Fungal infections

Question 1

Candidemia

RF
common organism
Things to check

Answer 1

RF - cancer, pancreatitis, indwelling IVC, Abu use, TPN

Check for IE (TTE) and check eyes

Candida albicans (most common)

Question 2

Candidemia treatment

Answer 2

1. Azoles
   - fluconazole
   - amphotericin for fluconazole reisistance
2. Critically unwell or neutropenic
   - Echinocandin - caspofungin, micafungin, antidulafungin
   - Amphotericin B

Question 3

Aspergillus

-typical infection site

Answer 3

alveolar or pulmonary angio –>disseminated innovation

need to culture or PCR from BAL

Question 4

Amphotericin B

• coverage
• A/E

Answer 4

• good for severe systemic infections
• broad coverage, good tissue penetration
• cx significant - nephrotoxicity, hyperaemia, anaemia, infusion reactions etc