Antiviral

Question 1

Sites of antiretroviral activity

Answer 1

Viral reverse transcriptase inhibitor= NRTI, NNRTI
Entry/Fusion inhibitors= Maraviroc, Enfuvirtide
Integrase inhibitors= Raltegravir, Elvitegravir, Dolutegravir
Protease enzyme inhibitors= Lopinavir, Darunavir, Atazanavir, Tipranavir, Fosamprenavir

Question 2

Antiviral more toxic than antibacterial

Answer 2

• Viruses use their host cells normal cellular functions to support their own growth so there is limited/difficult selective toxicity
• Very few drugs that are selective enough to prevent viral replication without injury to the infected host cell