GABA A RECEPTORS

Question 1

What class of drugs primarily targets GABA A receptors?

Answer 1

Benzodiazepines

Question 2

True or False: GABA A receptors are ionotropic receptors.

Answer 2

True

Question 3

Fill in the blank: GABA A receptors are responsible for _____ neurotransmission.

Answer 3

inhibitory

Question 4

Which drug class includes drugs like diazepam and lorazepam?

Answer 4

Benzodiazepines

Question 5

Which class of drugs is known for their muscle relaxant properties and acts on GABA A receptors?

Answer 5

Benzodiazepines

Question 6

What is the mechanism of action of GABA A receptor agonists?

Answer 6

They increase the frequency of chloride channel opening.

Question 7

True or False: Barbiturates enhance GABA A receptor activity.

Answer 7

True

Question 8

What type of drug is phenobarbital?

Answer 8

Barbiturate

Question 9

Fill in the blank: _____ are often used as anesthetics and act on GABA A receptors.

Answer 9

Barbiturates

Question 10

Which class of drugs can cause respiratory depression when combined with GABA A receptor agonists?

Answer 10

Opioids

Question 11

What is a common side effect of benzodiazepines?

Answer 11

Sedation

Question 12

Which drug class includes drugs that are used for treating anxiety and insomnia?

Answer 12

Benzodiazepines

Question 13

True or False: GABA A receptors are only found in the central nervous system.

Answer 13

False

Question 14

What neurotransmitter binds to GABA A receptors?

Answer 14

GABA (gamma-aminobutyric acid)

Question 15

Fill in the blank: _____ can lead to tolerance and dependence when used long-term.

Answer 15

Benzodiazepines

Question 16

Which class of drugs is known for its rapid onset and is often used for sedation?

Answer 16

Barbiturates

Question 17

What is the effect of GABA A receptor antagonists?

Answer 17

They inhibit the action of GABA.

Question 18

True or False: GABA A receptors are involved in the modulation of anxiety.

Answer 18

True

Question 19

What is the primary clinical use of benzodiazepines?

Answer 19

Management of anxiety disorders

Question 20

Fill in the blank: _____ is a GABA A receptor positive allosteric modulator that is often used in epilepsy treatment.

Answer 20

Phenobarbital

Question 21

Which drug class includes drugs like zolpidem and eszopiclone?

Answer 21

Non-benzodiazepine sleep aids

Question 22

True or False: Non-benzodiazepine sleep aids act on GABA A receptors.

Answer 22

True

Question 23

What is the role of GABA A receptors in the brain?

Answer 23

They mediate inhibitory neurotransmission.

Question 24

Fill in the blank: _____ are often prescribed for their anxiolytic and hypnotic effects.

Answer 24

Benzodiazepines

Question 25

What is the significance of the alpha subunit in GABA A receptors?

Answer 25

It determines the pharmacological properties of the receptor.

Question 26

Which drug class can lead to withdrawal symptoms if discontinued abruptly?

Answer 26

Benzodiazepines

Question 27

True or False: Barbiturates have a wider therapeutic index than benzodiazepines.

Answer 27

False

Question 28

What is a potential risk associated with combining alcohol and GABA A receptor agonists?

Answer 28

Increased risk of respiratory depression

Question 29

Fill in the blank: _____ are used in the treatment of seizures and as anesthetics and act on GABA A receptors.

Answer 29

Barbiturates

Question 30

What is the action of GABA A receptor modulators?

Answer 30

They enhance the inhibitory effects of GABA.

Question 31

Which class of drugs is less commonly used now due to their side effects and dependency issues?

Answer 31

Barbiturates

Question 32

True or False: GABA A receptor activation can lead to hyperpolarization of neurons.

Answer 32

True

Question 33

What is the primary function of GABA in the central nervous system?

Answer 33

To inhibit neuronal excitability.

Question 34

Fill in the blank: _____ is an example of a GABA A receptor antagonist.

Answer 34

Flumazenil

Question 35

What is the effect of chronic benzodiazepine use on GABA A receptors?

Answer 35

Downregulation of receptors

Question 36

Which drug class is often used in emergency medicine for sedation?

Answer 36

Benzodiazepines

Question 37

True or False: GABA A receptors are a target for many psychoactive drugs.

Answer 37

True

Question 38

What is the impact of GABA A receptor activation on anxiety levels?

Answer 38

It generally reduces anxiety.

Question 39

Fill in the blank: _____ can enhance the effects of GABA at GABA A receptors.

Answer 39

Benzodiazepines

Question 40

What is a common use of GABA A receptor modulators in psychiatry?

Answer 40

Treatment of panic disorders

Question 41

Which drug class includes medications used for muscle spasms and seizures?

Answer 41

Benzodiazepines

Question 42

True or False: The GABA A receptor is a ligand-gated ion channel.

Answer 42

True