Fluoroquinolones Flashcards
1
Q
Fluoroquinolones Function
A
Display a concentration-dependent killing effect.
Excellent bioavailability for transition from intravenous (IV) to oral form.
2
Q
Fluoroquinolones Distribution
A
Distribute well into most tissues and fluids except CNS.
3
Q
Fluoroquinolones Half life
A
ranges from 4 to 12 hours
4
Q
Fluoroquinolones Elimination
A
Renal
5
Q
Fluoroquinolones Mechanism of Action
A
Strong inhibitors of deoxyribonucleic acid (DNA) gyrase and topoisomerase IV.
Possess activity against aerobic gram-negative organisms.
6
Q
Fluoroquinolones Clinical Uses
A
Effective in treating many infections; safe side effect profile.
7
Q
Fluoroquinolones Side effects
A
Tendon rupture can occur ** tell people to reduce physical activity
