Follicular Phase Practice Quiz

Question 1

A single layer of cumulus cells that immediately surrounds the oocyte is called _______

Answer 1

Corona radiata

Question 2

Which of the following is not correctly matched?
A) Primordial follicle - a single layer of squamous cells surround the oocyte
B) Primary follicle - a multiple layer of cuboidal cells surrounds the oocyte
C) Secondary follicle - generation of Zone pellucida
D) Graafian follicle - mature follicle with mature oocyte

Answer 2

B

Question 3

______ in cattle is characterized by the sudden growth of 8-41 small follicles after which one follicle is then selected to continue growth (dominant follicle) while the remainder become atretic and regress.
A) Follicular wave
B) Follicular depletion
C) Follicular atresia
D) Follicular reserve

Answer 3

A

Question 4

In FSH-dependent early antral follicle, the theca interna and granulosa cells coordinate together to synthesize estradiol because ______ and _______.
A) Supply of LDL-cholesterol only to the granulosa cells
B) Expression of LH receptor is confined to the granulosa cells
C) Expression of FSH receptor is confined to the granulosa cells
D) Conversion of progestins to androgens occur only in the granulosa cells
E) Conversion from androgens to estrogens occur only in the granulosa cells
F) Aromatase activity is absent in the granulosa cells

Answer 4

C and E

Question 5

All of the following statements about ovarian steroid biosynthesis are correct except ________ and _______.
A) The transport of cholesterol from the outer to the inner mitochondrial membrane is mediated by cholesterol side-chain cleavage enzyme
B) Steroidogenic acute regulatory protein (StAR) converts cholesterol to pregnenolone, the precursor of steroid hormones
C) Pregnenolone is converted to progesterone by 3beta-hydroxysteroid dehydrogenase
D) Progesterone is converted to testosterone which is then converted to estrogen
E) Aromatase converts testosterone to estrogen
F) Both the progesterone and estrogen are synthesize in the smooth ER

Answer 5

A and B

Question 6

All of the following are false about FSH except _______ and ________.
A) FSh signals via activation of nuclear FSHRs on granulosa cells to stimulate adenylyl cyclase activity and increase production of cAMP
B) FSH plays a critical role in primordial follicle activation
C) FSH is indispensable for follicle growth and antral formation during the preantral to antral transition
D) FSH receptor expression is the lowest in granulosa cells of small antral follicles
E) FSH stimulates the synthesis of progesterone
F) FSH receptors are not expressed in theca interna cells

Question 7

True or false: LHR expression is significantly induced in granulosa cells during follicle selection

Question 8

True or false: Zona pellucida separates thecal and granulosa cell layers

Question 9

True or false: Aromatase is the rate-limiting enzyme in estrogen synthesis

Question 10

Match the term to the definition
A) Folliculogenesis
B) Follicular dynamics
C) Follicular recruitment
D) Follicular selection
E) Follicular dominance
1) Process of follicular recruitment, selection, and dominance
2) Status of the follicle destined to ovulate
3) Reduction of recruited follicular cohort to ovulatory quota
4) Activation of follicles from the resting pool
5) Development of a follicle from primordial to ovulatory stage