Future of Psychiatry Flashcards by Zohra Rashid | Brainscape

Q

How are antipsychotics used to treat schizophrenia?

A

Effective in treating + symptoms but no affect on chronic symptoms

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Q

What is the pathophysiology of schizophrenia?

A

Abnormality of dopamine neurotransmission underlines psychosis
Dendritic pathology + interneuron involvement
NMDA antagonists = psychotomimetic

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Q

What are the genomics of schizophrenia?

A

Highly polygenic
Many alleles of small effect (SNPs, CNVs)
Risk alleles under negative selection but replenished by new mutations

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