formative 5- endocrinology Flashcards

1
Q

Which of the following is not under the control of the pituitary gland?
A. Thyroid
B. Adrenal cortex
C. Adrenal medulla
D. Testis
E. Ovary

A

C. Adrenal medulla

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2
Q

Which of the following statements is false?
A. The pituitary gland lies in
the sella turcica
B. The weight of the
pituitary gland is around
0.5g
C. ACTH is secreted from the
pituitary during stress
D. The pituitary regulates
calcium metabolism
E. The anterior and posterior
pituitary are distinct on an
MRI scan

A

D. The pituitary regulates
calcium metabolism

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3
Q

In men all the following are mainly produced in the adrenal cortex
except?
A. DHEAS
B. Testosterone
C. Aldosterone
D. 17-OH progesterone
E. Androstenedione

A

B. Testosterone

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4
Q

Which of the following regarding AVP is false?
A. AVP levels have a linear
relationship with serum
osmolality
B. is produced in the pituitary gland
C. stimulates reabsorption of
water in the collecting duct of the nephron
D. in hypotension baroreceptors predominantly activate ADH
production and secretion
E. Further AVP production is no longer effective once urine osmolality has reached a plateau

A

B. is produced in the pituitary gland

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5
Q

Where is growth hormone’s main site of action to stimulate IGF1 release?
A. Bone
B. Liver
C. Adrenal cortex
D. Muscle
E. Pancreas

A

B. Liver

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6
Q

The following are typical features of excess growth hormone secretion
except?
A. Polyuria
B. Joint pains
C. Sweating
D. Hypotension
E. Headaches

A

D. Hypotension

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7
Q

The following hormones all have a circadian rhythm except?
A. Cortisol
B. Testosterone
C. DHEA
D. 17OH progesterone
E. Thyroxine (T4)

A

E. Thyroxine (T4)

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8
Q

Typical features of cortisol deficiency include the following except?
A. Hypotension
B. Muscle aches
C. Weight loss
D. Hyperglycaemia
E. Lethargy

A

D. Hyperglycaemia

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9
Q

A 38 year old lady presented with weight gain,
menorrhagia and constipation. She is most likely to be suffering from?
A. Cushing’s syndrome
B. Addison’s disease
C. Primary
hypothyroidism
D. Graves disease
E. Acromegaly

A

C. Primary
hypothyroidism

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10
Q

Which test would you likely want to perform in a patient with proximal muscle weakness, purple striae and thin skin?
A. Synacthen test
B. Overnight
dexamethasone
suppression test
C. Insulin tolerance
test
D. Glucagon test
E. Skin allergy tests

A

B. Overnight
dexamethasone
suppression test

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11
Q

A 24 year old girl presented with hirsutism,
oligomenorrhoea and acne. What test would you likely carry out from the ones below?
A. Ultra sound adrenals
B. Ultra sound ovaries
C. MRI ovaries
D. CT scan adrenals
E. Prolactin

A

B. Ultra sound ovaries

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12
Q

A 54 year old gentleman presented with
hyponatraemia. All the following conditions need
excluding before confirming SIADH except?
A. Hypothyroidism
B. Hypervolaemia
C. Euvolaemia
D. Adrenal insufficiency
E. Diuretic use

A

C. Euvolaemia

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13
Q

A 66 year old gentleman had a serum sodium of 124 mmol/l, serum osmolality 265 mmol/l and a urine
sodium of 52 mmol/l. What would you like to perform
first?
A. Chest X-ray
B. CT brain
C. Skin turgor and jugular venous pressure test
D. Thyroid function tests
E. Synacthen test

A

C. Skin turgor and jugular venous pressure test

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14
Q

The following are most likely causes of SIADH except?
A. Multiple sclerosis
B. Lung abscess
C. Subdural haemorrhage
D. Lymphoma
E. Cerebrovascular accident

A

A. Multiple sclerosis

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15
Q

A 28 year old presented with a microprolactinoma?
What is the most unlikely symptom?
A. Galactorrhoea
B. Oligomenorrhoea
C. Decreased sexual appetite
D. Headaches
E. Visual field defects

A

E. Visual field defects

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16
Q

The following suppress appetite except:
A. Peptide YY
B. Ghrelin
C. CCK
D. GLP1
E. Glucose

A

B. Ghrelin

17
Q

The main adipose signal to the brain is
A. CCK
B. Neuropeptide y
C. Leptin
D. Agouti-related peptide
E. Adiponectin

A

C. Leptin

18
Q

A 65 year old lady is diagnosed with SIADH.
Her sodium is 123mmol/l. What is your first line of management?
A. If she is symptomatic I will
treat with fluid restriction
B. If she is asymptomatic I
will treat with hypertonic
saline
C. If she is asymptomatic I
will treat with fluid restriction
D. If she is asymptomatic I
will repeat the sodium
level the next day
E. If she is asymptomatic I
will give normal saline

A

C. If she is asymptomatic I
will treat with fluid restriction

19
Q

A patient with Addison’s disease presents with a chest infection. What do you do?
A. Omit his steroids to
avoid immunosuppression
B. Stop his steroids as they
have precipitated a chest infection
C. Double his steroid dose whilst unwell
D. Keep him on his usual
steroid dose
E. Not of the above

A

C. Double his steroid dose whilst unwell

20
Q

The following tests are typical of secondary hypogonadism
A. Low LH; High testosterone
B. Low LH; Low testosterone
C. High prolactin; high
testosterone
D. Low FSH; Low prolactin
E. None of the above

A

B. Low LH; Low testosterone

21
Q

Typical features of hypogonadism in a male include the following except:
A. Decreased sweating
B. Joint and muscular aches
C. Decreased sexual appetite
D. Decreased hair growth
E. Asymptomatic

A

A. Decreased sweating

22
Q

A patient has a noon testosterone level below the normal range. What will you
do?
A. Treat with testosterone gel
B. Repeat the test at 0900h and check for symptoms
C. Repeat the test at noon to keep things equal
D. Refer to endocrinology
E. Ignore it

A

B. Repeat the test at 0900h and check for symptoms

23
Q

The first line treatment for a patient with a symptomatic prolactinoma is usually:
A. Radiotherapy
B. Transphenoidal surgery
C. Dopamine agonists
D. Transfrontal surgery
E. Somatostatin
analogues

A

C. Dopamine agonists

24
Q

Typical visual field defect of a patient with a large pituitary mass is
A. Unilateral quadrantanopia
B. Bitemporal hemianopia
C. Complete unilateral visual field loss
D. Complete bilateral visual field loss
E. None of the above

A

B. Bitemporal hemianopia

25
Q

Satiety is
A. The physiological feeling of no hunger
B. Inhibited by activation of POMC neurons
C. The physiological feeling of hunger
D. Induced by ghrelin release
E. Enhanced by Agouti-related peptide

A

A. The physiological feeling of no hunger

26
Q

The centres of appetite regulation in the brain are mainly found in the:
A. Pituitary
B. Cerebellum
C. Hypothalamus
D. Basal ganglia
E. Brain cortex

A

C. Hypothalamus