Flash fact 3

Question 1

Pt with IL-12 receptor deficiencies suffer from what type of infection?
Explain the pathophysiology behind why this occurs.

Answer 1

Mycobacterium: refer to board prep document for pathway.

IL-y is indicated for treatment

Question 2

What is the most important host factor in preventing re-infection of influenza?

Answer 2

Antibodies against hemaggluttinin

Question 3

Why is B12 deficiency more likely in someone with strict vegan diet than complete gastrectomy?

Answer 3

depletion occurs over a long period of time which probably wouldn’t occur in someone with this surgery becasue they would be given supplements.

Question 4

Insulin independent tissues and transporters

Answer 4

Brain, kidney, intestine, liver, RBC

Glut 1-5 except for 4

Question 5

Insulin mediated glucose transport

Answer 5

Glut 4: Muscle and Adipocytes

Question 6

Blue toe, livedo reticularis and normal peripheral pulses

Answer 6

Signs of emboli

Question 7

Signs of embolism following invasive vascular proceedure (angiography, etc) is suspicious for____. What would you find in a histo section of the kidney?

Answer 7

atheroembolic disease.

partially or completely occluded arterial lumen with needle shaped cholesterol clefts within the atheromatous thrombus.

Question 8

Antiviral medication that doesn’t require intracellular activation by viral or cellular kinass

Answer 8

Foscarnet
Note: Sketchy
Bypassing P labler–> doesn’t need to be phosphorylated by viral enzyme

Question 9

What drug withdraw causes acute depression accompanied by fatigue, vivid dreams, hypersomnia and hyperphagia

Answer 9

Cocaine

Described as lethargic and dysphoric

Question 10

FOOSH injury

Answer 10

Scaphoid FRACTURE

Lunate DISLOCATION

Question 11

Ototoxicity in pt being treated for HF

Answer 11

Loop Diuretics

OHH DAANG

Question 12

pt being treated for atrial fibrillation and CHF presents with with cardiac arrhythmia and nonspecific GI symptoms (nausea, vomiting), neurological, visual symptoms

Answer 12

Digoxin Therapy
Inhibition of na-K-ATPase–> increased intracellular sodium and calcium
Hyperkalemia
Increased Vegal Tone

Question 13

Pt with lymphandenopathy that fluctuates in size?

Answer 13

“Waxing and Waning”

Follicular Lymphoma

Question 14

Earliest manifestation of diabetic nephropathy

Answer 14

increased albuminuria

Question 15

Analysis of partially replicated DNA fragments shows uracil. Which bacterial enzyme mediates this?

Answer 15

This is asking which enzyme involved with DNA synthesis catalyses the formation of RNA strands.

Primase: An RNA Pol, synthesises short RNA primer using

Question 16

12 year old boy with intellectual disability. Cytogenetic studies show a small gap near the tip of the long arm of the X-Chromosome. How would the pt phenotypically present. Descibe the pathophysiology of this dz.

Answer 16

This is describing fragile X syndrome:

Defect in expansion of CCG on the FMR1 gene

Question 17

Young obese woman with daily headaches that get worse when leaning over. What optic findings would be present?

Answer 17

Intracranial hypertension: