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IHO Week 2 > Fitzaekerly- Therapeutic Proteins > Flashcards

Fitzaekerly- Therapeutic Proteins Flashcards

1
Q

Name the 3 hematopoietic agents that are erythroid growth factors:

A
  1. Darbepoetin
  2. Erythropoetin
  3. Methoxy polyethylene glycol epoetin
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2
Q

What is the MOA of erythroid growth factors?

A

EPO–> RBC (kidney) via Jak/Stat

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3
Q

How long is the half life of EGFs?

A

Very short!
You have to dose 3-4x/ week IV
PARBE (every week)
Wreg (bi-weekly)

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4
Q

What are the therapeutic uses of EGFs?

A
  1. Anemia- chronic kidney disease

2. High risk surgery

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5
Q

Who should you NOT give EGFs to?

A

Athletes

MPEG pts given chemotherapy (will increase their risk of death)

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6
Q

What are the side effects of EGFs?

A

Thrombus

Hypertension, increased tumor growth, allergic rxns

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7
Q

What are the three myeloid growth factors?

A

Filgramostin
Pegfilgrastin
Sagramostin

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8
Q

Filgramostin acts on what cells?

A

Neutrophils (G-CSF)

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9
Q

Sagramostin acts on what cells?

A

Myeloid cells (granulocytes, eosinophils, basophils and monocytes) (GM-CSF)

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10
Q

What are the half lives of Peg and Fil like?

A

Longer

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11
Q

What are MGFs used for?

A

Cancer chemotherapy

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12
Q

What are the side effects of Filg and Peg?

A

Mild/mod bone pain; rare: allergic rxns, splenic rupture

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13
Q

What are the side effects of Sagramostin?

A

Mod/severe bone pain, fever, malaise, arthralgia, myalgia; capillary leak synd, edema, allergic rxns

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14
Q

What are the two megakaryocyte growth factors?

A

Interleukin 11

Rominplostim

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15
Q

What is the MOA of Mega GFs?

A

Increased platelet production; thrombocytopenia–> autoantibodies

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16
Q

How long do Mega GFs last?

A

3-4 days

17
Q

What are Mega Gfs used for?

A

Cancer chemotherapy adjunct

Thrombocytopenia (low platelets)

18
Q

What are the side effects of mega Gfs?

A

Fatigue, Ha, dizziness, mild edema–> fluid dyspnea anemia

Serious: afib, hypocalacemia

IHO Week 2 (11 decks)

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