FunMed epithelia and glands Flashcards

1
Q

where do you find simple squamous cells?

A

outer surface of organs and blood vessels

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2
Q

where do you find the mesothelium?

A

lining of the pleua

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3
Q

what sort of epithelium is the mesothelium

A

simple squamous

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4
Q

what is the advantage of the shape of simple squamous cells?

A

ideal for diffusion of gases

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5
Q

what sort of cells line the endothelium?

A

simple squamous

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6
Q

where do you find simple cuboidal epithelia

A

glands and ducts

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7
Q

name 4 ducts lined with simple cuboidal epithelial cells

A

salivary

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8
Q

where is the nucleus normally found in simple cuboidal cells?

A

near the basement membrane

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9
Q

where do you find simple cuboidal cells

A

areas of active absorption of material eg stomach

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10
Q

what do simple columnar cell often have on the apical surface?

A

microvilli

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11
Q

what do microvilli look like in LM pictures

A

brush border

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12
Q

what holds up microvilli?

A

actin filaments

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13
Q

what are pseudostratified cells?

A

squished in but not stratified

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14
Q

where so you find cilia?

A

respiratory tract

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15
Q

what are cillia made of?

A

microtubule and DYNEIN protein

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16
Q

what do cilia do?

A

waft mucus

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17
Q

where would you find non-keratinising stratified squamous cells?

A

places which are abrased but also lubricated eg oesophagus

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18
Q

where do you find keratinised stratified squamous cell

A

skin

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19
Q

what are microtubules made of

A

tubulin protein

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20
Q

what is metaplasia

A

one type of tissue (say stratified cuboidal) is replaced by another (say stratified squamous)

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21
Q

what is neoplasia

A

literally new growth. Often dodgy. Cells grow autonomously without need for growth signals. Can metastasise

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22
Q

what are transitional epithelial cells

A

ONLY FOUND IN THE URINARY SYSTEM<br></br>when bladder is empty

23
Q

where do you find stratified cuboidal cells

A

Big glands - mammary

24
Q

what are the specialised functions of stratified cuboidal cells?

A

layer of cells keeping lumen and underlying tissue separate<br></br>specialised for selective absorptions and secretions<br></br>many junctions keeping the fluid IN THE LUMEN

25
are stereocilia motile
No
26
what are stereocilia made of
actin filaments
27
what is a tight junction
  • nearest to apical surface
  • occluding junction
  • determines which ions & molecules diffuse between cells

28
what is an adhering junction?
below the tight junction
29
what is a Desmosome?
hold adjacent cells togetehr but also have a network of intracellular fibres between desmosomes
30
what is a gap junction
a bit like a plughole. Allows for small molecules and ions to pass directly between cells. 
31
what does a gap junction look like on EM
like the two outer leaflets of adjacent cells have fused
32
what stain can you use to show the basement membrane?
periodic acid schiff
33
what is the basement membrane made of?
collagenous and non-collagenous glycoproteins and proteoglycans
34
how do epithelial cells and basement mambrane interact integrins on basal surface of cells
interacts w proteins in the BM
35
what do glands do
secrete stuff
36
can glands be unicellular
yes
37
what is exocrine secretion
product is secreted onto a surface or into a duct
38
what is endocrine secretion
product is secreted directly into intercellular space
39
what is merocrine secretion
type of exocrine - vesicles fuse with apical cell membrane to secrete the product
40
what is apocrine secretion
top of cell containing vesicles is pinched off to release the product
41
what is holocrine secretion
entire cell dies to secrete the product - eg sebum from sebaceous gland
42
what is an acinar duct
sac like secretory portion then duct
43
where would you find a coiled tubular duct
sweat glands
44
where would you find a branched tubular duct
glands in uterus and stomach
45
what would you see on a LM of squamous cell carcinoma
a lot of keratin in swirls
46
what is adenoma?
benign tumour of epithelial tissue with glandular origin or characteristics
47
what are the characteristics of adenoma?
Cell dysplasia (atypical or loss of normal differentiation of epithelium)
•Irregular cells with hyperchromatic nuclei
•Stratified or pseudo-stratified nuclei
48
what is an adenocarcinoma
cancer that starts in glandular tissue that makes muus or fluids
49
describe characteristics of adenocarcinoma
neoplasia of epithelial tissue that has glandular origin or characteristic
50
where tdo most breast cancers start
ducts and lobules
51
where do colon cancers originate
mucus secreting goblet cells and water absorbing cells
52
40% of lung cancers are....?
adenocarcinomas
53
where do lung adenocarcinomas originate
peripheral lung tissue