Fungus, Animals, Outdoors Flashcards
the most common fungal infection in immunocompromised patients that is a common normal flora that takes advantage of a change in normal flora
candida albicans
a patient presents with cottony feeling in mouth, loss of taste, pain with eating/swallowing, and has white plaques. Dx?
oropharyngeal candidiasis
how to diagnose candidiasis?
KOH prep
the presence of candidiasis where, is an AIDS defining illness?
esophagus
what are 2 treatment options for mucosal candidiasis?
fluconazole
itraconazole
primarily an opportunistic infection in immunocompromised hosts; the most common cause of fungal meningitis, causes pulmonary disease, is found in dried pigeon dung, and is acquired via inhalation.
cryptococcosis
an immunocompromised patient presents with fever, chest pain, dyspnea, cough, hemoptysis. Dx?
cryptococcal pneumonia
an immunocompetent patient presents with headache, fever, lethargy, personality changes, memory loss, nuchal rigidity/meningeal signs, and N/V. Dx?
cryptococcal meningoencephalitis
how does an immunocompromised patient with cryptococcal meningoencephalitis present differently from a immunocompetent patient?
immunocompromised pt may not have meningeal signs
what are 2 diagnostics for cryptococcosis?
CT lungs
lumbar puncture - encapsulated yeast in CSF
what is the treatment for cryptococcosis? (3)
amphotericin B + flucytosine
then fluconazole
linked to bird droppings and bat exposure; causing respiratory illness
histoplasmosis
a patient presents with chills, headache, myalgia, anorexia, cough, and chest pain; after being around birds. Dx?
acute pulmonary histoplasmosis
a patient presents with fever, enlarged liver and spleen, adrenal insufficiency, oropharynx ulcers, fever, dyspnea, cough, weight loss, and chest radiograph shows miliary pattern. Dx?
progressive disseminated histoplasmosis
a patient presents with productive cough, dyspnea, chest pain, fatigue, fever, sweats, and fibrotic apical infiltrates with cavitation on chest radiographs. Dx?
chronic pulmonary histoplasmosis
what diagnostics can be used for histoplasmosis? (4)
CT/Chest xray
biopsy
fungal cultures
urinary antigen
what is the treatment for stable histoplasmosis for under 4 weeks?
no treatment
what is the treatment for mild-moderately severe disseminated histoplasmosis?
itraconazole
what is the treatment for severe histoplasmosis that is causing meningitis and ARDS?
IV amphotericin B
what is the lifelong treatment for AIDS-related histoplasmosis?
Itraconazole
the deadliest parasitic disease in which transmission requires the female anopheles mosquito
malaria
which 2 malaria-causing species have a liver phase?
P. vivax
P. ovale
which malaria-causing species is the worst/most dangerous?
P. falciparum
how is malaria contracted? (5)
bite of infected female Anopheles mosquito
sporozoites go to liver
hepatic schizont ruptures
goes to merozoites
infects RBCs
a patient presents with cold sensation and shivering, then has fever, headaches, vomiting, and then has sweats and tiredness. On physical exam, they have elevated temp, diaphoresis, splenomegaly, mild jaundice, hepatomegaly, and tachypnea. Dx?
uncomplicated malaria
a patient presents with AMS, deep breathing/resp distress, metabolic acidosis, pulmonary edema/ARDs, severe anemia, hypoglycemia, clinical jaundice, and disseminated intravascular coagulation. Dx?
severe malaria (P. falciparum)
why is P. falciparum the most virulent?
targets ANY RBC and leads to end organ damage
what is the gold standard to diagnose malaria?
giemsa-stained blood smear
what other diagnostic can be done for malaria?
dipstick test
what is the treatment for malaria?
chloroquine