AutoImmune diseases Flashcards
APECD
Def in AIRE = multisystem AT disease, Tregs also missing, def in neg selection of T cells
IPEX
Def in FoxP3 so no Tregs, multisystem disease
AI Hemolytic Anemia
autoABs against RBC, mediated by C3b opson, MAC lysis. Initiating Ag via molec mimicry, alloAg incompatibility, drug induced changes. Presents as anemia, thrombocytopenia, hepatosplenomegaly. Detect autoABs with direct coombs/ spherocytes in blood. type 2 HSR
Penicious Anemia
auto ab against parietal cells and IF leading to vit B12 def and anemia type 2 HSR
Good Pastures Syndrome
autoabs against type 4 collagen in glom and BM. Phag/C act leading to inflamm and tissue dmg. ImmunoF for IdG deposits type 2 HSR
Pemphigus Vulgaris
desmoglein 1 and 3 (desmosome) leading to oral and dental blisters. mediated by IgG 1 and 4
Myas Gravis
autoabs against alpha nicotinic AchR and NMJ
Graves Disease
autoabs against TSHR leading to hyperthyroidism, goiter, heat, nervous, exopthalmos.
Hashimotos thyroiditis
Hypothyroidism, type 4 hsr, immune cells infiltrate and form ectopic tissue in thyroid
Ins Dep Diab
target = beta cells on panc, Gad45 = Ag, via cross reaction with cox virus leading to Th1 response
Multiple Sclerosis
Myelin Basic protein attack via Th1 response
Inflamm Bowel disease
NOD2 abnorm mucosal T cell reg (Th1 and Th17)
Systemic Lupus
stong assoc with complement Def. Trigger = UV light, deposition of ICs in glom and BVs. Widespread inflamm.
Diag: ANA w/ FITC antiIgG Abs
Rheum Arthritis
CD4 T cells against synovium. Diag: IgM RF (IgM anti IgG). Th1 response
Sjorgens
excocrine glands destroyed (salivary and lacrimal). ANA Abs anti ro and la
