First Aid: Substance Related Disorders Flashcards
What is the DSM-IV criteria for substance abuse?
Pattern of substance use leading to impairment or distress for at least 1 year with 1 or more of the following manifestations:
- Failure to fulfill obligations at work, school or home
- Use in dangerous situations (ex. driving a car)
- Recurrent substance-related legal problems
- Continued use despite social or interpersonal problems due to the substance use
What is the DSM-IV criteria for substance dependence?
Dependence is substance use leading to impairment or distress manifested by at least 3 of the following within a 12-month period:
- Tolerance
- Withdrawal
- Using substance more than originally intended
- Persistent desire or unsuccessful efforts to cut down on use
- Significant time spent in getting, using or recovering from substance
- Decreased social, occupational, or recreational activities because of substance use
- Continued use despite subsequent physical or psychological problem
What diagnosis supercedes substance abuse?
substance dependence
What is the lifetime prevalence of substance abuse or dependence in the US?
17%
What is the gender difference in substance use and dependence?
men > women
What are the most commonly used substances?
caffeine
alcohol
nicotine
What mood symptoms are common among those with substance abuse or dependence?
depressive symptoms
The development of a substance-specific syndrome due to the cessation of substance use that has been heavy and prolonged.
withdrawal
The need for increased amounts of the substance to achieve the desired effect or diminished effect if using the same amount of the substance.
tolerance
What does ETOH do in the brain?
- Activates GABA (inhibitory) and serotonin receptors
- Inhibits glutamate receptors
What percentage of Americans are alcoholics?
7-10%
List the first two steps in alcohol metabolism.
Alcohol dehydrogenase converts alcohol to acetaldehyde. Aldehyde dehydrogenase converts acetaldehyde to acetic acid.
True or false: alcohol is the most commonly abused substance in the USA?
true
What should be used to screen for alcohol abuse?
CAGE questionnaire
What is considered a positive CAGE?
two or more “yes” answer
At what BAL do most adults (>50%) show obvious signs of intoxication?
.15 mg%
What is the legal limit for intoxication in most states?
.08 - .10 mg%
At what BAL do you see decreased fine motor control
.02 - .05 mg%
At what BAL do you see impaired judgement and coordination?
.05 - .1 mg%
At what BAL do you see ataxic gait and poor balance?
.1 - .15 mg%
At what BAL do you see lethargy and difficulty sitting upright?
.15 - .25 mg%
At what BAL do you see coma in the NOVICE drinker?
.3 mg%
At what BAL do you see respiratory depression?
.4 mg%
What medical phenomenon can methanol, ethanol and ethylene glycol all cause?
increased anion gap metabolic acidosis
What medications should be given to patients who present with altered mental status?
thiamine
glucose
naloxone
What is the treatment for acute ETOH intoxication?
- Ensure adequate airway, breathing and circulation
- Monitor electrolytes and acid-base status
- Obtain finger-stick glucose level to exclude hypoglycemia
- Thiamine, naloxone and folate
Why do you give thiamine to an intoxicated person?
to prevent or treat Wernicke’s encephalopathy
Why do you give naloxone to an intoxicated person?
to reverse the effects of any opioids that may have been ingested
When would you use gastric lavage or charcoal in the treatment of ETOH overdose?
only if it is mixed ETOH-drug overdose
What is the treatment for alcohol dependence?
- AA
- Disulfiram (Antabuse)
- Psychotherapy and SSRIs
- Naltrexone
What is disulfiram?
- Aversive therapy
- Inhibits aldehyde dehydrogenase
- Causes violent retching when the person drinks
How does naltrexone help with ETOH dependence?
Opioid antagonist but helps to reduce cravings for ETOH
Why does ETOH withdrawal occur?
- Alcoholics have a chronically depressed CNS
- When the ETOH consumption ceases, the depressant effect is terminated and CNS excitation occurs
How long does it take ETOH withdrawal symptoms to occur after sober?
6-24 hours
How long do ETOH withdrawal symptoms last?
2-7 days
List some mild s/s of ETOH withdrawal.
Irritability
tremor
insomnia
List some moderate s/s of ETOH withdrawal.
diaphoresis
fever
disorientation
List some severe s/s of ETOH withdrawal.
Grand mal seizures
Delirium Tremens
What are delirium tremens?
- The most serious form of ETOH withdrawal
- Delirium, visual or tactile hallucinations, gross tremor, autonomic instability, fluctuating levels of psychomotor activity
When do DTs usually start after cessation of drinking?
within 72 hours
What percentage of patients hospitalized for ETOH withdrawal develop DTs?
5%
What is the prognosis for DTs?
15-20% mortality rate if untreated
How do you treat DTs?
adequate doses of benzodiazepines
How do you treat ETOH withdrawal?
- Tapering doses of chlordiazepoxide or lorazepam (benzos)
- Thiamine, folic acid and multivitamin (to treat nutritional deficiencies)
- Magnesium sulfate (for post-withdrawal seizures)
What is the name of the syndrome caused by thiamine (B1) deficiency resulting from the poor diet of alcoholics?
Wernicke-Korsakoff syndrome
What are the symptoms of Wernicke’s encephalopathy?
- Ataxia
- Confusion
- Ocular abnormalities (nystagmus, gaze palsies)
What does untreated Wernicke’s encephalopathy progress into?
Korsakoff’s syndrome (chronic and often irreversible)
What are the symptoms of Korsakoff’s syndrome?
Impaired recent memory
Anterograde amnesia
+/- Confabulation (making up answers when memory has failed)
What is VERY important to know when treated AMS?
Give thiamine BEFORE glucose (thiamine is coenzyme in carb metabolism and without it, W-K syndrome may be precipitated)
What is the MOA of cocaine?
-Blocks dopamine reuptake from the synaptic cleft, causing a stimulant effect on the reward system of the brain
List some s/s of cocaine intoxication.
Mimics “fight or flight” because it is a sympathomimetic:
- Euphoria
- Increased or decreased BP
- Tachy or bradycardia
- Nausea
- DILATED pupils
- Weight loss
- Psychomotor agitation or depression
- Chills
- Sweating
- Arrhythmias
- Seizures
- Resp. Depression
What types of hallucinations may be experienced by those on cocaine?
tactile
What cardiovascular complications are seen in those with cocaine intoxication?
MI or CVA due to vasoconstrictive effect
What is the differential diagnosis for cocaine intoxication?
- Amphetamine intoxication
- PCP intoxication
- Sedative withdrawal
How long with cocaine show up in a urine drug screen?
3 days (longer in heavy users)
How do you treat cocaine intoxication?
- Benzos (mild to moderate agitation)
- Haloperidol (severe agitation or psychosis)
- Symptomatic support
How do you treat cocaine dependence?
- Psychotherapy
- TCAs
- DA agonists (amantadine, bromocriptine)
What happens when you abruptly abstain from cocaine?
dysphoric “crash”
What are symptoms of cocaine withdrawal?
- Malaise
- Fatigue
- Depression
- Hunger
- Constricted pupils
- Vivid dreams
- Psychomotor agitation or retardation
How do you treat cocaine withdrawal?
supportive (sleep off)
List the classic amphetamines.
- Dextroammphetamine (Dexedrine)
- Methylphenidate (Ritalin)
- Methamphetamine (Ice, speed, “crystal meth”, “crack”)
List the substituted (designer) amphetamines.
- MDMA (ectasy)
- MDEA (eve)
What is the MOA of classic amphetamines?
-Release DA from nerve endings, causing a stimulant effect