G1-G3 Flashcards
Microbiological aspects of human and animal
infections and infestations, with emphasis on
their etiologic agents.
Clinical microbiology
is the study of causative agents of infectious diseases of humans and their reactions to such infections.
Medical Microbiology
It is an examination to identify an individual’s specific areas of weakness and strength in order determine a condition, disease or illness.
DIAGNOSTIC PROCEDURES
Antibiosis is a biological interaction between two or more organisms that is detrimental to at least one of them; it can also be an antagonistic association between an organism and the metabolic substances produced by another.
ANTIBIOSIS
In its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of microorganism or organism
Chemotherapy
The study of factors affecting the health and illness of populations.It serves as the foundation and logic of interventions made in the interest of the public health
and preventive medicine.
Epidemiology
A broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms.
Immunology
Implies the presence of microorganisms in or on the body of the host. It is the invasion and growth of germs in the body. The germs may be bacteria, viruses, yeast, fungi, or other microorganisms.
INFECTIONS
A state when the microorganisms is successful in producing physiological or anatomical changes in the host.disease, any harmful deviation from the normal structural or functional state of an organism, generally associated with certain signs and symptoms and differing in nature from physical injury.
DISEASE
Infectious diseases are disorders that are caused by organisms, usually microscopic in size, such as bacteria, viruses, fungi, or parasites that are passed, directly or indirectly, from one person to another.
Infectious disease
Pathogens are taxonomic-ally widely diverse and comprise viruses and bacteria as well as unicellular and multicellular eukaryotes.
Pathogen
The parasite’s ability to cause harm to the host varies with the microbe’s ability to enter or harm host tissues, as well as the state of the host’s defenses.
PATHOGENICITY
a measure of pathogenicity; the degree of pathogenicity
refers to the precise mechanisms used by the pathogen invade and damage host tissues.
Virulence
a toxin secreted by bacteria.
can cause damage to the host by destroying cells or disrupting normal cellular metabolism.A microbial pathogen that causes the most serious and numerous diseases.
Exotoxins
found in Gram negative bacteria
heat stable:less toxic: highly pyrogenic
Endotoxins
A pyrogen is a substance that causes a rise in temperature (fever reaction) in a human or animal through the activation of the innate immune system.
Pyrogenic
The process by which a phagocyte (a type of white blood cell) surrounds and destroys foreign substances (such as bacteria) and removes dead cells.
Phagocytosis
may enable bacteria to resist phagocytosis
Capsule
causes some bacteria to resist phagocytosis
Enzymes
via fomites (objects or materials which likely to carry infection, such as clothes, utensils, and furniture)
Indirect contact
( infection transmitted to humans and other animals by blood-feeding anthropods)
Vectors
non specific resistance
Innate immunity
acquired immunity specific resistance
Adaptive immunity response
the population of microbes routinely found growing on the body surfaces of healthy individuals
Normal flora
cells that engulf and degrade foreign material and cell debris
Phagocytes (Macrophages)
- initiated in response to invading microbes or tissue damage
- the irritant sets into motion a process that limits the extent of the injury
Inflammation
- elevated internal body temperature
- inhibits the growth of many pathogens
- activates and speeds up body defenses
Fever
- antibodies are compounds of proteins and sugar that circulate in the bloodstream. They are created by the immune system to fight germs and foreign substances.
Antibody-mediated immunity
made in the bone marrow and then mature there to become specialized immune system cells.
B cells
- is an immune response that does not involve antibodies but rather involves the activation of macrophages and NK-cells, the production of antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen.
Cell-mediated immunity
can kill any cell harboring such pathogens by recognizing foreign peptides that are transported to the cell surface bound to MHC class I molecules.
T-cells destroy infected cells
They can “remember” which germs were defeated and are then ready to activate the adapted immune system quickly if there is another infection.
Memory T-cells
- preparation of disease-causing agent or its product used to induce active immunity Attenuated vaccine
- a weakened form of the disease-causing microbe or virus that is generally unable to cause disease
Vaccines
- may contain killed microbes or inactivated viruses or
fractions of the microbe - unable to replicate, but retains the immunogenicity of the infectious agent or toxin
Inactivated vaccines
- it can overcome host defenses
- it causes diseases upon entering the body
- slime or capsule-forming bacteria to which the phagocyte cannot attach and thus which destroy phagocytes
Pathogen