FLUMAZENIL (ROMAZICON)

Question 1

Flumazenil (Romazicon)

Answer 1

Name/Class: FLUMAZENIL (Romazicon)/Benzodiazepine Antagonist

Description: Flumazenil is a benzodiazepine antagonist used to reverse the sedative, recall, and psychomotor effects of diazepam, midazolam, and the other benzodiazepines.

Indications: Respiratory depression secondary to the benzodiazepines.

Contraindications: Hypersensitivity to flumazenil or benzodiazepines; those patients who take medication for status epilepticus or seizures; seizure-prone patients during labor and delivery; tricyclic antidepressant overdose.

Precautions: Hepatic impairment, elderly, pregnancy, nursing mothers, head injury, alcohol and drug dependency and physical dependence on benzodiazepines.

Dosage/Route: 0.2 mg IV over 30 sec/min, up to 1 mg.