G-proteins and receptors

Question 1

Which type of G-protein matches with the receptor M1?

Answer 1

Gq

Question 2

Which type of G-protein matches with the receptor M2?

Answer 2

Gi

Question 3

Which type of G-protein matches with the receptor M3?

Answer 3

Gq

Question 4

Which type of G-protein matches with the receptor Beta-1?

Answer 4

Gs

Question 5

Which type of G-protein matches with the receptor Beta-2?

Answer 5

Gs

Question 6

Which type of G-protein matches with the receptor Alpha-1?

Answer 6

Gq

Question 7

Which type of G-protein matches with the receptor Alpha-2?

Answer 7

Gi

Question 8

Activation of M1 receptor causes:

Answer 8

Stimulation of phospholipase C, causing increased acid secretion in stomach

Question 9

Activation of M2 receptor causes:

Answer 9

Inhibition of adenylyl cyclase, causes potassium channels to open, causing a DECREASED HEART RATE

Question 10

Activation of M3 receptor causes:

Answer 10

Stimulation of phospholipase C, causing contraction of bronchi (VISCERAL smooth muscle)

Question 11

What effect does M3 receptor activation have of VASCULAR smooth muscle?

Answer 11

VASCULAR smooth muscle is indirectly relaxed by M3 receptor activation

Question 12

What effect does M3 receptor activation have of VISCERAL smooth muscle?

Answer 12

VISCERAL smooth muscle contracts when M3 receptors are activated

Question 13

Which type of stimulation (sympathetic or parasymathetci) acts on M1, M2 and M3 receptors?

Answer 13

Parasympathetic

Question 14

Which type of stimulation (sympathetic or parasympathetc) acts on Beta-1, Beta-2, Alpha-1 and Alpha-2 receptors?

Answer 14

Sympathetic

Question 15

The Gs protein activates Beta-1 and Beta-2 to stimulate what?

Answer 15

Adenyl Cyclase

Question 16

Activation of Beta-1 receptor causes:

Answer 16

Increased heart rate and increased force of heart

Question 17

Activation of Beta-2 receptor causes:

Answer 17

Relaxation of bronchial and vascular smooth muscle

Question 18

Activation of Alpha-1 receptor causes:

Answer 18

Stimulation of phospholipase C, Contraction of vascular smooth muscle?

Question 19

Activation of which receptor causes CONTRACTION of vascular smooth muscle?

Answer 19

Alpha-1

Question 20

Activation of which receptor causes RELAXATION of vascular smooth muscle?

Answer 20

Beta-2

Question 21

Activation of which receptor causes INDIRECT RELAXTION of vascular smooth muscle?

Answer 21

M3

Question 22

Activation of which receptor causes CONTRACTION of VISCERAL smooth muscle?

Answer 22

M3

Question 23

Activation of Alpha-2 receptor causes:

Answer 23

Inhibition of adenyl cyclase, causing inhibition of NA release

Question 24

Which G-protein activates which two receptors to cause inhibition of adenyl cyclase?

Answer 24

Gi
M2 (parasympathetic) and Alpha-2 (sympathetic)
(M2 - Decreased HR because opens K+ channels)
(Alpha-2 - Inhibition of NA (noradrenaline) release)

Question 25

Which G-protein activates which three receptors to cause stimulation of phospholipase C?

Answer 25

Gq

M3 (parasympathetic) and Alpha-1 and Alpha 3(sympathetic)