final revision slide Flashcards

1
Q

6 rights of medication error

A
  • right patient
  • right drug
  • right dose
  • right time
  • right route of administration
  • right documentation

4 additional rights incl:

right assessment
right education
right evaluation
right to refuse

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2
Q

what are the 3 checks to avoid medication error

A
  1. Check drug against IMR when removing it from medication drawer, refrigerator or controlled drugs
  2. Check the drug when preparing it, pouring it, taking it out, of the container or connecting the IV tubing to the bag
  3. Check the drug before administration
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3
Q

4 steps to take once error is detected

A
  • check patient for any change of condition/ vital signs
  • inform immediate superior
  • inform doctor
  • write and incident report
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4
Q

impact of medication error

A

patient may suffer morbidity or death which may carry legal implications.

patient may have to stay longer in hospital which results in an increase in healthcare cost and even time separated from family

nurse or doctor making the error may suffer self doubt and embarrassment

nurse or doctor making the error may face disciplinary inquiry

the hospital may suffer negative reputation for being unsafe

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5
Q

purpose of incident report after a medication error

A
  • verify the client’s safety was safeguarded

- serve as a tool to improve drug administration

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6
Q

therapeutic response of most drugs depends on the __________ in the plasma.

A

concentration

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7
Q

the plasma concentration curve, give an indication of _________________ values

A

pharmacokinetics

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8
Q

definition of mimimum effective conc in drug plasma curve

A

amount of drug required to produce a therapeutic effect

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9
Q

definition of minimum effective conc in drug plasma curve

A

amount of drug required to produce a therapeutic effect

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10
Q

definition of therapeutic range in drug plasma curve

A

the range at which the drug produces its desired effect

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11
Q

definition of onset of action

A

represents the amount of time it takes to produce a therapeutic effect after drug administration

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12
Q

definition of onset of action (drug plasma conc)

A

represents the amount of time it takes to produce a therapeutic effect after drug administration

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13
Q

definition of area under the curve

A

the area under the plasma drug conc-time curves reflects the actual body exposure to drug after administration of a dose of the drug

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14
Q

definition duration of drug action

A

-plasma half life. ( T1/2)
Defined as time required for the plasma concentration of a drug to decrease by half. The plasma conc of a drug is halved after one elimination half-life.

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15
Q

for a drug with short-half life, the drug must be given ______ frequently

A

more

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16
Q

for a drug with a long-half life, the drug must be given _______ frequently

A

less

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17
Q

clinical implications of duration of drug action:

A

half-life determines the duration of drug action.

the half-life of a drug depends on its clearance and volume of distribution. the elimination half-life is considered to be independent of the amount of drug in the body.

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18
Q

definition of loading dose

A

higher amount given to ‘prime’ bloodstream

plateau reached faster and quickly produces therapeutic response

important when it is critical to raise the drug plasma quickly.

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19
Q

definition of maintenance dose

A

smaller doses to keep concentration within therapeutic

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20
Q

therapeutic index definition

A

TI is a measure of the safety of a drug. It is he ratio between a drug’s therapeutic benefits and its toxic effects.

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21
Q

therapeutic index

A

median lethal dose/ median effective dose

22
Q

median lethal dose

A

the amount of drug that will be lethal in 50% of a group of animals

23
Q

median effective dose

A

the amount of a drug required to produce a response in 50% of the subjects to whom the drug is given

24
Q

example of medicine with low TI

A

warfarin, anti-epileptics, digoxin, vancomycin

25
Q

larger the difference between the lethal dose and effective dose, the ______ (greater/smaller) the T.I thus the ______ (safer/toxic) the drug

A

greater, safer

26
Q

smaller the difference between the lethal dose and effective dose the ________ (smaller/ greater) the TI , thus more ______ the drug

A

smaller, toxic

27
Q

definition of potency

A

refers to the measure of how much a drug is required in order to produce a particular effect

28
Q

definition of efficacy

A

refers to the magnitude of maximal response that can be produced by the drugs . (the higher the peak, the higher the efficacy)

29
Q

convert 1 mg to g

A

0.001 g

30
Q

convert 1 mg to mcg

A

1000 mcg

31
Q

convert 1 kg to g

A

1000g

32
Q

convert 1g to mg

A

1000 mg

33
Q

convert 1L to mL

A

1000mL

34
Q

convert 1mcL to L

A

0.000001L

35
Q

convert 1mL to L

A

0.001 L

36
Q

general formula for oral tablet / parenteral drug calc

A

number of tablets = prescribed dose (what u want) / tablet strength (what u have avail in the ward )

37
Q

general formula for oral mixture

A

mixture volume =

[ prescribed dose / unit strength] x volume

38
Q

general formula for iv drip rate

A

rate (drops/ min ) = [(total vol (mL) x drops/ mL)]/ [no of hours to run x 60 ]

39
Q

general formula for iv drip rate

A

rate (drops/ min ) = [(total vol (mL) x drops/ mL)]/ [no of hours to run x 60 ]

40
Q

proprietary drugs are also known as

A

brand name, trade name or commercial

41
Q

generic drugs are also known as

A

non-proprietary, approved name or official name

42
Q

trade name is assigned by ________________________. Basically to identify it from other companies that manufacture the same chemical/ drug.

A

assigned by pharmaceutical company that manufactured the product

43
Q

generic name is assigned by the __________________

A

U.S Adopted Name Council

44
Q

the term _____ suggests ownership and the pharmaceutical companies’ exclusive rights (also known as _________) for naming and marketing a drug for a fixed number of years after the new drug application is approved. this exclusive rights allows the drug company to ________________________

A

proprietary, patent ,

recoup the cost of research and development of the drug

45
Q

difference between proprietary and generic drug

A
  • generic drug have identical doses as the trade drug, but their formulations or inert ingredients may differ
  • this difference may change the bioavailability of the drug
  • cost, higher (P) lower (GD)
  • strength of drug , SAME
46
Q

definition of bioavailability

A

bioavailability is defined as the rate and extent to which the active ingredient is absorbed from the drug product and then becomes available at the site of the drug action to produce the desired effects

47
Q

pharmacokinetic considerations in elderly patients

A
  • decreased body water
  • increased body fat as % of body mass
  • increased blood pressure with left ventricular hypertrophy
  • decreased liver function
  • decreased bone density
48
Q

pharmacokinetic considerations in paediatric patients (absorption)

A
  • intestinal mobility
  • gastric acid secretion and pH
  • intestinal motility
  • surface area of GIT
49
Q

pharmacokinetic considerations in paediatric patients (distribution)

A
  • children have higher % of water in body composition which can affect distribution of drugs
  • higher doses of water-soluble drug may be needed
  • less effective BBB in infants
50
Q

pharmacokinetics consideration in paediatric patients (metabolism)

A
  • hepatic metabolism is reduced in young children
51
Q

pharmacokinetics consideration in paediatric patients (metabolism)

A
  • drugs have a longer half-life in children due to slower drug to slower drug clearance and excretion.