Fitz, Influenza Virus Flashcards
Name the two neuraminidase inhibitors and what influenza virus type(s) do they affect?
- Zanamivir
- Oseltamivir
They affect Influenza A and B
Name the two drugs that block viral M2 ion channels and what influenza virus type(s) do they affect?
Adamantanes:
- Amantadine
- Rimantadine
They affect Influenza A
What drug is used for RSV?
Ribavirin
MOA of neuraminidase inhibitors.
Influenza virus binds to sialic acid and the neuraminidase inhibitor STOPS the viral neuraminidase from cleaving the acid from the host lung epithelium.
What is sialic acid?
Glycoprotein in lung epithelium
Osaltamivir administration route and age.
Route - oral
Kids, 1+yo for Treatment and Prevention
A child who comes in with NAUSEA is taking what neuraminidase inhibitor?
Osaltamivir
Zanamivir administration route and age.
Route - inhaled
Kids, 7+yo for treatment, 5+yo for prevention
Zanamivir is NOT recommended for people with what three conditions?
- asthma
- COPD
- respiratory disease
Administer neuraminidase inhibitor within what time frame of symptoms appearing to achieve reduction in what 4 things?
Reduction of:
- Duration of symptoms decreased 1-2 days
- Anti-pyretic use
- Viral shedding
- Complications
Name the groups with the highest burden of influenza?
- Elderly
- COPD
- Asthma
- CHF
- DM
- Pregnant women
- Young children
MOA of adamantanes (2)
- Block M2 (H+) channel to stop the acidification that enables viral replication inside the endosome.
- Also blocks maturation of InfluenzaHA glycoprotein (results in progeny that are poorly infective)
Amantadine - CNS penetration? Elimination route?
Yes, CNS.
Elimination - renal
Ramantadine - CNS penetration? Elimination route?
No CNS.
Elimination - mixed renal/hepatic.
Begin adamantane administration within how many hours of symptom onset.
Within 48 hours
