FIVE CLASSES OF IMMUNOGLOBULIN

Question 1

Predominant antiglobulin in adults

Answer 1

IgG

Question 2

75% of total serum antibody

Answer 2

IgG

Question 3

Produced mainly during SECONDARY IMMUNE RESPONSE

Answer 3

IgG

Question 4

Only immunoglobulin that CROSSES THE PLACENTA

Answer 4

IgG

Question 5

4 Subclasses of IgG

Answer 5

IgG 1
IgG 2
IgG 3
Can activate complement pathway but they are not the best complement factor

Question 6

Functions of IgG

Answer 6

• binds complement
• opsonization
• neutralizes toxins
• crosses placenta

Question 7

monomer in serum

Answer 7

IgA

Question 8

dimer in secretion

Answer 8

IgA

Question 9

J chain

Answer 9

IgA

Question 10

15-20% total serum antibody

Answer 10

IgA

Question 11

found in secretion such as tears, saliva, sweat, breast milk, respiratory tract, genital, and
intestinal secretion

Answer 11

IgA

Question 12

2 subclasses of IgA

Answer 12

• IgA1
• IgA2

Question 13

Functions of IgA

Answer 13

binds antigens and prevents adherence to mucus membranes

Question 14

largest immunoglobulin (pentamer)

Answer 14

IgM

Question 15

10% of total serum antibody

Answer 15

IgM

Question 16

produced during primary immune response

Answer 16

IgM

Question 17

first antibody that produced against an immunogen

Answer 17

IgM

Question 18

Functions of IgM

Answer 18

• binds complement
• neutralizes toxin
• agglutinates antigen
• the best complement activator specifically the classical pathway

Question 19

a cell membrane surface component of B lymphocytes ⁃ short half-life 2-3 days

Answer 19

IgD

Question 20

monomer
elevated during parasitic infection and allergic reactions

Answer 20

IgE

Question 21

for better adherence to body mucosal surfaces

Answer 21

DIMER

Question 22

for easy flow IgG & IgM - triggers classical pathway

Answer 22

MONOMER

Question 23

Phases of Immune Response

Answer 23

1. Antigen Elimination – Phagocytosis
2. Primary Immune Response – IgM
3. Secondary Immune Response – IgG