Foundations 7 Flashcards
1
Q
What are the 3 major chemotactant signals that attract neutrophils?
A
C5a, LTB4, IL-8
2
Q
What are the important molecules that mediate margination?
A
1) E/P selectins and CD34 on the endothelium
2) Sialyl-Lewis X and L-selectin on leukocytes
3
Q
What are the important molecules that mediate tight-binding of WBCs to vasculature?
A
1) ICAM and VCAM (CD54/106) on vasculature
2) CD-11/18 and LFA1 integrins on leukocytes
4
Q
What molecule is responsible for diapedesis?
A
CD31 (PECAM-1)
