Fluoxetine

Question 1

Another name for Fluoxetine

Answer 1

Prozac

Question 2

Why is Fluoxetine a beneficial medication

Answer 2

It has a long half-life, so it does not need to be titrated down. “Think of Flu”

It is very awakening which help with negative symptoms of depression.

“If you miss a dose, take two the next day.”

Question 3

How long does Fluoxetine stay within the blood stream

Answer 3

1 - 2 WEEKS

Question 4

What risk must you consider, prior to prescribing fluoxetine

Answer 4

Its long half-life can lead to serotonin syndrome if you add another SSRI, SNRI, MAOIs.

A lot of interactions - STRONG 2D6 INHIBITOR

Question 5

How long do you have to wait to start an MAOI when d/c fluoxetine

Answer 5

5 weeks

Question 6

Do you have to wait to add another SSRI when d/c fluoxetine

Answer 6

Typically, no

Question 7

Therapeutic dosages of Fluoxetine for depression

Answer 7

20 - 80

Question 8

Initial dosage of fluoxetine

Answer 8

20

Question 9

Max dosage of fluoxetine

Answer 9

80 mg

Question 10

Initial dosage for bulimia

Answer 10

60 mg

Question 11

Therapeutic dosage for Bulimia

Answer 11

60 - 80 mg

Question 12

How to take Fluoxetine

Answer 12

Daily, preferably in the AMs to prevent insomnia

Question 13

What properties of fluoxetine may cause increase agitation or anxiety

Answer 13

5HT2C antagonism = Increases dopamine and NE