Fixed Drug reactions ( eruptions)

Question 1

Occur at same site. When does it erupt from the ingestion of offending drug?

Answer 1

30 mins to 8 hrs. ave 2 hours.

6 to fewer lesions occur often only 1.

Question 2

lesions

Answer 2

begin as a red round/ oval patch that can dev a dusky, intensely inflamed central portion and resemble an iris or target lesion similar to erythema multiforme wc may blister or erode.
1 cm to several.

Question 3

Histo for FDE.

Answer 3

subepidermal vesicle formation
necrosis of keratinocytes
mixed superficual and deep infiltrate kf neutrophils eosinophils and mononuclear cells.

Question 4

Drugs causing FDE

Answer 4

Those taken intermittently

NSAID esp pyrazolone derivatives, paraceramil, naproxen; oxicam; mefenamic acid.
sulfonamide.
TMP SMX.
barbutyrates, tetra; fluco; fluoroqi, phenolph, aceta, cetiri; celecox, dextro, hydroxy, levoceitir, quinine. lamorrig, phenylprop, eythro; metfor( sildenaf, mycophenol, chemo, chinese and jap herbs.

Question 5

Risk of FDE has been linked to what HLA?

Answer 5

HLA B22.

Question 6

In an oral provocation test inFDE, The initial percent of the standard dose is used in the tsst

Answer 6

10% of std dose.