Fungi and Helminths Flashcards
Innate Fungi
Neuts for cutaneous and oppurtunistic; alveolar macrophages first line of defense. NK cells. PAMPS are cell wall components activating mannose lectin complement pathway. B-Glucan is T cell rcog by Dectin 1
Adaptive Fungi
enzymes and toxins are Th1 and lead to O2 dependent killing via IFN gamma and DTH leading to resolution
Th2 will exacerbate the infection
Parasites adherence
specific (Duffy Ag spec for Plas Vivax) or non specific (hookworms)
Parasites Innate
Tegument and Cuticle are PAMPs and can be MAC lysed (kills protozoa and dmgs helminths
Neuts and Macros phag ec protozoa
Eos and Mast injure helminths
Parasites Adaptive
Induced by surface antigens or exotoxins leading to ADCC; Eos; CTLS. Intra are Th1 fought, EC leads to Th2 recruitment of Mast cells (IgE) or eos and basos (IgG)
Parasite evasion
Ag variation, masking, Ig/C proteases, Immunosuppresion via release of anti-inflamm factors
Lab diagnostics of Fungi
Microscope = KOH mount to see only yeast
Culture in Sabourauds dextrose agar which kills bacteria with acid and antibiotics
Sporathrix Schenkii
Dimorphic fungi. Mold = rosettes and yeasts = cigar. From rose thorns. Resolved via Th1 response
Mycotic Diseases
- Hypersenstivity - airborne spores, not dep on fungi virulence, leads to allergy
- Mycotoxicosis - Due to production of secondary metabolites which interupt and alter physiology function. ex: ergot, aflatoxin, psychotropy)
- Mycoses - (superficial on skin and hair/nail) (subcutaneous - dermis and under via traumatic transplant) (systemic - orig in lungs to organs usually oppurtunistic)
Protozoans Classificiation
- Amoebas
- Flagellates - trich vaginalis, gardia lamblia inf =ingest spores
- Ciliates - Blanetidium coli
- Apicomplex - all parasitic, most intercell with apical complex at one stage of life
