Final round

Question 1

which immune cells express TLR4, Siglec-1 and Siglec-7?

Answer 1

TLR4; expressed on monocytes, macorphages, dendritic cells and neutrophils
Siglec-1; expressed on macrophages
Siglec-7; expressed on monocytes, dendritic cells and NK cells and recognizes a2,8 sialic acid

Question 2

describe the critical viral properties that is required for each of the three stages of transmission (respiratory, fecal-oral, sexual)

Answer 2

donor
interface
recipient

Question 3

name the 4 stages of M-pox pathology

Answer 3

incubation, prodromal, rash; papules and vesicles, desquamation; peeling of lesions

Question 4

what happens when there is a mutation in TPMT when administering azathioprine, what is the function of this drug and what is a side effect?

Answer 4

6-mercaptopurine cannot be converted into 6-methylmercaptopurine, inhibit lymphocyte proliferation, hematologic toxicity, PM; lower dose

Question 5

which T cell subsets are involved in sarcoidosis?

Answer 5

Th1-driven (IFNy) Th17 (IL-17a), reduced CTLA-4 expression

Question 6

which cytokines are involved in T2 low and high asthma?

Answer 6

low: IFNy and IL17A
high: IL4/5/9/13 and ILC-2

Question 7

which cytokines are involved in RA?

Answer 7

IL-23-driven (Th17) and IL-12/Th1

Question 8

which T cell subsets and cytokines are involved in Psoriasis?

Answer 8

Th1/17/22 and IL-17A/22/23 and TNF

Question 9

which T cell subsets and cytokines are involved in atopic dermatitis?

Answer 9

Th2/22 early and Th1/17 late, IL4/5/13/22/31/33 and TLSP

Question 10

what is a treatment for IBD?

Answer 10

infliximab (anti-TNF)

Question 11

what are the side-effects of tacrolimus, MMD, prednisolon and azathioprine?

Answer 11

t; nephrotoxicity
MMF; bone marrow toxicity
p; osteoporosis
a; hepatotoxicity