Final Exam

Question 1

Von Gierke’s disease is synomymous with a glucose 6-phosphatase deficiency.
True or False.

Answer 1

True

Question 2

Rate limiting enzyme in the pentose phosphate pathway ____.

Answer 2

G6P dehydrogenase

Question 3

Insulin is secreted by alpha cells from the pancreas.

True or False

Answer 3

False

Question 4

Insulin has the following effects:

Answer 4

Increase storage of high energy fuels

Increase glycogenesis

Decrease GNG

Decrease glycogenolysis

Question 5

Cori disease is synonymous with glycogen debranching enzyme.

True or False

Answer 5

True

Question 6

Most common cause of type-2 diabetes

Answer 6

Obesity

Question 7

G6P is converted into G1P via

Answer 7

Phosphoglutomutase

Question 8

Isomers denoted as alpha and beta forms are

Answer 8

Anomers and diastereomers

Question 9

The final products of digestion are

Answer 9

Glucose, galactose, fructose

Question 10

Provides electrons to antioxidant enzymes

Answer 10

NADPH

Question 11

Functions of cytochrome P450 mono-oxygenase include

Answer 11

Biosynth steroid hormones, detox toxins inside smooth ER, and detox drugs inside the smooth ER

Question 12

The unpaired electron in nitrogen monoxide is

Answer 12

A free radical

Question 13

The primary product of the pentose shunt pathway is

Answer 13

Sugars

Question 14

The pathway that is a primary source of ribose in the body is

Answer 14

Pentose shunt pathway

Question 15

2 hormones released in concert with epinephrine and norepinephrine to regulate metabolism

Answer 15

Insulin and glucagon

Question 16

The primary enzyme for glycogen synthesis is

Answer 16

Glycogen synthase

Question 17

The following are products of the pentose phosphate pathway

Answer 17

NADPH, ribose 5-P, CO2

Question 18

NADPH uses include

Answer 18

Phagocytosis by WBCs, cytochrome P40 mono-oxygenase system, and reductive biosynthesis

Question 19

G-protein coupled receptor is associated with

Answer 19

Glucagon and epinephrine

Question 20

Glycogen synthase is active when it is

Answer 20

Dephosphyrolyated by insulin

Question 21

Glycogenolysis occurs in the

Answer 21

Cytosome

Question 22

Processing of preproinsulin to proinsulin occurs in the

Answer 22

Smooth ER

Question 23

Insulin resistance can cause the following effects

Answer 23

Increase adipose lipolysis, increase hepatic gluconeogenesis, increase blood glucose

Question 24

Transport protein associated with skeletal muscle and adipose tissue

Answer 24

Glut-4

Question 25

Catalyzes reaction for the conversion of citrate to isocitrate

Answer 25

Aconitase

Question 26

Nitric oxide is

Answer 26

A vasodilator of smooth muscle

Question 27

Km is unaffected, Vmax is lower with

Answer 27

Non-competitive inhibition

Question 28

If keq < 1 and delta G > 1

Answer 28

The reaction favors the reactants

Question 29

Product of pyruvate oxidation that enters the Krebs Cycle

Answer 29

Acetyl-CoA

Question 30

Monosaccharides can form cyclical structures. | True or False

Answer 30

True

Question 31

What class of enzymes forms C-S, C-O, and C-N bonds between subunits?

Answer 31

Ligase

Question 32

Unique to gluconeogenesis

Answer 32

Oxaloacetate to PEP

Question 33

Enzyme that uses water to remove the phosphoryl group

Answer 33

Phosphatase

Question 34

Pair of mobile electron carriers in the ETC

Answer 34

CoQ and cytochrome C

Question 35

A positive delta G is

Answer 35

A net gain of energy; products have more free energy than reactants

Question 36

The following are components of complex IV of the ETC

Answer 36

Water released, Cyt A3 component, and electrons transferred to molecular oxygen

Question 37

Glycogen synthase is

Answer 37

The enzyme responsible for linking glucose, makes alpha 1-4 linkages, and cannot link free glucose of G1P

Question 38

Amino acid containing a disulfide bond

Answer 38

Cysteine

Question 39

The final processing of proinsulin to insulin takes place in the

Answer 39

Golgi

Question 40

The Krebs cycle takes place in the

Answer 40

Mitochondria

Question 41

The Kreb’s Cycle produces how many ATP for 1 molecule of acetyle-CoA?

Answer 41

24

Question 42

2 vitamins associated with NADH and FADH2

Answer 42

Riboflavin and Niacin

Question 43

Functions as a cofactor that aids in the transfer of CO2 groups

Answer 43

Biotin

Question 44

Product of glycolysis under anaerobic conditions

Answer 44

Lactate

Question 45

Amount of ATP technically made from the TCA cycle

Answer 45

0

Question 46

If keq=1 and delta G=0

Answer 46

A system is in equilibrium

Question 47

Sucrose is a combination of

Answer 47

Fructose + Glucose

Question 48

Glycine is special because

Answer 48

It is achiral, it doesn’t have 4 different bonding sites

Question 49

Allosteric regulation changes

Answer 49

Activity of enzyme by binding an effector

Question 50

Max buffering capacity occurs when

Answer 50

pH=pKa