Final Exam Flashcards
1) What is Akathisia
Inability to sit still or restlessness and is more common in middle-aged patients. Person will pace, rock while sitting or standing, march in place, or corss and uncross the legs. All of these repetitive motions have an intensity that is frequently beyond the explanation of the individual. In addition akathisia may be present as a primarily subjective experience without motor behavior. The subjective experience includes feelings of anxiety, jitterness, or inability to relax, which the individual may or may not be able to express. Most difficult acute medication-related movement disorder to relieve. Pathology may involve more than just extrapyramidal motor system. A number o medications used to reduce symptoms include beta-andrengeric blockers, anticholinergics, antihistamines, and low dose antianxiety agents. Physical and psychological stress appear to increase the symptoms and frighten pt. Risk factors for extrapyramidal symptoms (EPS) include previous episodes of EPS
2) What is Echoalia
Repetition of another’s words that is parrot-like and inappropriate
3) What is Referential Thinking
Belief that neutral stimuli have special meaning to the individual, such as the television commentator speaking directly to the individual.
4) Study extrapyramidal side effects of Antipyschotic medications and treatment for
- Parkinsonism: tends to occur in older pts. Symptoms believed o be caused by blockade of D2 receptors in basal ganglia that throws off Ach and dopamine. Increases Ach transmission. Symptoms managed by reducing dosage of antipsychotic or adding an anticholinergic drug such as benzotropin or trihexyphenidyl
- Abrupt discontinuation of anticholinergic can cause cholinergic rebound and result in withdrawl symptoms (nausea, vomiting, sweating, dreams/nightmares). Drug should be tapered.
- Dystonic reactions believed to result from imbalance of dopamine and Ach. Young men more vulnerable to extrapyramidal side effects. Starts with oculogyric crisis (eye movement control tense and pull eyes to ceiling), torticollis (neck pulled to side) retrocollis (head pulled back) orolaryngealpharyngeal hypertonus (extreme difficulty swallowing), contorted extremities. Immediate treatment is administration on benzotropine or diphenhydramine (Benadryl) followed by daily admin of anticholinergic drugs and decrease in antipsychotic
- Akathisia: restless and feel driven to keep moving. Response misinterpreted as anxiety or increase in psychotic symptoms (potential to be given increase in antipsychotics)
- Tardive dyskinesia, tardive dystonia, tardive akathisia: less likely but possible to appear in second generation antipsychs rather than first generation. Tardive dyskinesia late-appearing abnormal movements involve mouth, tongue, jaw, lip smaking, tongue protrusion
- No consistently effective treatment but antipsychotics ask movements of tardive dyskineasia Best management is using lowest possible dose of antipsychotics that minimizes symptoms
5) Study Neuroleptic Malignant Syndrome
Develops from reaction to antipsychotic medications. Develop severe muscle rigidity with elevated temp and cascade of symptoms (within next 48-72 hrs) and include 2 or more of following: hypertension, tachycardia, tachypnea, diaphoresis, incontinence, mutism, leukocytosis, change in LOC, and lab evidence of muscle injury (incrase creatinine phosphokinase). Most imp aspect of nursing care is early symptom recognition, holding dopamine-blocking antipsychotics and supportive care. Carefully monitor I&O and electrolyte status. Treatment includes admin of dompamine agonist (bromocriptine) and muscle relaxants (dantrolene and benzodiazepine). Some pts see improvement with ECT. Treating temp a priority
6) Study Anticholinergic Crisis
Caused by overdose or sensitivity to drugs with anticholinergic properties. May result from OD of antimuscarinic drugs (atropine, scopolamine, or belladonna). Drugs prescribed in psychiatric setting include TCAand antipsychotics. May produce acute delirium or reaction resembling schizophrenia. Characterized by: elevated temp, parched mouth, burning thirst, hot dry skin, decreased salivation, decreased bronchial and nasal secretions, dilated eyes, increased HR, constipation, htn or hypotension. May be flushed and experience neuropsychiatric symptoms of anxiety (agitation, delirium, hyperactivity, confusion, hallucination, seizures). Typically self-limiting, usually subside within 3 days. After use of drug d/c, improvements generally follow with 24-36 hrs
7) Review the communication technique of Reflection
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8) Study the neurotransmitter-Acetylcholine
Primary cholinergic neurotransmitter. Greatest concentration in PNS. Provides basic synaptic communication. Important role in learning and memory; some role in wakefulness and basic attention; peripherally activates muscles and is major neurotransmitter of the ANS; involved in higher intellectual functioning and memory. Role in communicating emotional state
9) Review Diazepam and side effects
Side effects typically areise within 2-3 weeks after medication begins. Side effects include: appetite suppression, insomnia, irritability, weight loss, nausea, headache, palpitations, blurred vision, dry mouth, constipation, and dizziness. Some experience BP changes, tachycardia, tremors, irregular HR. Monitor height and weight in children Avoid in pts with Tourettes syndrome. Symptoms of OD include: agitation, chest pain, hallucination, paranoia, confusion, dysphoria, seizures with fever, tremor, palpitations, hypo-/hypertension, rashes, aggression, difficulty breathing, leg and abd pain. Toxic dose above 20 mg.
Study Clozaril (Clozapine) adverse effects
- Antipsychotic; Interferes with dopamine receptor binding with lack of EPS. Acts as adrenergic, cholinergic, histaminergic, sertonergic antagonist
- used for management of schizophrenic pts for whom other antipsychs have failed; recurrent suicidal behavior
- Black Box Warning: Severe CNS depression, hypotension, myocarditis
- Can be taken w/ or w/o food. Confirm PO med swallowed and monitor for hoarding of med
- Side effects: Neuroleptic maglignant syndrome, seizures, leukopenia, agranulocytosis, eosinophilia, death w/ dementia pts EPS
Study symptoms of Tardive Dyskinesia
Involves irregular, repetitive involuntary movements of mouth, face, tounge. Begin no earlier than 6 months after med began or when med is reduced/withdrawn. May be irreversible Prevention includes using lowest dose of typical antipsychs and usage of atypical antipsychs. Risk factors include: age over 50, female, affective disorder (depression), brain damage/dysfunction, increased duration of treatment, standard antipsych med
Review the medication Lithium
Gold standard in bipolar pharmacologic treatment; indicated for manic symptoms (rapid speech, flight of ideas, irritability, grandiose thinking, impulsiveness, and agitation). Also used as augmentation in pts with major depression that only partially respond to antidepressants. Actively transported across cell membranes and alters Na transport in nerve and muscle cells. Leads to increased storage of catecholapines, reduced dopamine, increased norepipinephrine, increased GABA activity, and increased serotonin sensitivity. Assess: mental status, sodium intake (decreased intake with decreased fluids can lead to lithium retention; increased sodium, fluids may decrease lithium retention)
Study Tricyclic Antidepressants and Serotonin Syndrome
- Just as effective as other antidepressants but more serious side effects and higher lethal potential.
- Act on variety of neurotransmitter (norepinephrine and sereotonin reuptake system)
- Common side effects: sedation, orthostatic hypotension, anticholinergic side effects.
- Other side effects: tremors, restlessness, insomnia, n/v, confusion, edema, headache, seizures, blood dyscrias, fever, sore throat, malaise and rash.
- May produce symptoms of NMS and mild forms of EPS
Study herbal supplements and depression
Regulated like foods, not meds and exempt from FDA efficacy and safety standards. Often have adverse reactions and interact with Rx meds. St. John’s Wort (SJW) used for depression, pain, anxiety, insomnia, and PMS. Believed to modulate serotonin, dopamine and norepinephrine. Risk for developing serotonin syndrome increases with other serotonergic drugs. Should not be taken with antidepressants.
15) Study indication of use for Antipsychotics
Indicated for schizophrenia, mania and autism and to treat symptoms of psychosis (hallucinations, delusions, disorganized thinking, agitation, bizarre behavior)
Review what Oculogyric crisis
Muscles that control eye movement tense and pull eyeball so pt is looking at ceiling.
Review Clozaril (Clozapine) and monitoring of side effects
- Assess: I&O, hypotension, EPS (akathisia, tardive dyskinesia, pseudoparkinsonism) NMS, constipation.
- Interactions: weak inhibitors include antidepressants (fluvoxamine,j nefazodone, and norfluoxetine) Potent inhibitors include ketoconazole, protease inhibitors, erythromycin. If used with carbamazepine, dose should be increased. Antidepressants (fluoxetine and paroxetine) can increase level of antipsych
Review Disordered Water Balance
May go undetected for months or years. Ingesting large amounts of water over prolonged period leads to ccomplications such as: renal dysfunction, incontinence, cardiac failure, malnutrition, permanent brain damage. Can progress to water intoxication when kidney’s capacity is overwhelmed and serum sodium falls below 120 (Symptoms of muscle twitching, irritability; risk for seizures, coma, or death). Pts are “driven to drink” and may consume 4-10 L/ day. May drink from fountains, showers, or toilets. Frequent trips to bathroom. Responses to fluid restrictions: emotional, increased psychotic symptoms, irritability, lability. Caused by changes in sodium levels
Review Antipsychotic Drugs-first and second generation on page 353 (table
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Study Schizoaffective Disorder and Risk factors
Varying degrees of schizophrenia and mood disorders. Pts at risk for suicide. Pts with psychosis are increased risk with comorbid depression. Risk factors for suicide increase with use of alcohol/substances, cigarette smoking, previous suicide attempt, and hospitalization. Lack of regular contact may be long term risk.
Review Borderline Personality Disorder and wrist cutting
Pts with BPD are impulsive and may respond to stress by harming self. Self-harm is effort to self-soothe by activating endogenous endorphins. Linehan suggests Five Senses Exercise:
- Vision- go outside and look at star or flowers or leaves
- Hearing- listening to invigorating music or sounds of nature
- Smell- light a scented candle, boil a cinnamon stick in water
- Taste- drink soothing, warm, nonalcoholic beverage
- Touch- take a hot bubble bath, pet dog or cat, get a massage
Study Paranoid Personality Traits
Traits are longstanding suspiciousness and mistrust of persons in general. Refuse to assume personal responsibility for feelings, assign responsibility to others, and avoid relationships in which they are not in control or lose power. Pts are suspicious, guarded and hostile. Actions of others misinterpreted as deception, depreciation, and betrayal. Often unforgiving and hold grudges. Distance self from others. Persistent ideas of self-importance and tendency to be rigid and controlled
Know the most common indicator for ECT:
Most effective treatment for sever depression, also used for mania, schizophrenia (when other treatments failed).
Know common aftereffects of ECT
Headache, nausea, muscle pain. Memory oss is long-term effect