Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

A- 6 Chronic Dermatitis and Drug eruptions > Contact derm > Flashcards

Contact derm Flashcards

1
Q

chemical prod paresthesia of fingertips w cyanosis and gangrene. nails yellow.

A

oxalic acid.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

oxalic acid is best neutralized a what?

A

lime water

milk of magnesia.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

is a protoplasmic poison prod white eschar om skin.

may prod glomeruloneph, arrhythmia

A

Phenol (carbolic acid). neutralized by 65% ethyl or isopropyl alcohol.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

phosphorus burns tx

A

Rinse w water.

ff by app of copper sulfate to prod precipitate.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

wht chemicals expand the airbag?

A

sodium azide and cupric oxide propellant cartridge release nitrogen gas w expands bag exceeding 160kph (96 mph)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Dusts of what prod folliculitis.

A

Lime, Zinc, Arsenic.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Capsaicin dermatitis tx

A

Insoluble in water.

Acetic acid 5% ( white vinegar) or antacids (maalox) relieve the burning.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What us chloroacetophenone

A

Lacrimator for tear gas dermatitis.
delayed appearance 24 -72 hrs after exposure.
irritation, sensitizaruon w erythema and severe vesiculation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Tx for tear gas dermatitis

A

Lavage agfected skin w sodium bicarbonate sol and instillation of boric acid solution in eyes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is yperite (dichlorodiethyl sulfide)

A

used jn chemical warfar. sulfur mustard gas. Erythema vesicles bulla used in chemical warfare.
most freq affected sites are covered by clothing, humidified by sweat, groin axilla genitalia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is chloroacetophenone

A

Mace a mixture of tear gas
causes allergic sensitizaruon.
tx : chnge clothes, washing w oil/ milk. ff by washing w water

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

crude petroleum prod what lesions

A

Itching folliculitis acneiform eruptions.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Solvents cause approx how many percent if occupational dermatitis?

A

10%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

allergic contaxy derm hs what hypersensitivty type?

A

type 4 hypersistivity

Cell mediated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Tx acute general allergic contact derm

A

Syst steroid beginnig w 40-60mg/day of prednisone in a single oral dose. tapering slowly to topical steroid.
Eruption limited- Local app of top steroid cream, lotion, aerosol spray.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

strong patch test reactions induce a hyperirritability also called as what sundrome

A

Excited skin syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

a std patch test is applied for how many hrs?

A

48 hrs. then exposed to 5 to 15 j/m2 of UVA and read for another 48 hrs.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

most frequent site for nail polish dermtitis?

A

Eyelids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Toxicodendron ( Poison ivy) dermatitis appeara after how many hrs after exposure?
what is the 1st symptom?

A

48 hours.

marked pruritus is the 1st symptom.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

black dot sign is seen in where?

A

Poison ivy reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

tx poison ivy

A

eruption severe or extensive- Sys steroid begin 40-60 mg prednisone single oral dose daily tapered off over a 3 week period.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

most common cause or allergic cont derm in florists

A

Peruvian lily

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

seaweed dermatitis is caused by a marine blue green alga caled

A

Lyngbya majuscula Gomont.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

reported to cause hemorrhaguc bullae on the feet of farmers.

A

Randox (2- chloro- N, N- diallyl- acetamide)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

trimming during landscaping induce irritant derm caused by

A

Calcium oxalate crystals.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Best screening agents for drmatitis from clothing.

A

Ethylene urea melamine formaldehyde resin.

Dimethylol dihydroxyethylene urea formaldehyde resin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

shoe dermatitis is most freq caused by the ff rubber accelerators.

A

Mercaptobenzothiazole, carbamates, tetramethylthiuram disulfide

28
Q

preservative used in antihumidity sachets.

A

Dimethyl fumarate.

29
Q

most common causw of allergic contact derm in children and adults

A

nickel

30
Q

in a patch test rxn. Nickel xan be detected by applying wht to the test object?
ahat is the positive xolor rxn

A

Dimethyl- glyoxime solution

cotton swab used to apply the sol will turn orange- pink.

31
Q

dental gold lesions

A

oral lichenoid eruptions

32
Q

what chemical is the most often the cause for shoe allergy and glove allergy.

A

Mercaptobenzothiazole- Shoe allergy.

Thiuram- Glove allergy

33
Q

among transdermal meds which one induces the highest rate of allergic rxn?

A

Clonidine

34
Q

contact urticaria ans anaphylaxis are reported most often w what drug? Than w other antibiotics.

A

bacitracin

35
Q

4 structural classes of corticosteroid.

A 
Class 
A- Hydrocortisone; Tixocortol pivalate grp 
B - Triamcinolone acetonide, 
budesonide grp
C- Betamethasone grp 
D- hydrocortisone 17- butyrate group.

freq cross reactions bet B and D.
Tixocortol pivalate and budesonide - best screening agents.

36
Q

are these immunologic or non immunologic reactions? latex, potatoes, phenylmercuric propionate

A

IgE mediated type.

Immunologic type

37
Q

What are non immunologic type?

A 
Does not need prior sensitization. 
nettle rash ( plants), DMSO; sorbic acid, benzoic acid, cinnamic aldehyde, cobalt chloride, trafuril.
38
Q

vast majority of drug reactions.

A 
Simple exanthem (75-95%) 
Urticaria (5-6%)

females 1.3-1.5 times more. except under age 3 yo the boys are most likely affected w drug reactions.

39
Q

RAST has how many percent false negative results rate in penicillin type 1 allergy.

A

20%

40
Q

useful in eval type 1 immediate hyper rxnz

A

skin testing

41
Q

Exanthem in adverse drug rxn spares the face, if its not spared what is the dx considered?

A

DRESS

42
Q

most common cause of drug rxn?

A

Penicillin

TMP SMX

43
Q

Ampi - amox given during ebv infectuon cases how many percent exanthem in adults and children

A

29-69%- adults

100%- children

44
Q

TMP given to aids pxs causes exanthem in how many percent

A

40%

45
Q

antimalarials % in exanthem

A

25 percent

46
Q

overall incidencd of DRESS.

A

1/1000 and 1/10000

47
Q

characteristix feat of DRESS

A

Rash
long lastings symptom
fever greater 38
Multiorgan inv

CBC : Eosinophilia - > 1500 absolute eosinophilia
lymphocyte activation

Frequent reactivation of HHV6, HHV7; EBV, CMV, (60-80% of cases demonstrate HHV family reactivation)

48
Q

skin eruption in DRESS

A

Morbilliform

others:
facial erythema
edema periorbital sparing
impetigo like crusting on chun

49
Q

allopurinol minocycline w has renal or pulmo involvement.

A

Allo- Renal

Mino- Pulmo.

50
Q

first line tx DRESS

A 
Stop causative agent 
High dose sys steroid (1-2 mg/kg/day) 
Pulse IV steroid
IVIG 
cyclosporine
51
Q

most common anticonvulsant causing dress

A

Carbamazepine

52
Q

after how many weekds after starting medicarion does sulfonamide hypersensitivity syndrome occur

A

3 weeks

53
Q

minocycline hyperses syndrome, pxs has deficiency or what enzyme

A

Glutathione S transferases

54
Q

minocycline hypersens. percent of liver and renal involvement.

A

Liver 75%

Renal 17%

55
Q

dapsone hypersesy. most characteristic lesion and tx

A

Morbilliform eruption that heals w desquamation.

icterus and lymphadenopathy. -80% of pxs.

Tx- corticosteroids. mainstay

56
Q

SCORTEN is scoring for what?

A

TEN/ SJS most common model to predict mortality

57
Q

SCORTEN Scoring w percent mortality.

A

0-1 - 3.2% mortality

>5- 90% mortality

58
Q

histo SJS ten

A

Lymphocytic infiltrate at DEJ
necrosis of keratinoxytes
cellular necrosis

59
Q

TEN has elevated what ligand

A

ELEV FAS ligand

FAS TEN

60
Q

in europe what is yhe most common cause of Sjs ten (drug)

in children?

A

allopurinol.

children- sulfonamides, antibioticsF antieleptics. acetaminophen.

61
Q

what scoring can be used to point out causality in sjs ten

A

ALDEN score

62
Q

what HLA haplotype is present in vast majority of carbamazepine induced SJS/TEN patients?

A

HLA B 1502

63
Q

Mechanism for IVIG In TEN.

A

Blocking binding of FasL To Fas, stopping keratinocyte apoptosis.

64
Q

Ave time of epidermal regrowth who survive sjs ten-

A

3 weeks

65
Q

most common sequelae of sjs ten

A

Ocular scarring

vision loss

A- 6 Chronic Dermatitis and Drug eruptions (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions