of diazepam are mediated by what GABAaRs
alpha2betagamma2
diazepam (increases/decreases) the time spent in a light compartment box for alpha2H101R mouse
increases
diazepam increases time spent om the open arms of the elevated plus maze
these effects (do/do not) occur in the alpha2H101R mouse
these effects (do/do not) occur in the alpha1H101R mouse
these effects do not occur in the alpha2H101R mouse
these effects do occur in the alpha1H101R mouse
