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Biochemistry > Final Exam - Exam 1 Review > Flashcards

Final Exam - Exam 1 Review Flashcards

1
Q

Which of the following statements if false?
Select one:

a. Heme (or protophoryrin ring) is synthesized from Succinyl-CoA and Glyicine.
b. 65% of the enzymes have His-Arg-Cys-Glu-Asp in the active site.
c. Hemoglobin can be given as an example of a molecule that exhibits allosterism.
d. Bohr’s effect is observed in both Myoglobin and Hemoglobin.

A

d. Bohr’s effect is observed in both Myoglobin and Hemoglobin.

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2
Q

Glutathione peroxidase catalyzes which of the following type of reaction? Select one:

a. H2 + 1⁄2 O2 → H2O
b. H2 + O2 → H2O2
c. H2O2 + AH2 → 2H2O + A
d. 2H2O2 → 2H2O + O2

A

c. H2O2 + AH2 → 2H2O + A

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3
Q

Which of the following is associated with noncompetitive inhibition? Select one:

a. allosterism

b. allotropism
c. isomerization
d. racemization

A

a. allosterism

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4
Q

Catalase is used as an enzyme for which of the following type of reaction? Select one:

a. H2 + 1⁄2 O2 → H2O
b. H2 + O2 → H2O2
c. H2O2 + AH2 → 2H2O + A
d. 2H2O2 → 2H2O + O2

A

d. 2H2O2 → 2H2O + O2

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5
Q

In which of the following is the Histidine (His F8) replaced by tyrosine?

Select one:

a. Methemoglobinemia
b. Thalassemias
c. Hemoglobin S
d. Hemoglobin M

A

d. Hemoglobin M

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6
Q

Which of the following amino acids not only has a 2o amine group attached directly to the alpha carbon but is also hydroxylated in collagen?

Select one:

a. His (Histidine)
b. Pro (Proline)
c. Val (Valine)
d. Arg (Arginine)

A

b. Pro (Proline)

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7
Q

In which type of inhibition is it not possible to restore the maximum rate of enzyme activity by adding additional substrate? Select one:

a. cooperative inhibition
b. competitive inhibition
c. noncompetitive inhibition
d. selective inhibition

A

c. noncompetitive inhibition

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8
Q

Enzyme : Xanthine oxidase is used for which of the following reactions?
Select one:

a. Oxidation of Purine
b. Oxidation of Pyrimidine
c. Oxidative deamination of amino acids d. Oxidative amidation of amino acids

A

a. Oxidation of Purine

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9
Q

Consider the Bohr’s effect exhibited by Hemoglobin. Which of the following is true for Hemoglobin?
Select one:

a. Increase in [CO2] and decrease in pH value will help buffering action.
b. Amino acid His-146 on the alpha chain gets protonated and forms a salt bridge with the amino acid, Asp. c. There are 2 moles of protons being transported by His-146 on the alpha chain.
d. Decrease in [CO2] and increase in pH value will help buffering action.

A

a. Increase in [CO2] and decrease in pH value will help buffering action.

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10
Q

The porphyrin ring around the central Fe atom in hemoglobin is also called as the
Select one:

a. Tripyrrole
b. Tetrapyrrole
c. Pentapyrrole
d. Tetrapyrrolidine

A

b. Tetrapyrrole

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11
Q

The co-enzyme, NAD+ is classified as which of the following oxido-reductase enzyme? Select one:

a. Oxygenase

b. Oxidase
c. Hydroperoxidase
d. Dehydrogenase

A

d. Dehydrogenase

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12
Q

A number of compounds inhibit oxidative phosphorylation—the synthesis of ATP from ADP and inorganic phosphate linked to oxidation of substrates in mitochondriA. Which of the following describes the action of an uncoupler?
Select one:

a. It discharges the proton gradient across the mitochondrial outer membrane.
b. It inhibits the electron transport chain directly by binding to one of the electron carriers in the mitochondrial inner membrane.
c. It discharges the proton gradient across the mitochondrial inner membrane.

A

c. It discharges the proton gradient across the mitochondrial inner membrane.

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13
Q

Which of the following statements is false?
Select one:

a. Collagen is not synthesized as a larger precursor.
b. Alzheimer’s disease is related to refolding or misfolding of another protein endogenous to human brain tissue, beta amyloiD.
c. Beta thalassemias are caused by genetic defects that impair the synthesis of one of the polypeptide subunits of hemoglobin.
d. Prion diseases may manifest themselves as infectious, genetic or sporadic disorders.

A

a. Collagen is not synthesized as a larger precursor.

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14
Q

Which of the following amino acids has an acidic side chain?
Select one:

a. Ala
b. Val
c. Gln
d. Glu

A

d. Glu

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15
Q

Which of the following is true of all allosteric enzymes?

a. They consist of proteins only.

b. They have a nonprotein portion.
c. They have more than one active site on each subunit.
d. Binding at one site affects protein function at a second site.

A

d. Binding at one site affects protein function at a second site.

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16
Q

Cytochrome P450 is classified as ____________________
Select one:

a. Dehydrogenase
b. Monooxygenase
c. Dioxygenase
d. Hydroperoxidase

A

b. Monooxygenase

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17
Q

In oxidative phosphorylation, ATP synthase produced how many moles of ATP ?
Select one:

a. 1 mole
b. 2 moles
c. 3 moles
d. 4 moles

A

c. 3 moles

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18
Q

The hydrogen bond in the a-helix is between which two species
Select one:

a. CO and NH
b. CO and CO
c. CO and H
d. NH and NH

A

a. CO and NH

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19
Q

Which of the following amino acids can form a covalent bond with another amino acid? Select one:

a. Glycine (Gly)
b. Methionine (Met)
c. Cysteine (Cys)
d. Alanine (Ala)

A

c. Cysteine (Cys)

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20
Q

Which of the following will the cause the rate of enzyme activity to first increase and then level off?
Select one:

a. increasing the enzyme concentration
b. increasing the substrate concentration
c. increasing the temperature
d. increasing the pH

A

b. increasing the substrate concentration

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21
Q

When blood glucose enter the erythrocytes, it glycates the pendant group of which amino acid?
Select one:

a. Arginine
b. Lysine
c. Glutamine
d. None of these

A

b. Lysine

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22
Q

Identify the Amino acid that is responsible for PKU
Select one:

a. His
b. Val
c. Phe
d. Ala

A

c. Phe

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23
Q

Which one of the following statement is False (or not correct) Select one:

a. Interconvertible enzymes fulfill key roles in integrated regulatory networks.

b. Phosphorylation of an enzyme often alters its catalytic effiiciency.
c. The ability of protein kinases to catalyze the reverse reaction that removes the phosphoryl group is key to the versatility of this molecular regulatory mechanism.
d. Zymogen activation by partial proteolysis is irreversible under physiological conditions

A

a. Interconvertible enzymes fulfill key roles in integrated regulatory networks.

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24
Q

I need to isolate Alanine from the following tetrapeptide: AlnylSerylValylGlycine. Which enzyme would I use?
Select one:

a. Carboxypeptidase
b. Aminopeptidase

A

b. Aminopeptidase

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25
Q

Which of the following statements about toxins in the oxidative phosphorylation process is true?
Select one:

a. H2S, CO, CN- ion inhibit Complex III
b. Barbiturates inhibit electron transport via Complex I
c. Malonate is a noncompetitive inhibitor for Complex III
d. Oligomycin blocks reduction and phosphorylations reactions in ATP synthase

A

b. Barbiturates inhibit electron transport via Complex I

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26
Q

HIV protease illustrates an example of which of the following type of catalysis?
Select one:

a. Acid-base catalysis
b. Covalent catalysis
c. Catalysis by strain
d. Catalysis by proximity

A

a. Acid-base catalysis

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27
Q

Reduced production of a and b subunits of HbA results in
Select one:

a. Methemoglobinemia
b. Polycythemia
c. Alpha and beta thalassemia
d. None of these

A

c. Alpha and beta thalassemia

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28
Q

Complex II refers to which of the following enzyme system?
Select one:

a. NADH-Q oxidoreductase
b. Q-Cyt C oxidoreductase
c. Cyt C oxidase
d. Succinate-Q reductase

A

d. Succinate-Q reductase

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29
Q

Peroxisomes are rich in oxidases and which of the following enzymes?
Select one:

a. Dehydrogenases
b. Oxygenases
c. Peroxidase
d. Catalase

A

d. Catalase

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30
Q

Which of the following generally refers to beta bends or turns?
Select one:
a. Joining of two polypeptide beta pleated sheets with 4 aminoacyl residues
b. Joining of two polypeptide beta pleated sheets with more than 4 aminoacyl residues

A

a. Joining of two polypeptide beta pleated sheets with 4 aminoacyl residues

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31
Q

Select which one of the following statements is False (or not correct).
Select one:

a. If the pKa of a weak acid is 4.0, 50% of the molecules will be in the dissociated state when the pH of the surrounding environment is 4.0.
b. A weak acid with a pKa of 4.0 will be a more effective buffer at pH 3.8 than at pH 5.7.
c. At a pH equal to its pI a polypeptide carries no charged groups.
d. The pKa of an ionizable group can be influenced by the physical and chemical properties of its surrounding environment.

A

C. At a pH equal to its pI a polypeptide carries no charged groups.

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32
Q

Which amino acid has an indole ring in the side chain at the alpha carbon?
Select one:

a. Ala (Alanine)
b. Pro (Proline)
c. Trp (Tryptophan)
d. Tyrosine

A

c. Trp (Tryptophan)

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33
Q

Which of the following amino acids from an enzyme can exhibit protein modification?
Select one:

a. Met
b. Ser
c. Phe
d. Lys

A

b. Ser

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34
Q

Which of the following conversions occur in Complex II?
Select one:

a. FAD to FADH2
b. Fumarate to Succinate
c. NADH to NAD
d. FADH2 to FAD

A

d. FADH2 to FAD

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35
Q

The pI of an amino acid with three ionizable groups is given as 8.0. Which of the following is true of the structure of the amino acid?
Select one:

a. Has a non polar side chain
b. Has an acidic side chain
c. Has a basic side chain
d. Has no side chain

A

c. Has a basic side chain

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36
Q

In addition to proteins, which type of molecules sometimes function as enzymes?
Select one:

a. carbohydrates
b. DNA
c. lipids
d. RNA

A

d. RNA

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37
Q

In which case is the hydrogen bond oriented perpendicular to the backbone of the polypeptide (or forms a more regular structure)?
Select one:

a. Antiparallel beta sheet
b. Parallel beta sheet

A

a. Antiparallel beta sheet

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38
Q

Most biomolecules are
Select one:

a. Amphiprotic
b. Apathetic
c. Amphitheatric
d. Amphipathic

A

d. Amphipathic

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39
Q

Which of the following is true of enzymes?
Select one:

a. They lower the activation energy for a chemical reaction.
b. They speed up the rate of a chemical reaction.
c. both a and b
d. neither a nor b

A

c. both a and b

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40
Q

Select which one of the following statements is False (or not correct).
Select one:

a. Glycine is not present in regions where a polypeptide forms a sharp bend, reversing the direction of a polypeptide.
b. Polypeptides are named as derivatives of the C-terminal aminoacyl residue.
c. The C, N, O, and H atoms of a peptide bond are coplanar.
d. A linear pentapeptide contains four peptide bonds.

A

a. Glycine is not present in regions where a polypeptide forms a sharp bend, reversing the direction of a polypeptide.

41
Q

Which of the following is true?
Select one:

a. Both competitive and noncompetitive inhibition are never reversible.
b. Both competitive and noncompetitive inhibition are sometimes reversible.
c. Only competitive inhibition is sometimes reversible.
d. Only noncompetitive inhibition is sometimes reversible.

A

b. Both competitive and noncompetitive inhibition are sometimes reversible.

42
Q

Which types of amino acids interact most strongly with metal ions?
Select one:

a. those with acidic side chains
b. those with basic side chains
c. those with nonpolar side chains
d. those with polar side chains

A

a. those with acidic side chains

43
Q

Enzyme : L-Aminoacid oxidase is used for which of the following reactions?
Select one:

a. Oxidation of Purine
b. Oxidation of Pyrimidine
c. Oxidative deamination of amino acids
d. Oxidative amidation of amino acids

A

c. Oxidative deamination of amino acids

44
Q

The propensity of water molecules to form hydrogen bonds with one another is the primary factor responsible for all of the following properties of water EXCEPT:
Select one:

a. Its atypically high boiling point.
b. Its high heat of vaporization.
c. Its high surface tension.
d. Its ability to dissolve hydrocarbons.

A

d. Its ability to dissolve hydrocarbons.

45
Q

Which of the following statements is false?
Select one:

a. Glycine+Arginine+S-Adenosylmethionine can be used to make Creatine.
b. Serotonin can be made by decarboxylation of 5-hydroxytrytophan.
c. Melatonin is a derivative of (or can be synthesized from) amino acid, Tyr.
d. Melatonin is synthesized by Acetylation of the amine group and methylation of the hydroxyl group of Serotonin.

A

c. Melatonin is a derivative of (or can be synthesized from) amino acid, Tyr.

46
Q

An increased concentration of erythrocytes because of mutations of hemoglobin results in which disease?
Select one:

a. Methemoglobinemia
b. Hemoglobin S
c. Polycythemia
d. Hemoglobin M

A

c. Polycythemia

47
Q

A student takes some tablets she is offered at a disco, and without asking what they are she swallows them. A short time later she starts to hyperventilate, and becomes very hot. What is the most likely action of the tablets she has taken?
Select one:

a. An uncoupler of mitochondrial electron transport and oxidative phosphorylation
b. An inhibitor of mitochondrial electron transport
c. An inhibitor of the transport of ADP into mitochondria to be phosphorylated
d. An inhibitor of the transport of ATP out of mitochondria into the cytosol

A

a. An uncoupler of mitochondrial electron transport and oxidative phosphorylation

48
Q

Which one of the following statement about cytochromes P450 is INCORRECT?
Select one:

a. They are able to accept electrons from either NADH or NADPH.
b. They are found only in the endoplasmic reticulum.
c. They are monooxygenase enzymes.
d. They play a major role in drug detoxification in the liver.

A

b. They are found only in the endoplasmic reticulum.

49
Q

Select which one of the following statements is false (or not correct).
Select one:

a. Buffers of human tissue include bicarbonate, proteins, and orthophosphate.
b. A weak acid or a weak base exhibits its greatest buffering capacity when the pH is equal to its pKa plus or minus one pH unit.
c. The isoelectric pH (pI) of lysine can be calculated using the formula (pK2 + pK3)/2.
d. The mobility of a monofunctional weak acid in a direct current electrical field reaches its maximum when the pH of its surrounding environment is equal to its pKA.

A

d. The mobility of a monofunctional weak acid in a direct current electrical field reaches its maximum when the pH of its surrounding environment is equal to its pKA.

50
Q

What disease is diagnosed by monitoring acid phosphatase activity?
Select one:

a. hepatitis
b. liver cancer
c. pancreatic disease
d. prostate cancer

A

d. prostate cancer

51
Q

Which of the following statements is false?
Select one:

a. Enzymes employ the following mechanisms to facilitate catalysis: proximity, acid-base, strain and covalent catalysis.
b. 2,3-BPG in the central cavity of deoxyHb forms salt bonds with the beta subunits that stabilize deoxyHB.
c. Superoxide dismutase (SOD) reduces superoxide and also reduces the Fe+3 in Cytochrome C.
d. Cytochrome oxidase is not classified as a hemoprotein.

A

d. Cytochrome oxidase is not classified as a hemoprotein.

52
Q

Which of the following amino acids will exhibit a hydrophobic interaction between itself and Valine?
Select one:

a. Lys (Lysine)
b. Asp (Aspartic acid)
c. Glu (Glutamic acid)
d. Ala (Alanine)

A

d. Ala (Alanine)

53
Q

Which of the following can cause enzyme activity to either increase or decrease?
Select one:

a. changing the temperature
b. increasing the substrate concentration
c. both a and b
d. neither a nor b

A

a. changing the temperature

54
Q

Which of the following amino acids has a benzene and a pyrrole ring fused together and can be used to make serotonin?
Select one:

a. Isoleucine (Ile)
b. Tryptophan (Trp)
c. Histidine (His)
d. None of these

A

b. Tryptophan (Trp)

55
Q

Which one of the following statements is False (or not correct):
Select one:

a. Many mitochondrial proteins are covalently modified by the acetylation of the epsilon-amino groups of lysine residues.
b. Protein acetylation is an example of a covalent modification that can be “reversed” under physiological conditions.
c. Increased levels of acetyl-CoA tend to favor protein acetylation.
d. The side chain of an acetylated lysyl residue is a stronger base than that of an unmodified lysyl residue

A

d. The side chain of an acetylated lysyl residue is a stronger base than that of an unmodified lysyl residue

56
Q

Which of the following statements is False?
Select one:

a. NAD+ is generally used for the oxidation of alcohols.
b. FAD is generally used for oxidation by removing 2H’s from adjacent carbon atoms.
c. Cytochromes may also be regarded as dehydrogenases.
d. Peroxidases reduce peroxides using H2O2 as an electron donor as well as acceptor.

A

d. Peroxidases reduce peroxides using H2O2 as an electron donor as well as acceptor.

57
Q

Cytochrome P450 is classified as which of the following?
Select one:

a. Monooxygenase
b. Dioxygenase

A

a. Monooxygenase

58
Q

In Oxidative phosphorylation process, which of the following complexes does not have the potential to push protons into the intermembrane space?
Select one:

a. Complex I
b. Complex II
c. Complex III
d. Complex IV

A

b. Complex II

59
Q

In the citric acid cycle, which of the following statement is true?
Select one:
a. NADH is used in the process of oxidation of Malate to Oxaloacetate.
b. FAD is used in the process of reduction of succinate to fumarate
c. Malate dehydrogenase, isocitrate dehydrogenase and succinate dehydrogenase all use NAD+ for oxidation/reduction reactions.
d. NAD+ is used for the oxidation of Isocitrate to Oxalosuccinate (or ketoglutarate)

A

d. NAD+ is used for the oxidation of Isocitrate to Oxalosuccinate (or ketoglutarate)

60
Q

Which of the following statements is false?
Select one:

a. Amino acid, Cys can be used to synthesize Taurine.
b. Amino acid, Phe can be used to synthesize Catecholamines.
c. Amino acid, Glu can be used to synthesize GABA (Gamma aminobutyrate)
d. Amino acid, Trp can be used to synthesize Catecholamines.

A

d. Amino acid, Trp can be used to synthesize Catecholamines.

61
Q

Which of the following is true of isozymes?
Select one:

a. Their amino acid sequences are mirror images of one another.
b. They are a pair of enzymes which must both be present for enzyme activity to occur.
c. They are different forms of the same enzyme found in different tissues.
d. None of the above is true.

A

c. They are different forms of the same enzyme found in different tissues.

62
Q

Which of the following is commonly associated with protein modification?
Select one:

a. phosphorylation
b. dephosphorylation
c. both a and b
d. neither a nor b

A

c. both a and b

63
Q

Which of the following reactions occur in Complex IV?
Select one:

a. Reduction of H2O
b. Oxidation of O2
c. Reduction of O2
d. Reduction of Cytochrome C

A

c. Reduction of O2

64
Q

Which of the following can denature the disulfide bond in peptides?
Select one:

a. Heat
b. Heavy metal ions
c. Urea
d. Reducing agents


A

d. Reducing agents

65
Q

CO2 is carried by deoxyhemoglobin as which of the following functional groups?
Select one:

a. CO2
b. Carbamate
c. Carbonate
d. Bicarbonate

A

b. Carbamate

66
Q

The greatest quantitative source of ATP is which of the following?
Select one:

a. Citric acid cycle
b. Glycolysis
c. Oxidative phosphorylation
d. Hydrolysis of Creatine phosphate to Creatine.

A

c. Oxidative phosphorylation

67
Q

The enzyme Aldehyde dehydrogenase carries out which of the following reactions?
Select one:

a. Oxidation of aldehyde to acid
b. Reduction of aldehyde to alcohol

A

a. Oxidation of aldehyde to acid

68
Q

Replacing the 6th amino acid of the beta chain of Glu of HbA with Val results in which of the following disease? Select one:

a. Polycythemia

b. Hemoglobin M
c. Methemoglobinemia
d. Sickle Cell anemia

A

d. Sickle Cell anemia

69
Q

Competitive inhibition can be explained by which of the following models?
Select one:

a. the induced fit model
b. the lock and key model
c. both a and b
d. neither a nor b

A

c. both a and b

70
Q

Tyrosine-tRNA synthetase belongs to which group of enzymes?
Select one:

a. hydrolases
b. ligases
c. oxidoreductases
d. transferases

A

b. ligases

71
Q

Complex I oxidizes which of the following molecules?
Select one:

a. NADH
b. FADH2
c. FAD
d. NAD+

A

a. NADH

72
Q

Cytochrome aa3 is classified as which of the following? Select one:

a. Oxidase

b. Oxygenase
c. Peroxidase
d. Catalase

A

a. Oxidase

73
Q

Which of the following statements is false?
Select one:

a. Arginine is used to make NO (Nitric oxide) by the action of NO Synthase.
b. Cysteine participates in the biosynthesis of Coenzyme A
c. Decarboxylation of amino acid, His forms Histamine
d. Amino acid, Tyr is used by neural cells to form only norepinephrine and not epinephrine.

A

d. Amino acid, Tyr is used by neural cells to form only norepinephrine and not epinephrine.

74
Q

An enzyme called as the hydroxylase would be classified as which of the following?
Select one:

a. Monooxygenase
b. Dioxygenase

A

a. Monooxygenase

75
Q

Which of the following amino acids has a pyrrolidine side chain? Select one:

a. Lysine
b. Arginine
c. Histidine
d. Proline

A

d. Proline

76
Q

Which of the following amino acids has an aliphatic side chain? Select one:

a. Serine
b. Threonine
c. Asparagine
d. Isoleucine

A

d. Isoleucine

77
Q

2,3-BPG forms what kinds of bonds to stabilize itself with the beta chain of deoxyhemoglobin?
Select one:

a. Metal ion co-ordination
b. Covalent bond formation
c. Electrostatic forces of attraction
d. Hydrogen bonds

A

c. Electrostatic forces of attraction

78
Q

Acetylcholinesterase belongs to which group of enzymes?
Select one:

a. hydrolases
b. lyases
c. oxidoreductases
d. transferases

A

a. hydrolases

79
Q

An enzyme converts Acetyl CoA (CH3-CO-SCoA) into Acetic acid and CoA-SH. Which of the following categories does this enzyme belong to?
Select one:

a. Oxidoreductase
b. Hydrolase
c. Lyase
d. Ligase

A

b. Hydrolase

80
Q

In the Henderson Hasselbach equation, if the [A-] is equal to [HA], which of the following relationship holds true?
Select one:

a. pH greater than pKa
b. pH less than pKa
c. pH equal pKa
d. No relationship between molar concentration of the ions and pH

A

c. pH equal pKa

81
Q

When a mutation compromises biologic function of HbA, the condition is termed
Select one:

a. Homeopathy
b. Myoglobinopathy
c. Hemoglobinopathy
d. Mutaopathy

A

c. Hemoglobinopathy

82
Q

Which of the following statements is false?
Select one:

a. Prosthetic groups are tightly integrated into an enzyme’s structure
b. Cofactors are tightly integrated into an enzyme’s structure
c. Coenzymes are derivatives of B vitamins.
d. Substrates induce conformation changes in enzymes.

A

b. Cofactors are tightly integrated into an enzyme’s structure

83
Q

Which one of the following statement about cytochromes is INCORRECT?
Select one:

a. They are hemoproteins that take part in oxidation-reduction reactions.
b. They are all dehydrogenase enzymes
c. They act as electron carriers in the respiratory chain in mitochondriA.
d. They have an important role in the hydroxylation of steroids in the endoplasmic reticulum.

A

b. They are all dehydrogenase enzymes

84
Q

Which one of the following enzymes uses molecular oxygen as a hydrogen acceptor?
Select one:

a. Cytochrome c oxidase
b. Isocitrate dehydrogenase
c. Catalase
d. Superoxide dismutase

A

A. Cytochrome c oxidase

85
Q

A number of compounds inhibit oxidative phosphorylation—the synthesis of ATP from ADP and inorganic phosphate linked to oxidation of substrates in mitochondriA. Which of the following describes the action of oligomycin?
Select one:

a. It discharges the proton gradient across the mitochondrial inner membrane.
b. It inhibits the electron transport chain directly by binding to one of the electron carriers in the mitochondrial inner membrane.
c. It inhibits the transport of ADP into, and ATP out of, the mitochondrial matrix.
d. It inhibits the transport of protons back into the mitochondrial matrix through ATP synthase.

A

d. It inhibits the transport of protons back into the mitochondrial matrix through ATP synthase.

86
Q

Flavoproteins are classified as___________
Select one:

a. Dehydrogenases
b. Oxidases
c. Hydroperoxidases
d. Oxygeneases

A

b. Oxidases

87
Q

Aspartate transaminase belongs to which group of enzymes?
Select one:

a. hydrolases
b. lyases
c. oxidoreductases
d. transferases

A

d. transferases

88
Q

In which of the following complexes (or enzymes complexes) is the Q (Ubiquinone or Co-Q) reduced?
Select one:

a. Complex I and II
b. Complex I, II and III
c. Complex I, II, III and IV
d. Complex III and IV

A

a. Complex I and II

89
Q

Which of the following statements is true?
Select one:

a. Citrate synthase (oxaloacetate to citrate) is classified as an Oxidoreductase
b. Fumarase (Fumarate to Malate) is classified as ligase
c. Succinate thiokinase (Succinyl CoA to Succinate) is classified as a hydrolase and a transferase
d. Malate Dehydrogenase (Malate to oxaloacetate) is classified as a transferase.

A

c. Succinate thiokinase (Succinyl CoA to Succinate) is classified as a hydrolase and a transferase

90
Q

What disease is diagnosed by monitoring amylase activity?
Select one:

a. hepatitis
b. liver cancer
c. pancreatic disease
d. prostate cancer

A

c. pancreatic disease

91
Q 
In an ATP molecule, the heterocyclic base is not made from which of the following amino acid (or which of the following amino acids do not take part in the biosynthesis of a purine molecule)?
Select one: 
a. Gly
b. Asp 
c. Gln 
d. Asn
A

d. Asn

92
Q

Which of the following statements is False? Select one:

a. Oxidases uses atmospheric oxygen for oxidation reactions
b. Dehydrogenases uses atmospheric oxygen for oxidation reactions
c. Peroxidases hydrolyzes H2O2 to H2O
d. Catalase hydrolyzes H2O2 to O2 and H2O

A

b. Dehydrogenases uses atmospheric oxygen for oxidation reactions

93
Q

Which one of the following statements is False (or not correct).
Select one:

a. Steric hindrance by histidine E7 plays a critical role in weakening the affinity of hemoglobin or carbon monoxide (CO).
b. Carbonic anhydrase plays a critical role in respiration by virtue of its capacity to break down 2,3-bisphosphoglycerate in the lungs.
c. Hemoglobin S is distinguished by a genetic mutation that substitutes Glu6 on the β subunit with Val, creating a sticky patch on its sur ace.
d. Oxidation of the heme iron from +2 to the +3 state removes (or disables) the ability of hemoglobin to bind oxygen.

A

b. Carbonic anhydrase plays a critical role in respiration by virtue of its capacity to break down 2,3-bisphosphoglycerate in the lungs.

94
Q

Which of the following is the reason that trypsin is synthesized as trypsinogen?
Select one:

a. It is simpler to synthesize trypsinogen.
b. Trypsinogen is a more active enzyme than trypsin.
c. Trypsin would attack the body’s natural proteins.
d. Trypsin is a larger molecule than trypsinogen.

A

c. Trypsin would attack the body’s natural proteins.

95
Q

Which of the following amino acid combinations can be used as an example of electrostatic interactions?
Select one:

a. Glutamic acid and Lysine
b. Lysine and Arginine
c. Glutamic acid and Aspartic acid
d. None of these

A

a. Glutamic acid and Lysine

96
Q

The CO2 released from tissues and carried by HbA attaches to the N-terminal or the C-terminal of the polypeptide chains? Select one:

a. N-terminal as carboxylate
b. C-terminal as carboxylate
c. N-terminal as carbamate
d. C-terminal as carbamate

A

c. N-terminal as carbamate

97
Q

Chymotrypsin illustrates an example of which of the following types of catalysis?
Select one:

a. Acid base catalysis
b. Covalent Catalysis
c. Catalysis by strain
d. Catalysis by proximity

A

b. Covalent Catalysis

98
Q

Which of the following is true about the following isoenzymes?
Select one:

a. Lactate Dehydrogenase (LDH) has 3 isoenzymes and Creatine Kinase (CK) has five isoenzymes
b. Levels of LDH isoenzymes help identify a particular injured tissue, while CK-MB has a useful diagnostic window and is found predominantly in the heart and skeletal muscle.
c. In LDH, isozyme I1 or H4 is found predominantly in the liver and isozyme, I5 or M4 is found in the heart.
d. CK-MB is an isoenzyme of CK that has a useful diagnostic window and is found predominantly in the brain tissue.

A

b. Levels of LDH isoenzymes help identify a particular injured tissue, while CK-MB has a useful diagnostic window and is found predominantly in the heart and skeletal muscle.

99
Q

In which type of inhibition does the inhibitor bind to the active site?
Select one:

a. cooperative inhibition
b. competitive inhibition
c. noncompetitive inhibition
d. selective inhibition

A

b. competitive inhibition

Biochemistry (15 decks)

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