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THE PUBLIC > Folate metabolism > Flashcards

Folate metabolism Flashcards

1
Q

Antibacterial agents that target folate metabolism

A

Sulphonamides
Trimethoprim
Pyrimethamine
Methotrexate

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2
Q

Folate metabolism bacterial pathway

A

Dihydropteroate synthetase catalyses dihydropteroate + - Para-aminobenzoic acid to dihydropteroic acid
Production of glutamate and ATP
Formation of dihydrofolate
Dihydrofolate catalysed by dihydrofolate reductase to tetrahydrofolate
Tetrahydrofolate to 5, 10-methylenetetrahydrofolate= nucleic acid synthesis= thymidine, purine and methionine production

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3
Q

Sulphonamide MOA + use

A

Inhibit dihydropteroate synthase

UC, malaria, UTI

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4
Q

Trimethoprim MOA + use

A

inhibition of dihydrofolate reductase

UTI, chronic bronchitis, gonorrhea, typhoid fever

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5
Q

Methotrexate MOA + use

A

Inhibits DHFR

tumour/cancer

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6
Q

Pyrimethamine MOA + use

A

Inhibits DHFR

antimalarial

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THE PUBLIC (10 decks)

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