GABA

Question 1

Glutamic acid decarboxylase (GAD) converts ______ to _________.

Answer 1

Converts glutamate to GABA

Question 2

GAT is a ______ that removes GABA from extracellular space.

Answer 2

transporter that removes GABA from extracellular space.

Question 3

Vesicular GABA transporter (VGAT)

Answer 3

loads GABA or glycine into vesicles.

Question 4

________ is an enzyme that inactivates GABA.

Answer 4

GABA aminotransferase (GABA-T)

Question 5

Vigabatrin

Answer 5

Prevens GABA metabolism, which leads to a build up of GABA levels in the brain.

Question 6

Tiagabine

Answer 6

inhibitor of GAT-1, elevates extracellular GABA levels and enhances GABA transmission.

Question 7

Are GABA-A Receptors ionotropic or metabotropic ,and what how to they effect cell?

Answer 7

• Ionotropic.
• Permit Cl ions to enter and move across the cell membrane (hyperpolarizes the cell and causes inhibition of postsynaptic cell).

Question 8

Bicuculline is GABA-A receptor ____________

Answer 8

Competitive GABA-A receptor antagonist.

Has a convulsant effect.

Question 9

Diazepam (Valium) _______ potency of GABA to _____ channel.

Answer 9

A barbiturate which binds to the BDZ receptor & increases potency of GABA to open up channel.

Question 10

Neurosteroids ______ GABA-A.

Answer 10

enhance GABA-A, made from cholesterol

Question 11

Are GABA-B Receptors ionotropic or metabotropic, how to they effect cell and where are they located?

Answer 11

• Metabotropic.
• Inhibits cAMP formation and opens K+ channels.
• Located postsynaptically and presynaptically.

Question 12

GABA-A antagonists promote

Answer 12

arousal, seizures, anxiety.

Question 13

GABA-B agonist drugs are

Answer 13

Muscle relaxant, ex: Baclofen.

May help treatment of addiction.

Question 14

Transcranial magnetic stimulation (TMS)

Answer 14

treatment for people with schizophrenia, especially those who experience persistent auditory hallucinations.