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USMLE Step 1. > First Aid Classic Presentations > Flashcards

First Aid Classic Presentations Flashcards

1
Q

Abdominal pain, ascites, hepatomegaly

A

Budd-Chiari syndrome (posthepatic venous thrombosis)

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2
Q

Abdominal pain, diarrhea, leukocytosis, recent antibiotic use

A

C. Diff infection

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3
Q

Achilles tendon xanthoma

A

Familial hypercholesterolemia (low LDL receptor signaling)

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4
Q

Adrenal hemorrhage, hypotension, DIC

A

Waterhouse-Friderichsen syndrome (meningococcemia)

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5
Q

Anaphylaxis following blood transfusion

A

IgA deficiency

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6
Q

Anterior “drawer sign” (+)

A

ACL injury

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7
Q

Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints

A

Marfan

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8
Q

Athlete with polycythemia

A

secondary to erytropoietin injection

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9
Q

Back pain, fever, night sweats

A

Pott Disease (vertebral TB)

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10
Q

Bilateral acoustic schwannomas

A

Neurofibromatosis type 2

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11
Q

Bilateral hilar adenopathy, uveitis

A

Sarcoidosis (noncaseating granulomas)

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12
Q

Black eschar on face of patient with diabetic ketoacidosis

A

Mucor or Rhizopus fungal infection

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13
Q

Blue sclera

A

Osteogenesis imperfecta (type 1 collagen defect)

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14
Q

Bluish line on gingiva

A

Burton line (lead poisoning)

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15
Q

Bone pain, bone enlargement, arthritis

A

Paget Disease of bone (high osteoblastic and osteoclastic activity)

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16
Q

Bounding pulses, diastolic heart murmur, head bobbing

A

Aortic regurgitation

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17
Q

“Butterfly” facial rash and Raynaud phenomenon in a young female

A

SLE

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18
Q

Cafe-au-lait spots, Lisch nodules (iris hamartoma), cutaneous neurofibromas, pheochromocytomas, optic gliomas

A

Neurofibromatosis type 1

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19
Q

Cafe-au-lait spots (unilateral), polyostotic fibrous dysplasia, precocious puberty, multiple endocrine abnormalities

A

McCune-Albright syndrome (mosaic G protein signaling mutation)

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20
Q

Calf pseudohypertrophy

A

Muscular dystrophy (most commonly Duchenne, due to X-linked recessive frameshift mutation of dystrophin gene)

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21
Q

Cervical lymphadenopathy, desquamating rash, coronary aneurysms, red conjunctivae and tongue

A

Kawasaki disease (treat with IVIG and aspirin)

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22
Q

“Cherry red spots” on macula

A

Tay-Sachs (ganglioside accumulation) or Niemann-Pick (sphingomyelin accumulation), central retinal artery occlusion

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23
Q

“Cherry red spots” on macula

A

Tay-Sachs (ganglioside accumulation) or Niemann-Pick (sphingomyelin accumulation), central retinal artery occlusion

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24
Q

Chest pain on exertion

A

Angina (stable: with moderate exertion; unstable: with minimal exertion or rest)

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25
Q

Chest pain, pericardial effusion/friction rub, persistent fever following MI

A

Dressler syndrome (autoimmune-mediated post-MI fibrinous pericarditis, 2-12 weeks after acute episode)

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26
Q

Chest pain with ST elevation on EKG

A

Unstable angina (troponin -) or STEMI (troponin +)

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27
Q

Child uses arms to stand up from squat

A

Gowers sign (Duchenne MD)

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28
Q

Child with fever later develops red rash on face that spreads to body

A

“Slapped cheeks” (erythema infectiosum/fifth disease parvovirus B19)

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29
Q

Chorea, dementia, caudate dengeration

A

Huntington Disease (autosomal dominant CAG repeat expansion)

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30
Q

Chrioretinitis, hydrocephalus, intracranial calcifications

A

Congenital toxoplasmosis

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31
Q

Chronic exercise intolerance with myalgia, fatigue, painful cramps, myoglobinuria

A

McArdle disease (skeltal muscle glycogen phosphorylase deficiency)

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32
Q

Cold intolerance

A

Hypothyroidism

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33
Q

Conjugate horizontal gaze palsy, horizontal diplopia

A

Internuclear opthalmoplegia (damage to MLF; may be unilateral or bilateral)

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34
Q

Continuous “machine-like” heart murmur

A

PDA (close with indomethacin; open or maintain with PGE analogs)

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35
Q

Cutaneous/dermal edema due to connective tissue deposition

A

Myxedema (caused by hypothyroidism, Graves disease [pretibial])

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36
Q

Cutaneous flushing, diarrhea, bronchospasm

A

Carcinoid syndrome (right-sided cardiac valvular lesions, High 5-HIAA)

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37
Q

Dark purple skin/mouth nodules in a patient with AIDS

A

Kaposi sarcoma, associated with HHV-8

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38
Q

Dark purple skin/mouth nodules in a patient with AIDS

A

Kaposi sarcoma, associated with HHV-8

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39
Q

Deep, labored breathing/hyperventilation

A

Kussmaul respirations (DKA)

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40
Q

Dermatitis, dementia, diarrhea

A

Pellagra (niacin [B3] deficiency)

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41
Q

Dilated cardiomyopathy, edema, alcoholism or malnutrition

A

Wet beriberi (thiamine [B1] deficiency)

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42
Q

Dog or cat bite resulting in infection

A

Pasteurella multocida (cellulits at inoculation site)

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43
Q

Dry eyes, dry mouth, arthritis

A

Sjorgen syndrome (autoimmune destruction of exocrine glands)

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44
Q

Dysphagia (esophageal webs), glossitis, iron deficiency anemia

A

Plummer-Vinson syndrome (may progress to esophageal squamous cell carcinoma)

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45
Q

Elastic skin, hypermobility of joints, higher bleeding tendency

A

Ehlers-Danlos syndrome (type 5 collagen defect, type III collagen defect seen in vascular subtype)

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46
Q

Enlarged, hard left supraclavicular node

A

Virchow node (abdominal metastasis)

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47
Q

Episodic vertigo, tinnitus, hearing loss

A

Meniere disease

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48
Q

Erythroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells

A

Mycosis fungoides (cutaneous T cell lymphoma) or Sezary syndrome (mycosis fungoides + malignant T cells in blood)

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49
Q

Facial muscle spasm upon tapping

A

Chvostek sign (hypocalcemia)

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50
Q

Fat, female, forty, and fertile

A

Cholelithiasis (gallstones)

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51
Q

Fever, chills, HA, myalgia following antibiotic tx for syphillus

A

Jarisch-Herxheimer reaction (rapid lysis of spirochetes results in endotoxin release)

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52
Q

Fever, cough, conjunctivitis, coryza, diffuse rash

A

Measles

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53
Q

Fever, night sweats, weight loss

A

B symptoms (staging) of lymphoma

54
Q

Fibrous plaques in soft tissue of penis with abnormal curvature

A

Peyronie disease (connective tissue disorder)

55
Q

Golden brown rings around peripheral cornea

A

Kayser-Fleischer rings (copper accumulations from Wilson Disease)

56
Q

Gout, intellectual disability, self-mutilating behavior in a boy

A

Lesch-Nyhan syndrome (HGPRT deficiency, X-linked recessive)

57
Q

Hamartomatous GI polyps, hyperpigmentation of mouth/feet/hands/genitalia

A

Peutz-Jeghers syndrome (inherited, benign polyposis can cause bowel obstruction; higher cancer risk, mainly GI)

58
Q

Hepatosplenomegaly, pancytopenia, osteoporosis, aseptic necrosis of femur, bone crises

A

Gaucher disease (glucocerbrosidase deficiency)

59
Q

Hereditary nephritis, sensorineural hearing loss, cataracts

A

Alport syndrome (mutation in collagen IV)

60
Q

Hyperphagia, hypersexuality, hyperorality, hyperdocility

A

Kluver-Bucy syndrome (bilateral amygdala lesion)

61
Q

Hyperreflexia, hypertonia, Babinski present

A

UMN damage

62
Q

Hyporeflexia, hypotonia, atrophy, fasiculations

A

LMN damage

63
Q

Hypoxemia, polycythemia, Hypercapnia

A

“Blue bloater” (chronic bronchitis; hyperplasia of mucous cells)

64
Q

Indurated, ulcerated genital lesion

A

Nonpain: chancre (primary syphilis, Treponema pallidum)

Painful,with exudate: chancroid (haemophilus ducreyi)

65
Q

Infant with “cherry red” spot on macula, hepatosplenomegaly, and neurodegeneration

A

Niemann-Pick disease (genetic sphingomyelinase deficiency)

66
Q

Infant with cleft lip/palate, microcephaly or holoprosencephaly, polydactyly, cutis aplasia

A

Patau (trisomy 13)

67
Q

Infant with hypoglycemia, hepatomegaly

A

Cori disease (debranching enzyme deficiency) or Von Gierke disease (G6P deficiency, more severe)

68
Q

Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect

A

Edwards (trisomy 18)

69
Q

Jaundice, palpable distended non-tender gallbladder

A

Courvoisier sign (distal obstruction of biliary tree)

70
Q

Large rash with bulls-eye appearance

A

Erythema chronicum migrans from Ixodes tick bite (Lyme disease: Borrelia)

71
Q

Lucid interval after traumatic brain injury

A

Epidural hematoma (Middle meningeal artery rupture)

72
Q

Male child, recurrent infections, no mature B cells

A

Bruton disease (X-linked agammaglobulinemia)

73
Q

Male child, recurrent infections, no mature B cells

A

Bruton disease (X-linked agammaglobulinemia)

74
Q

Mucosal bleeding and prolonged bleeding time

A

Glanzmann thrombasthenia (defect in platelet aggregation due to lack of Gp2b/3a)

75
Q

Muffled heart sounds, distended neck veins, hypotension

A

Beck triad of cardiac tamponade

76
Q

Multiple colon polyps, osteomas/soft tissue tumors, impacted/supernumerary teeth

A

Gardner syndrome (subtype of FAP)

77
Q

Myopathy (infantile hypertrophic cardiomyopathy), exercise intolerance

A

Pompe disease (lysosomal alpha-1,4-glucosidase deficiency)

78
Q

Neonate with arm paralysis following difficult birth

A

Erb-Duchenne palsy (superior trunk [C5-C6] brachial plexus injury: “waiter’s tip”)

79
Q

No lactation postpartum, absent menstruation, cold intolerance

A

Sheehan syndrome (pituitary infarction)

80
Q

Nystagmus, intention tremor, scanning speech, bilateral internuclear ophthalmoplegia

81
Q

Painful blue fingers/toes, hemolytic anemia

A

Cold agglutinin disease (autoimmune hemolytic anemia caused by Mycoplasma pneumoniae, infectious mononucleosis, CLL)

82
Q

Painful fingers/toes changing color from blue to white to red with cold or stress

A

Raynaud phenomenon (vasospasm in extremities)

83
Q

Painful, raised red lesions on pads of fingers/toes

A

Osler nodes (infective endocarditis, immune complex deposition)

84
Q

Painless erythematous lesions on palms and soles

A

Janeway lesions (infective endocarditis, septic emboli/microabscesses)

85
Q

Painless jaundice

A

Cancer of the pancreatic head obstructing bile duct

86
Q

Palpable purpura on buttocks/legs, joint pain, abdominal pain (child), hematuria

A

Henoch-Schonlein purpura (IgA vasculitis affecting skin and kidneys)

87
Q

Pancreatic, pituitary, parathyroid tumors

A

MEN 1 (autosomal dominant)

88
Q

Periorbital and/or peripheral edema, proteinuria, hypoalbuminemia, hypercholesterolemia

A

Nephrotic syndrome

89
Q

Pink complexion, dyspnea, hyperventilation

A

“Pink Puffer” (emphysema: centriacinar [smoking], panacinar [alpha1-antitrypsin deficiency])

90
Q

Polyuria, renal tubular acidosis type II, growth failure, electrolyte imbalances, hypophosphatemic rickets

A

Fanconi syndrome (multiple combined dysfunction of the proximal convoluted tubule)

91
Q

Pruritic, purple, polygonal planar papules and plaques (6 Ps)

A

Lichen planus

92
Q

Ptosis, miosis, anhidrosis

A

Horner syndrome (sympathetic chain lesion)

93
Q

Pupil accommodates but doesn’t react

A

Argyll Robertson pupil (neurosyphilus)

94
Q

Pupil accommodates but doesn’t react

A

Argyll Robertson pupil (neurosyphilus)

95
Q

Rapidly progressive limb weakness that ascends following GI/upper respiratory infection

A

Guillain-Barre syndrome (acute inflammatory demyelinating polyradiculopathy subtype)

96
Q

Rash on palms and soles

A

Coxsackie A, Secondary syphilus, Rocky Mountain Spotted Fever

97
Q

Reccurent cold (noninflamed) abscesses, unusual eczema, high serum IgE

A

Hyper-IgE syndrome (Job syndrome: neutrophil chemotaxis abnormality)

98
Q

Red “currant jelly” sputum in alcoholic or diabetic patients

A

Klebsiella pneumoniae pneumonia

99
Q

Red “currant jelly” stools

A

Acute mesenteric ischemia (adults), intussusception (children)

100
Q

red, itchy, swollen rash of nipple/areola

A

Paget disease of the breast (sign of underlying neoplasm)

101
Q

Red urine in the morning, fragile RBCs

A

Paroxysmal nocturnal hemoglobinuria

102
Q

Renal cell carcinoma (bilateral), hemangioblastomas, angiomatosis, pheochromocytoma

A

von Hippel-Lindau disease (dominant tumor suppressor gene mutation)

103
Q

Resting tremor, rigidity, akinesia, postural instability, shuffling gait

A

Parkinson disease (loss of dopaminergic neurons in substantia nigra pars compacta)

104
Q

Retinal hemorrhages with pale centers

A

Roth spots (bacterial endocarditis)

105
Q

Severe jaundice in neonate

A

Crigler-Najjar syndrome (congenital unconjugated hyperbilirubinemia)

106
Q

Severe RLQ pain with palpation of LLQ

A

Rovsing sign (acute appendicitis)

107
Q

Severe RLQ pain with rebound tenderness

A

McBurney sign (acute appendicitis)

108
Q

Short stature, cafe-au-lait spots, thumb/radial defects, high incidence of tumors/leukemia, aplastic anemia

A

Fanconi anemia (genetic loss of DNA crosslink repair; often progresses to AML)

109
Q

Single palmar crease

A

Down syndrome

110
Q

Situs inversus, chronic sinusitis, bronchiectasis, infertility

A

Kartagener syndrome (dynein arm defect affecting cilia)

111
Q

Skin hyperpigmentation, hypotension, fatigue

A

primary adrenocortical insufficiency (Addison disease) causes high ACTH and high alpha-MSH production

112
Q

Slow, progressive muscle weakness in boys

A

Becker MD (X linked missense mutation in dystrophin; less severe than duchenne MD)

113
Q

Small, irregular red spots on buccal/lingual mucosa with blue-white centers

A

Koplik spots (measles; rubeola virus)

114
Q

Smooth, moist, painless, wart-like white lesions on genitals

A

Condylomata lata (secondary syphilis)

115
Q

Splinter hemorrhages in fingernails

A

Bacterial endocarditis

116
Q

“Strawberry” tongue

A

Scarlet fever, Kawasaki disease

117
Q

Streak ovaries, congenital heart disease, horseshoe kidney, cystic hygroma at birth, short stature, webbed neck, lymphedema

A

Turner Syndrome (45, XO)

118
Q

Sudden swollen/painful big toe joint, tophi

A

Gout/podagra (hyperuricemia)

119
Q

Swollen gums, mucosal bleeding, poor wound healing, petechiae

A

Scurvy (vitamin C deficiency: can’t hydroxylate proline/lysine for collagen synthesis)

120
Q

Systolic ejection murmur (crescendo-decrescendo)

A

Aortic stenosis

121
Q

Telangiectasias, recurrent epistaxis, skin discoloration, arteriovenous malformations, GI bleeding, hematuria

A

Osler-Weber-Rendu sydnrome

122
Q

Thyroid and parathyroid tumors, pheochromocytoma

A

MEN 2A (autosomal dominant RET mutation)

123
Q

Thyroid tumors, pheochromocytoma, ganglioneuromatosis

A

MEN 2B (autosomal dominant RET mutation)

124
Q

Toe extension/fanning upon plantar scrape

A

Babinksy sign (UMN lesion)

125
Q

Unilateral facial drooping involving forehead

A

LMN facial nerve (CN VII) palsy; UMN lesions spare the forehead

126
Q

Urethritis, conjunctivitis, arthritis in a male

A

Reactive arthritis associated with HLA-B27

127
Q

Vascular birthmark (port wine stain) of the face

A

Nevus flammeus (benign, but associated with Sturge-Weber syndrome)

128
Q

Vomiting blood following gastroesophageal lacerations

A

Mallory-Weiss syndrome (alcoholic and bulimic patients)

129
Q

Weight loss, diarrhea, arthritis, fever, adenopathy

A

Whipple disease (Tropheryma whipplei)

130
Q

“worst headache of my life”

A

Subarachnoid hemorrhage

131
Q

“worst headache of my life”

A

Subarachnoid hemorrhage

132
Q

Swollen, hard painful finger joints

A

Osteoarthritis (osteophytes on PIP [Bouchard nodes], DIP [Heberden nodes])

USMLE Step 1. (19 decks)

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