Final Exam Flashcards
Diabetes Insidious is caused by?
Antidiuretic hormone (ADH) hyposecretion
Negative Feedback inhibition occurs when?
Thyroid hormone (TH) targets the anterior pituitary
The hypothalamus-hypophyseal portal system connects the hypothalamus to the?
Anterior Pituitary (adenohypophysis)
What has both endocrine and Exocrine functions?
The gonads (ovaries and testes) (and the pancreas)
Many hours after a meal , what happens in the pancreas?
Alpha (a) cells in the pancreatic islets secrete glucagon, which raises blood glucose
What hormone does not stimulate the release of another hormone by its target cells?
PRL = Prolactin (secreted by pituitary gland, targets breasts/milk)
What does antidiuretic hormone (ADH) target?
the kidneys
Is Insulin a steroid hormone?
No
Is luteinizing hormone (LH) a hypothalamic hormone?
NO
What is up-regulation?
the increase in the number of receptors making a target cell more sensitive to a hormone
What gland responds to Hypocalcemia?
The Parathyroid gland secretes PTH to raise blood calcium levels
What does the posterior pituitary secrete?
Oxytocin (OT)
What does the absence of iodine in the diet lead to?
Hypothyroidism
What does Parathyroid Hormone (PTH) do?
Promotes the resorption of calcium from bone
What does the thyroid gland do?
secretes a hormone that increases the body’s metabolic rate, promotes alertness, quickens reflexes, and stimulates the fetal nervous system
What is the hormone that stimulates the anterior pituitary to secrete ACTH (adrenocorticotropic hormone)?
Corticotropin releasing hormone (CRH)
Are Type 1 and Type 2 Diabetes Mellitus (DM) characterized by lack of or low levels of insulin?
NO
What does the anterior pituitary secrete?
Growth Hormone aka somatotropin
What hormone has more target cells in the body than any other?
Growth Hormone
ACTH (adrenocorticotropic hormone) stimulates the secretion of what horomone?
Glucocorticoid (cholesterol-derived steroid hormones synthesised and secreted by the adrenal gland)
What does Growth Hormone hypersecretion cause in childhood and adulthood?
In childhood causes gigantism , in adulthood causes acromegaly
What is acromegaly?
The thickening of bones and soft tissues, especially in the hands, face, and feet due to GH hyper-secretion
If a cell has a1 adrenergic receptors, what is it sensitive to?
Norepinephrine (NE)
What is the background rate of sympathetic and parasympathetic activity called?
Autonomic tone
Preganglionic fibers run from ____ to ____
gray matter to autonomic ganglion
What do muscarinic receptors bind and where are they found?
They bind acetylcholine and are found on all cardiac and smooth muscle, and glands when they have cholinergic innervation
Do splanchnic nerves synapse at the sympathetic ganglion?
No, they pass through the sympathetic ganglion without synapsing
Where does the parasympathetic division originate?
The brain and sacral regions
Where does the sympathetic division originate?
The thoracic and lumbar regions
Are sympathetic fibers associated with digestion?
NO
Does the sympathetic division have short or long preganglionic fibers?
SHORT
Does the parasympathetic division have short or long preganglionic fibers?
LONG
What does the adrenal medulla mostly secrete?
Epinephrine (adrenaline)
Where is the sympathetic chain ganglion found?
At all levels of the spine
Is the adrenal medulla under dual control of the ANS?
NO it is not
What is associated with the fight or flight response?
Inhibition of digestion and reduced urinary output (sympathetic division)
What happens when ACh binds to a nicotinic receptor of a muscle cell?
ACh binding to a nicotinic receptor is ALWAYS excitatory
The 2 ACh receptors
Nicotinic and muscarinic receptors
What is secreted by nearly all sympathetic post ganglionic fibers?
Norepinephrine (NE)
2 Types of NE receptors
a-adrenergic and b-adrenergic receptors
a-adrenergic receptors
excitatory
b-adrenergic receptors
inhibitory
Most preganglionic fibers in the sympathetic nervous system synapse with how many postganglionic neurons?
10-20
How does the effect of autonomic fibers on target cells differ from somatic fibers?
Autonomic fibers can be excitatory or inhibitory. Somatic fibers are always excitatory
Properties of the preganglionic fibers of the autonomic efferent pathway
myelinated and release ACh
What is the neurotransmitter associated with autonomic ganglia?
ACh. It is always ACh for the junction between preganglionic fiber and autonomic ganglion.
What are the neurotransmitters associated with post ganglionic nerve fibers?
ACh if its parasympathetic and ACh if its cholinergic sympathetic or NE if its adrenergic sympathetic
Properties of autonomic nerve fibers pre and post ganglion
Preganglionic fiber is myelinated , post ganglionic fiber is unmyelinated
White Rami
= INCOMING SIGNAL
Grey Rami
= OUTGOING SIGNAL
What do the white and gray rami carry?
White rami carries preganglionic myelinated neurons, Grey rami carries post ganglionic unmyelinated neurons
What does the Autonomic nervous system control?
The Glands, smooth muscle, and caridac muscle. It does NOT control skeletal muscle
Where are most fibers of the parasymathetic division found?
In the Vagus
Motor pathways of the autonomic nervous system usually involve how many neurons?
2
Where do preganglionic sympathetic fibers release neurotransmitters?
Into paravertebral ganglion (sympathetic chain ganglion)
What does the incus articulate with?
The malleus and stapes
Where do nerve fibers from all regions of the retina converge?
onto the optic disc and exit the eye by way of the optic nerve
What produces a receptor potential in a taste bud?
The gustatory cells
What detects changes in CSF pH?
Chemoreceptors
What produces that taste sensation Umami?
Amino acids such as aspartic acid and glutamine
What houses the sprial organ?
the Cochlea