firts chapter Flashcards
ways that drug enter the body.
- Oral administration
- Absorbtion through the skin or other membranes
- Inhalation
- Injection
oral administration
Via Mouth Nature of GI tract
Easiest method
• Provides a degree of safety (taste, vomit)
• Slow absorption are through?
Via Mouth
Prevents some absorption • pH value of drug (weakly acidic is better absorbed) • Alcohol neutral—easily absorbed • Substances must be lipid-soluble • Pass to liver (first-pass metabolism) • Drugs given at elevated doses Are?
the nature of GI Tract
ways of injection.
Intravenous injection, Intramuscular, Subcutaneous.
INHALATION
gas or vapor state, Delivery.
ABSORPTION THROUGH THE SKIN OR MEMBRANES.
Intranasal, Through mouth, Suppository, Transdermal patch,
HOW DO DRUGS EXIT THE BODY?
elimination, Metabolic events, Chemical properties
FACTORS DETERMINING THE BEHAVIORAL IMPACT OF DRUGS.
Timing
- Drug Interactions (Drug x Drug)
- Cross-Tolerance and Cross-Dependence
- Individual Differences
the common characteristic of timing.
Latency period
• Increase of effect
• Maximum of effect
• Extended-release doses
process of changing the molecular structure of a drug into a form that
is more easily removed by the body
Biotransformation
Acute effect of one drug diminished when taken with
another
Antagonistic
INDIVIDUAL DIFFERENCES
- Weight
- Gender
- Ethnicity
Tolerance for another drug from taking of one drug
Cross-tolerance
One drug substitute for another
Cross-dependence