Final - autoimmunity Flashcards
genes associated with autoimmunity
- NOD2
- PTPN22
- Cytokine receptors
adjuvant effect
- APCs
- up regulation of co stimulators breaks tolerance
what is IPEX and what goes wrong
- rare x linked disease
- defect in FOXP3
PTPN22 strongly associated with
rheumatoid arthritis
immunologic factors associated with rheumatoid arthritis
- RF (rheumatoid factor)
- anti-CCP
- mediators such as TNFa
name 4 x-linked autoimmune diseases
- x-linked agammaglobulinemia (Bruton’s)
- hyper IgM syndrome
- SCIDS
- Wiscott-Aldrich syndrome
name one dominant and two recessive autosomal immunodeficiency diseases
D: C1 inhibitor deficiency (hereditary angiodema)
R: DiGeorge, SCID (x-linked)
main idea behind Bruton’s disease (x-linked) and main characteristic
- B cells can’t mature
- pattern of repeated infections
DiGeorge main idea and characteristics
- 22q11 deletion
- 3rd and 4th pharyngeal pouches
- loss of T-cell mediated immunity
- candida (thrush)
two types of SCID
- cytokine receptor - x-linked
- ADA - autosomal recessive
C1 inhibitor deficiency (hereditary angiodema) main idea and characteristics
- C1, Hagemann factor, degranulation of mast cells
- autosomal dominant
importance of gag component of HIV genome
- makes precursor polyprotein which gets processed into important proteins for the capsid, nucleocapsid, and matrix
- p17, 24, 7, 6
explain importance of pol component of HIV genome
makes:
- p10 - HIV protein for major processing
- p66/51 - reverse transcriptase
- p32 - integrases
explain importance of env component of HIV genome
- protein for envelope
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which HIV genome components are targets of anti-HIV protease inhibitor drugs?
pol and gag, because they both create precursor proteins that are processed by viral protease, the drugs target this protease
