FireCracker 12/9 + Qbank Flashcards
parietal periotneum pain
constant
severe
antibiotics in pancreatitis if
pseudocyst or abscess
acute abdomen etiology
periotnitis
obstruction
peritonitis PE findings
rigidity
Trousseau’s syndrome
migratory superficial thrombophlebitis
associated with pancreatic/visceral cancer
PPSV23 alone
adults <65 with chronic health conditions
viral conjunctivitis treatment
warm/cold compresses
bacterial conjunctivitis treatment
eryhtomycin/antibacterial drops
bacterial conjunctivitis treatment in contact lens users
fluroquinolone
Glucagonoma
necrolytic migratory erythema
DM
GI symptoms
glucagon >500
thiazide diuretic mechanism
inhibit NaCl co transport in DCT
thiazide - decreased levels of
K, Na, H
hypokalemia, hyponatremia, metabolic alkalosis
thiazide - increased levels of
Glucose, Lipids, Uric Acid, Calcium
loop diuretics mechanism
block Na/K/2CL symporter in thick ascendling limb of loop of Henle
loop diuretic toxicities
ototoxicity, hypokalemia, hypocalcemia, hypomagenseimia, dehydration, allergy-sulfa, nephritis (AIN), gout
potassium sparing diuretics mechanism
act on collecting tubule
spironolactone and eplerenone
competitive inhibitors of aldosterone receptors
only work in presence of aldosterone
spironolactone AE
hyperkalemia
gynecomastia
amenorrhea
anti-androgen effects
carbonic anyhdrase inhibitors
acetazolamide
PCT
inhibit production/reabsorption of filerted bicarb
carbonic anhydrase inhibitors use
treatment of ICHTN
acetazolamide toxicities
hyperchloremic metabolic acidosis hypokalemia NH toxicity neuropathy sulfa allergy
mannitol
osmotic diuretic, increases tubular fluid osmolarity –> increase urine flow
mannitol toxicity
pulmonary edema
intravascular dehydration
stable angina treatment
BB, CCB, nitrate
localized complex empyema treatment
surgery
pneumonia in HIV - most commona
pneumococcal or streptococcal
ectoptic ACTH
small cell lung cancer
massive PE symptoms
hypotension and right heart strain
symptoms of right heart strain
jugular venous distension
RBBB on ECG
atb for human bite
amoxicillin-clauvanate
untreated hiatal hernia can lead to
esophageal adenocarcinoma
aspirin toxicity
resp alkalosis followed by increased AG metabolic acidosis
ventricular aneurysm following MI
5d-3months
decomponsenated heart failure
ventricular aneurysm ECG
peristent ST elevation and deep Q waves
when is CT approriate in pyelonephritis
no clinical improvement for 72 hrs
gallbladder biliary carcinoma blood tests
increased CEA and CA 19-9 but not sensitive/specific
gold stage 1
sa bet agnoist
gold stage II
la bronchodilator: anticholergic or laba
gold stage III
inhaled corticosteroids
gold stage IV
o2
hypertrophic cardiomyopathy
- ventricular hypertrophy
- impaired ventricular relaxation
familial hypertrophic cardiomyopathy
pts 20-40
AD mutation in myosin
Freidreich’s ataxia
HCM murmur
sysytolic
diamond shaped, LSB
HCM treatment
asymptomatic - no treatment
surgery, alcohol ablation reduce outflow obstruction
beta blockers, ndh CCB
non-dhydropyridine CCB
diltiazem
verpamil
HCM pts should avoid
strenous exercise
drugs that increase LVOT (diuretics, nitrates, vasodilators)
risk factors for Budd-Chiari
myeloproliferative disease, oral contraceptives, pregnancy, malignancy, hypercoaguable dz
Budd Chiari presentation
HSM
ascites
abdominal pain
renal impairement
budd chiari gold standard for diagnosis
venography
long term complications of budd chiari
liver failure
renal failure
SBP
portal htn
treatment of budd chiari
anticoag with heparin + warfarin venous stenting diuretics TIPS liver transplant
hypOkalemia EKG changes
flattened/inverted T waves
U waves
ST depression
PVC/PAC, arrhythmias
rhonchi
larger airways
crackles/rales
inhalation/airway opening
first line bacterial sinusitis
amoxicillin clauvanate
centor criteria
fever, tonsillar exudates, tender anterior cervical LAD, absence of cough
RADT with 2
strep throat antibiotic
penicillin
microcytic anemia differential
iron def heavy metal toxicity anemia of chronic dz thalesemmia minor sideroblastic anemia
TCA toxicity - mechanism
fast Na channels slowed
TCA toxicity EKG
QRS>100
splenectomy
impaired antibody mediated opsonization in phagocytosis
MGUS diagnosis
<10% plasma cells
MGUS next step
metastatic skeletal bone survery
HF and alcohol abuse in pt
think alcholic dilated cardiomyopathy
heparin binds
ANTI-THROMBIN III
heparin inactivates
THROMBIN
Factors IXa, Xa, XIIa
Fibrin
Fondaparinux
binds antithrombin III but mainly inactivates factor Xa
monitoring of heparin
aPTT
Heparin/LWMH reversal
protamine
Warfarin mechanism
blocks vit-k dependent clotting factors (II, VII, IX, X, Protein C & S)
monitoring of warfarin
INR/PT
warfarin antidote
hold warfarin, let normalize
Vit K
FFP
days to achieve target INR
2-5
bridge with heparin
plasminogen activators
urokinase
streptokinase
alteplase
t-PA
desmopressin
treats hemophilia A & vWD by releasing vWF from storage sites
aspirin mechanism
inhibits both COX 1&2
clopidogrel
adp-receptor blocker
abciximab
gpIIb/IIIa inhibitor
dipyridamole
PDE III inhibitor
cilostazole
PDE III inhibitor
blocking PDE
increases cAMP
reduced platelet aggregation
vasodilation
ADP-receptor blockers, GP iib/iiia inhib/PDE inhibitors used…
after ACS
PCI
what to do when you suspect meningitis
cultures
empiric antibiotics + corticosteroids
lumbar puncture
corticosteroids are effective for what cause of meningitis
streptococcus
airborne isolation
tb, measles, varicella
ampicillin added to empiric menigitis treatment if
> 50 yr old
alcohol abuse
immunocomprimised
headache red flags
over age 50/new onst
hx of malignancy
acute in onset
prophrylaxis in transplant pts
tmp-smx for pcp
digoxin toxicity
nausea, vomiting
non-inflammatory chronic prostatitis
a febrile, normal leukocyte count
irritable voiding symptoms
primary hyperaldosteronism
HTN, metabolic alkalosis
hypokalemia
mild hypernatremia
aldosterone-plasma renin greater than 20
hypersensitivity pneumonitis treatment
avoid exposure
bacillary angiomatosis
HIV pts, Bartonella
treat w/ eryhtomycin
pigment gallstones
calcium bilrubinate
actinic keratosis
sandpaper-like
“cutaneous horns”
WPW treatment
cardioversion
antiarrythmics like procainamide
vitiligo
hypopigmentation
association with autoimmune dzs like pernicious anemia
cool extremities
cardiogenic shock, hypovolemic shock
blood shunted away from extremities
warm extremities
distributive shock - anayphylaxis, sepsis, spinal shock
wide complex tachycardia
qrs >120
indicates dz below AV node –> ventricular tachycarida
rate control in a fib
digoxin, CCB, BB
pressures in mitral stensosis
increased LA pressure
increase LA-LV pressure gradient
fish mouth valve
scarring/narrowing of mitral valve with fusion of commissures in RHD/MS
MS ausculation
low pitched diastolic rumble
opening snap
loud S1
MS ausculation with increasing severity
gap between oepning snap and s2 decreases
MS CXr
dilated left atrium
straightening of left heart border
elevation of mainstem bronchus
MS echo
LAE
possible RV enlargement
other symptoms associated with mitral stenosis
PA HTN –> right sided heart failure
stroke
TE, A fib
mitral stenosis drugs
diuretics
sodium restriction
BB
SIADH
excess ADH
impaired water excretion
excessive water retention
causes of SIADH
ectopic production of ADH CNS disorder/trauma pul dz surgery drugs
ectopic production of ADH
small cell carcinoma
CNS trauma disorder/SIADH
stroke
hemorrhage
infection
psychosis
pulm disease/SIADH
pneumonia
surgery/siadh
transphenoidal pituitary surgery
main lab concepts in SIADH
HYPOnatreium
serum HYPOosmolality
uirne osmolality >100 (dilute)
lab values in SIADH
low sodium, low serum osm, submax dilute urine osm normal urine na excretion reduced AG low BUN low uric acid
SIADH treatment - first line, emergency
3% hypertonic saline
raise 0.5-1meq/hr
SIADH treatment - non emergent
fluid restriction (force kidneys to excrete free water)
vasopression receptor antagonists
loop diuretics
demeclocycline
V2 receptor antagonists
reduce aquaporin channels in renal collecting ducts
decrease permeability to water, reduces amount of wtaer resaborbed
aspirin intox s/sx
hyperventilation
tinnitius
N/V
AMS
arrythmia treatment in TCA overdose
- na bicarb
- lidocaine
- shock
TCA toxicity =
anticholinergic + cardiac
aspirin + respiratory system
hyperventilation + resp alkalosis
aspirin toxicity managed thru
IV hydration, GI decontimation, glucose, alkalization of serum and urine, possible hemidialysis
ECG in opioid toxicity
methadone - OTc prolongation
TCA toxicity treatment approach
cardiac monitoring, treat seizures, arrhythmias, hypotension
TCA toxicity, treat hypotension w/
Nabicarb
crystalloid solutions
Epi/Norepi
TCA cardiotoxicity
Widened QRS, prolonged QT and PR intervals
ventricular tachycardia, AV block
aspirin + metabolism
interferes with kreb cycle, oxidative phosphorylation
organophosphate =
acetylcholinesterase inhibitor
cholinergic agent
organophosphoate - what receptors
nicotinic
muscarinic
organophosphate symptoms
Salivation, Lacrimation, Urinating, Diaphoresis, GI, Emesis
Bradycardia, Bronchospasm, bronchorrhea
signs of organophosphate poisoning related to nicotinic
paralysis, muscle weakness, fasiculations
treatment of organophosphate poisoning
atropine
pralidoxime (regenerate achesterase)
decontamination of skin and clothes
atropine
competitivre muscarinic receptor antagonist
prevent resp arrest
pralidoxime
acetylcholinesterase reactivaing agent
OPIDP
organophosphate induced delayed polyneuropathy
1-5 weeks after
painful stocking glove paresthesias
weakness in LE
anticholinergics MOA
block ach in CNS and PNS
often have anti-muscarinic properties
anticholinergic toxicity treatment
physostigmine
other components of anticholinergic toxicity treatment
sedatives-benzos
cooling mechanisms
bladder emptying
elevated RDW
mixed population of cells
micro + macro
reticulocyte production index
% retic x pts hct divided by normal hct x reticulocyte maturation time
lyme dz treatment
doxycycline
lyme dz treatment in pregnancy
amoxicillin
Babesiosis
ixodes tick, NE US
hemolytic anemia/jaundice
zenker diverticulum
dysphagia, halitosis
~ neck mass
cortisol associated electroylte abnormality
hypokalemia
endopthalmitis
post op
pain, decreased visual acutity
culture vitreous
metabolic alkalosis is due to…
gain in HCO3- or loss of H+
most common cause of alkalosis
Vomiting
loss of H+ in GI fluids
metabolic alkalosis and effects on kidney
usually impaired renal fxn - decreased GFR - chloride depletion = volume contraction - hypokalemia
kidney ability to secrete HCO3- depends on
countertransport of Cl-
metabolic alkalosis overview
ph high low H+ high HCO3- high PCO2 compensate with hypoventilation
s/sx of metabolic alkalosis
similar to hypocalemia
confusion/paresthesias, tetany, muscle cramping
Urine Cl
less than 20: responsive
greater than 20: chloride unresponsive
urine k in metabolic alkalosis
usually low
treatment of chloride responsive metabolic alkalosis
saline (increases filtered cl- and hco3- secretion)
treatment of chloride unresponsive metabolic alkalosis
correct hypokalemia + saline
acetazolamide
ph > 7.7 with hypervolemia
Hcl through central line
babieosis etiology
tick bite
transfusion
perinatally
babiesosis symptoms
fevers/chills/myalgia
–> anemia, jaundice
babesiosis blood smear
maltese cross
intra-rbc ring form
babesiosis treatment
atovaquone + azithromycin
OR
clindamycin + quinine
cut off for kidney stones
greater than 5 cm
increased homocysteine
b12/folic
BNP associated with
ventricular stretch
S3
cyclophosphamide adverse effect
bladder carcinoma
tricupsid insuff, on the differential
carcinoid syndrome
smudge cells
cll
hypocalcemia
hyperactive DTR
blood transufions
before intubation in COPD exacerbation
2 hr trial of NPPV
amikacin, class of drugs
aminoglycoside
acyclovir AE
nephrotoxicity
sebhorrehic dermatitis
yellow greasly looking scales
sebhorreic dermatitis association with
HIV, parkinson dz
superior vena cava sydrome
swelling of head/neck/arms
usually associated with malignancy
porphyria cutanea tarda
painless blisters on dorsum of hands
facial hypertrichosis
hyperpigmentation
recurrent renal stone - diet changes
decrease na, protein
increase citrate
recurrent kidney stone - medication
thiazides
potassium citrate
bicarbonate
increased renin, increased aldosterone
2ndry hyperaldosteronism (renin secreting tumor)
decreased renin, increased aldosterone
primary hyperaldosteronism
primary hyperaldosteronism
sodium retention –> HTN
hypokalemia
metabolic alkalosis
primary hyperaldosteronism causes
adrenal adenoma - conn’s syndrome
bilateral adrenal hyperplasia
adrenal carcinoma
aldosterone-to-renin ratio in primary alderstonism
greater than 30
MEN 1
parathyroid
pancreatic
pituitary
MEN 2A
MTC
pheochromocytoma
parathyroid
MEN 2B
MTC, pheochromocytoma
marfanoid
mucous and intestinal neuromas
sickle cell trait manifestations
hematuria (renal papillary necrosis)
UTI, renal medullary carcinoma
splenic infarcations, VTE, priapism
phemphigus vulgaris
flaccid bullae - painful, rupture
Nikolsky’s sign (epidermal separation/acantholysis)
autoantibodies against desmoglein
tinea corporis
ring shaped, annular patches w/ central clearing
itchy
associated with immunosuppresion
mixed cryoglobulinemia - triad
palpable purpura, proteinuria, hematuria.
bronchiectesis, history will include
recurrent bacterial infections
Secondary HyperParaThyroidism
decrease Ca
increased Phos
increased PTH
rash involving palms and soles think
syphillis
toxic shock syndrome
fever, hypotension, diffuse macular erythroderma
toxic shock syndrome - risk factors
nasal packing
amiodarone - 5 main side effects
pulm tox hepatotox thyroid skin changes corneal deposits
basal cell carcinoma on face
moh’s surgery
febrile neutropenia treatment
anti-pseudomonal agent
no breath sounds after endotracheal intubation, consider…
ETT advanced too far
increased alk phos, always consider
paget’s disease
increase pH and calcium
increased affinity of albumin for calcium –> decrease calcium
Enthesitis
tenderness over heels, tibial tuberosities, iliac crests
associated wtih AS/B27
dissolve gallstones with
UDA
warfarin induced skin necrosis think
protein c def
low magnesium can cause
low calcium
small cell vs squamous cell
small - acth
squamous - pth
giant cell tumor of bone
eccentrically placed lytic area/soap bubbles
epiphyses
neutropenia =
ANC less than 1500
less than 500 - very high risk of infection
therapuetic approaches to hepatic encephalopathy
lactulose
rifaximin, neomycin
diet - protein and energy
branched chain AA, probiotic supplementation
3 common causes of neutropenia
bone marrow failure - drugs/toxins
bone marrow invasion - malignancy/metastatic
isolated neutropenia - granulocytosis
work up for neutropenic fever
CXR - pulmonary infection
pan culture (including LP)
CBC with diff
CMP
pancreatic cancer - all risk factors
smoking
chronic panc, obesity, DM, post family hx
most common location of pancreatic cancer
head of pancreas
Toursseau’s sign
migratory thrombophlebitis (pancreatic cancer)
pancreatic cancer diagnosis
ct abdomen
ca 19-9, cea may be elevated
What is the classic presenting sign for a patient with underlying pancreatic cancer?
painless jaundice
What surgical procedure is indicated in patients with early stage pancreatic cancer?
resection by whipple - pancreaticodudoenectomy
groups at greatest risk for pancreatic cancer
african americans, men
What palliative surgical procedures can be done for patients with pancreatic cancer?
biliary stenting to prevent jaundice and permanent ablation of the celiac nerves to decrease back pain.
What causes the deficiency of uroporphyrinogen decarboxylase seen in porphyria cutanea tarda?
80% acquired
20% autosomal dominant
What is porphyria cutanea tarda?
deficiency of hepatic uroporphyrinogen decarboxylase (UROD) that results in chronic blistering skin and liver manifestations.
What cutaneous manifestations are associated with porphyria cutanea tarda?
Chronic blistering skin lesions on sun exposed areas of the body (face, ears, neck, forearms, back of the hands, etc…) because the porphyrins that accumulate are photosensitizing.
hyperpigment, hypertrichosis
What notable pharmacology correlate is associated with acute exacerbations of porphyrias?
barbituates (p450 inducers)
What are some hepatic manifestations associated with porphyria cutanea tarda?
Mild elevations in liver enzymes (ALT and AST)
Advanced liver disease in older patients with recurrent disease
Increased risk of cirrhosis and hepatocellular carcinoma
What risk factors are associated with porphyria cutanea tarda?
Alcoholism Hepatitis C Iron overload Estrogen use Smoking Hepatic siderosis
What biochemical evidence can be used to support the diagnosis of porphyria cutanea tarda?
Increased total plasma porphyrin
Increased urine porphyrin
Decreased uroporphyrinogen decarboxylase
Elevated AST and ALT
preferred treatment of Porphyria cutanea tardia?
repeated phlebotomy
In addition to repeated phlebotomy, what other treatment options are available for patients with porphyria cutanea tarda?
Low dose chloroquine or hydroxychloroquine (for patients who do not tolerate phlebotomies) Sunscreen use (to mitigate photosensitivity) Avoidance of triggers (alcohol, tobacco, estrogens, iron supplements)
transcellular K shift causing hyperkalemia
insul def
acidosis
tumor lysis syndrome/cell destruction
beta blockers
SLE - photosensitivity
rash
fever, fatigue, joint pain
pseudohyperkalemia
hemolysis
leukocytosis
fist clenching
SLE antibodies
anti-dsDNA
anti-Sm
decreased C3,C4
SLE - renal disorders
Class IV - diffuse prolif GN (nephritic)
Class V - MGN (nephrotic)
what causes the rise in systemic pressure in chronic constrictive pericarditis
reduced right ventricular EDV
SLE treatment
NSAIDs - pain
hydroxychloroquine - skin, renal
corticosteroids
anticoag
discoid rash
red raished patches
keratotic scaling
SLE rare complications
LSE
abortions
anti-ro(SSA) ab crossing placenta
interstitial lung fibrosis
electrolyte abn in hyperaldosteronism
hypokalemia, alkalosis
decreased free ca concentration
primary hyperaldosteronism complications
metabolic aklalosis, hypernatremia
increased GFR w urinary albumin excretion
increased risk of CVD
treatment post unilateral adenalectomy
monitor aldosteron, K
d/c HTN, spirolactone meds
sodium rich diet
SOAP
serositis
oral ulcers
arthritis
photosensitivity
BRAIN
blood disorders renal ANA immunological neurological
SLE - serositis
pleuritis
pericarditis
pneumonitis
osteomyelitis presentation
bone pain
fever, chills, fatigue
osteomyelitis - 3 lab findings
WBCs
ESR
CRP
osteomyelitis - imaging
Xray - lytic lesion surrounded by sclerosis
MRI - soft tissue involvement
osteomyelitis - organims specific to patient populations
sickle cell - salmonella
diabetics/IV drugs - pseudomonas
most common cause of osteomyelitis
s aureus
osteomyelitis complications
amputation
pathologic fractures
osteomyelitis - physical exam
tenderness over bone
erythema
development of osteomyelitis
hematogenous spread
local extension
direct inoculation
osteomyelitis risk factors
immunodef
iv drug use
poor vascular supply
recent trauma/surgery
MVP
myxomatous degeneration of mitral valve leaflets
flattening of diaphragm in COPD due to
increased work of breathing
renal disorder requiring emergency plasmapheresis
good pastures
mediastinal mass differential
thymoma
teratoma
thyroid neoplasm
terrible lymphoma
seminoma
elevated bhcg only
DI treatment
desmopressin
positive prussian blue
hemosidering hemolytic episodes (G6PD def)
G6PD def pathophys
underlying oxidative stress
Bullous pemphigoid
blisters
often caused by meds
itching
Bullous phemphigoid - biopsy
igg and c3 deposits
med for decreased appetite in cancer pt
progesterone analog - megestrol acetate
infiltrating ductal carcinoma prognosis
TNM staging
palpable masses + HTN
ADPCKD
hypopigmented patches - summer, tropical location
tinea versicolor
malassezia globosa
tinea versicolor
pleural fluid glucose less than 60
rheumatoid, tb, lupus
parapneumonia
malignant
amyloid deposits
apple-green birefringence
amyloidosis renal failture
nephrotic
epiglottis common organisms
h flu
streptococcus pyogenes
solitary pulmonary nodule
rounded opacity
less than 3 cm
completely surrounded by pulmonary parenchyma
no associated LAD
hypertrophic osteoarthropathy
digital clubbing
sudden onset arthropathy - usually wrist and hand joints
can be assocciated with lung dz
lumbar spinal stenosis exacerbated by
extension - standing, walking downhill
rx for dermatitis herpetiformis
dapsone
GVHD - cause
activation of donor T lymphocytes
variocele
soft scrotal mass
decreases when supine/increases when standing
doesn’t illuminate
What medications have been linked to bullous pemphigoid?
furosemide
NSAIDS
ACEI
antiobiotics
What is bullous phemphigoid?
autoimmune supepidermal blistering disease
How is bullous pemphigoid diagnosed?
skin biopsy with direct immunofluoresence
igg and C3
bullous phemphigoid - oral lesions?
rare
What do the skin lesions look like on physical exam in bullous pemphigoid?
tense fluid filled blisters on flexor surfaces
negative nikolsky’s sign
Describe the classic presentation in bullous pemphigoid.
prodrom - pruritis, plaque-like lesions for weeks
then fluid filled blistesrs
Complications seen with bullous phemphigoid?
bacterial infection
What is the first-line treatment of bullous pemphigoid?
corticosteroids
What is the treatment of bullous pemphigoid in patients who are refractory to medical therapy?
IVIG
How does G6PD deficiency lead to hemolysis?
oxidative injury to RBC
G6PD classic presentation
sudden anemia
dark urine
jaundice
What are the 2 common findings on peripheral smear in a patient with G6PD deficiency?
heinz bodies
bite cells
What are the two man precipitants of hemolytic episodes in patients with G6PD deficiency?
infections
medications
What is the inheritance pattern of G6PD deficiency? In whom is it most commonly seen?
X linked recessive
men
What drugs can precipitate a hemolytic episode in patients with G6PD deficiency (remember the mnemonic!)?
hemolysis IS D PAIN
inh, sulfonamides, dapsone, primarquine, aspirin, ibuprofen, nitrofurantoin
What is the most appropriate initial test for patients with suspected hemolytic episode due G6PD deficiency?
perpiheral blood smear
What test is diagnostic for G6PD deficiency? When should the test be performed?
quantification of g6pd with enzyme assay
What psychiatric disorders have been associated with mitral valve prolapse?
anxiety/panic
What is mitral valve prolapse and what is its cause?
prolapse of mitral valve intro atrium during systole
cause: excess leaflet tissue or myxomatous degen of valve or chodae tedinae
What is the murmur of mitral valve prolapse?
midsystolic or late systolic click
mid-to-late systolic murmur
MVP symptoms
asymptomatic
palpitations, chest pain
myxomatous degeneration
increase in spongiosa (dermatan sulfate)
decrease in fibrosa
increased size
What is the effect of standing and valsalva on the murmur of mitral valve prolapse?
decrease preload
decrease LVV
cordae tendinae slack
makes murmur louder
What is the effect of squatting on the murmur of mitral valve prolapse?
increase preload
increase LVV
tighten mitral apparatus
delays click, quieter murmur
conjugated, direct bilirubin
water soluble
non toxic
unconjugated indirect bilirubin
not soluble in water
neurotoxic
hepatocytes convert
indirect –> direct
How is hyperbilirubinemia diagnosed in an infant?
nomogram (age in hrs)
Elevated indirect bilirubin and absence of bilirubin in the urine indicates what 2 possible processes?
Excess bilirubin production (likely due to hemolysis) OR
Impaired uptake/conjugation by the liver (e.g. Gilbert’s, Crigler-Najjar, or physiologic in the newborn)
What are the three patterns of hyperbilirubinemia?
obstructive
hepatocellular
hemolytic
hepatocellular jaundice
mixed direct/indirect
increased urine bilil
increase urine urobili to nromal
obstructive jaundice
increased direct
increased urine bili
decreased urobili
urobili formed in
intestines
What are possible treatments for a neonate with hyperbilirubinemia?
id cause
nothing/phototherapy/blood transfusion
hemolytic jaundice
increased indirect
no urine bili
increased urine bili
jaundice =
yellow
dark colored urine
light colored stool
pruritis
Elevated direct bilirubin and presence of bilirubin in the urine indicates what 2 possible processes?
intrahepatic
extrahepatic obstruction
In a patient with ADPKD (autosomal dominant polycystic kidney disease), when does renal function start to decrease?
40s-50s
What are the first-line agents in treating hypertension in ADPKD?
ACEI/ARB
What are the possible complications associated with autosomal-dominant polycystic kidney disease?
renal/liver failure
stroke/mi
ruptured intracrainial aneurysm
RCC
Aside from imaging and genetic testing, what other tests may be performed to aid in the diagnosis of autosomal dominant polycystic kidney disease?
urinalysis/culture
gfr
cbc
serum calcium/phosphorus
What 2 mutations are associated with autosomal-dominant kidney disease?
PKD1 polycystin-1
PKD2 polycystin 2
In general, development of renal cysts leads to the development of what structural and physiological defects?
massive bilateral kidney enlargement
destruction of renal parenchyma
renal failure
What are the common causes of renal failure in patients with autosomal dominant polycystic kidney disease (ADPKD)?
pyelonephritis
nephrolithiasis
What is the most common presenting symptom in patients with autosomal dominant polycystic kidney disease and what other symptoms can accompany it?
hypertension
abd mass
polyuria/flank pain/polydipsia
polycystin
transmembrane protein important for CT cohestion
What are some common extra-renal findings in autosomal dominant polycystic kidney disease?
extrarenal cysts (liver, pancreas, spleen)
berry aneursyms
MVP
colonic diverticular
isolated systolic hypertension
decreased elasticity of arterial wall
malloy weiss tears
after repeated vomitting
immobilization can cause
hypercalecemia due to increased osteoclastic activity
lactose interolance testing
+ hydrogen breath test
+ stool for reducing substances
low stool pH
increased stool osmotic gap
leukemoid reaction
increase in leukocytes due to severe infection/inflamm
increased leukocyte alkaline phosphatase score
primary parahyperthyroidism sympstoms
hypercalcemia
kidney stones
neuropsych
HTN
scleroderma esophageal dysmotility manometry
absence of peristaltic waves in lower 2/3
decrease in LES tone
hyperthyroidism with reduce radioactive iodine uptake
subacute granulomatous thyroiditis (deq’s)
synthyroid overdose
iodine-induced thyrotoxicsosis
estrogen and thyroid hormones
increase TBG concentration
need to increase synthroid dose
after trauma with fluid resustication, what might be present on urinalysis
hypovolemia = atn
muddy brown casts
causes hyponatremia with <100 serum Osm
primary polydisia
malnutrition (beer potmania)
aspirin exacerbated resp disease
pseudoallergic rxn
asthma, chronic rhinosinusitis with nasal polyposis
Esophageal strictures
circumferential narrowing
dysphagia to solids
hematuria following pharyngitis
IgA nephropathy
hemodilaysis indictations
refractory hyperkalemia/metabolic acidosis
volume overload/pulm edema
uremic pericarditis, encephalopathy, neuropathy
coagulopathy due to RF
membranoproliferative gluomerolonephritis
dense deposits within GBM
increased C3 - activation of complement system
methimazole AE
agranulocytosis
differential with peluritic pain with IV druge use
infective endocarditis
contact lens associated keratitis
pseudomonas, serratia
post cholecystectomy pain
dysfunction of sphincter of oddi
chondrocalcinosis
pseudogout
high velcoity eye injury - next step
slit lamp (flurocein exam)
otitis externa treatment
ciprofloxacin
cupping of optic disc
open angle glaucoma
erysipelas
sharply demarcated
raised borders
fevers and chills
GAS - pyogenes