Fluoxetine COPY Flashcards
Another name for Fluoxetine
Prozac
What type of class of Drug is Fluoxetine
SSRI
How is the build of Fluoxetine
SERT - Prevents reuptake of Serotonin
NET - Prevents reuptake of Norepinephrine
5HT2c Antagonism - Enhances release of DA and NE
What NTs are increased by Fluoxetine
Serotonin, NE, DA
Why is Fluoxetine a beneficial medication
It has a long half life so it does not need to be titrated down. “Think of Flu”
It is very awakening which help with negative symptoms of depression.
How long does Fluoxetine stay within the blood stream
1 - 2 weeks
What risk must you consider, prior to prescribing fluoxetine
It’s long half life can lead to serotonin syndrome if you add another SSRI,SNRI, MAOIs.
Therapeutic dosages of Fluoxetine
20 - 80 mg
What to initially dose with Fluoxetine
20 mg, then assess in a few weeks
Other indicators of Fluoxetine
OCD
Bulimia
Panic Disorder
Treatment resistant depression ( + olanzapine)
Bipolar Depression
PMDD
When to expect some sort of response
2 - 4 weeks
When should we look to dosage increase
6 - 8 weeks
Side Effects
Sexual dysfunction
GI: ( Decreased hunger), Nausea,
Diarrhea,
Anticholinergic: Constipation and dry mouth.
Insomnia
Sweating
Agitation or restlessness (Especially early in dosing)
When should patient take?
Typically in the AM
Therapeutic range for Bulimia
60 - 80 mg
