ACh & AAs Flashcards
Acetylcholine (ACh)
acts as a chemical messenger to pass nerve impulses across the neuromuscular junction (between nerve and muscle).
ACh is the chief neurotransmitter in the
PNS
Black Widow Spider Venom _____ ACh release.
stimulates ACh release.
how does curare affect ACh receptors?
blocks ACh receptors causing muscle paralysis.
Botulinum Toxin ______ ACh release.
inhibits ACh release.
Choline-Acetyltransferase (ChAT)
catalyzes the synthesis of ACh.
Vesamicol
a drug that blocks the transport of ACh into the vesicles.
how does AChE inactivate ACh?
breaks down ACh into choline and acetic acid.
AchE Inhibitors can treat what disease?
Used of treatment for Alzheimer’s disease.
- ex: physotigimine
example of irreversible ACHe inhibitor
Insecticides
Nerve gases
vapor cloud or spray which enter the body through skin contact or by inhalation.
Ex: sarin and soman.
ACh Reuptake involves:
Choline + acetate (metabolites) uptake into presynaptic cell.
Cholinergic Receptors
- ) Nicotinic (Ionotropic)
2. ) Muscarinic (Metabotropic)
how do muscarinic drugs agonists affect the PNS?
Can lead to overactivation of PNS (salvation, sweating, pinpoint pupils).
Dry mouth effect
reduced production of saliva that results from muscarinic receptor blockade.
