GABA pt 1

Question 1

what are the GABAA sub units

Answer 1

alpha 1 and 2
beta 1 and 2
gamma

Question 2

what do these words describe
anxiolytic, anticonvulsant, analgesic, amnestic, sedative/hypnotic

Answer 2

drugs that enhance the GABAaR

Question 3

what are types of drugs that enhance the GABAaR function

Answer 3

diazepam
alphaxalone
propofol
babituates

Question 4

what are benzos used to treat

Answer 4

anxiety and insomnia
induce muscle relaxation
epileptic seizures

Question 5

how quickly can tolerance develop if using benzos

Answer 5

weeks

Question 6

what are PAMs known as

Answer 6

positive allosteric modulators

Question 7

what are used to decrease the function of the GABAaR

Answer 7

NAMs
antagonists

Question 8

where do benzos bind to on GABAaR

Answer 8

between the alpha and gamma subunit interface

Question 9

what ion is conducted in the central pore of GABA

Answer 9

cl-

Question 10

diazepam does not enhace GABA responses mediated by GABAaRs composed of what subunits

Answer 10

alpha1beta1

Question 11

for high affinity bonding of diazepam the receptor must contain what subunit

Answer 11

gamma2

Question 12

GABAaRs incorporating the gamma2, and what alpha subunits are diazepam sensitive

Answer 12

alpha1, 2, 3, 5

Question 13

GABAaRs incorporating the gamma 2 and what alpha subunits are diazepam insensitive

Answer 13

alpha4, 6

Question 14

alpha, 123and5 have what residue at position 101

Answer 14

H

Question 15

alpha123and5 have a H residue at position 1010, whereas both alpha4and 6 subunits have what residue at this position

Answer 15

R

Question 16

autodiaography reveals the alpha 1 mutation to cause a loss of what binding

Answer 16

3H-flumazenil

Question 17

the sedative effects of diazepam are blunted in what mouse

Answer 17

alpha1H101R

Question 18

however, the sedative effects are not impaired in what mouse

Answer 18

alpha2H101R

Question 19

the anxiolytic effects of diazepam are not mediated by what GABAaRs

Answer 19

alpha1betagamma2

Question 20

the anxiolytic effects of diazepam are mediated by what GABAaRs

Answer 20

alpha2betagamma2

Question 21

diazepam (increases/decreases) the time spent in a light compartment box for alpha2H101R mouse

Answer 21

increases

Question 22

diazepam increases time spent om the open arms of the elevated plus maze
these effects (do/do not) occur in the alpha2H101R mouse
these effects (do/do not) occur in the alpha1H101R mouse

Answer 22

these effects do not occur in the alpha2H101R mouse
these effects do occur in the alpha1H101R mouse